R. T. Lorenz
Works (2)
Updated: July 5th, 2023 15:53
1991 journal article
PHYSIOLOGICAL-EFFECTS OF FENPROPIMORPH ON WILD-TYPE SACCHAROMYCES-CEREVISIAE AND FENPROPIMORPH-RESISTANT MUTANTS
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 35(8), 1532–1537.
MeSH headings : Cell Division / drug effects; Drug Resistance, Microbial / genetics; Fungicides, Industrial / pharmacology; Morpholines / pharmacology; Mutation / genetics; Mutation / physiology; Saccharomyces cerevisiae / drug effects; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Sterols / metabolism; Sterols / pharmacology
TL;DR:
The resistance to fenpropimorph involves two recessive genes, each of which allows a semiresistance, when they are isolated apart from one another, and the uptake of exogenous sterol by wild-type cells was greatly enhanced in the presence of fenPropimorph and the growth inhibition could only be overcome with bulk levels ofExogenous C-5,6-unsaturated sterols.
(via Semantic Scholar)
aac.asm.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1990 journal article
EFFECTS OF LOVASTATIN (MEVINOLIN) ON STEROL LEVELS AND ON ACTIVITY OF AZOLES IN SACCHAROMYCES-CEREVISIAE
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 34(9), 1660–1665.
MeSH headings : Azoles / pharmacology; Carbon Radioisotopes; Cholesterol / pharmacokinetics; Drug Synergism; Esterification; Heme / physiology; Hydroxymethylglutaryl CoA Reductases / genetics; Isoenzymes / genetics; Lovastatin / pharmacology; Microbial Sensitivity Tests; Oxygen Consumption / drug effects; Saccharomyces cerevisiae / drug effects; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Sterols / metabolism; Sterols / pharmacokinetics
TL;DR:
The hypocholesterolemic drug Lovastatin (mevinolin) was found to be very effective in lowering the sterol levels of the wild-type yeast Saccharomyces cerevisiae and caused the MICs of three azole antifungal drugs to be lowered from 6- to 32-fold when lovastatin was present in the medium at 10 micrograms/ml.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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