Weiqing Zhou

Works (1)

Updated: July 5th, 2023 16:01

2000 journal article

Evaluation of the binding between potential anti-HIV DNA-based drugs and viral envelope glycoprotein gp120 by capillary electrophoresis with laser-induced fluorescence detection

ANALYTICAL BIOCHEMISTRY, 284(2), 334–341.

By: W. Zhou n, K. Tomer* & M. Khaledi n

author keywords: phosphorothioate oligodeoxynucleotide; HIV envelope glycoprotein gp120; affinity-capillary electrophoresis; laser-induced fluorescence detection
MeSH headings : Anti-HIV Agents / metabolism; Base Sequence; Binding, Competitive; DNA Primers; Electrophoresis, Capillary / methods; Evaluation Studies as Topic; HIV Envelope Protein gp120 / metabolism; HIV-1 / metabolism; Lasers; Protein Binding; Spectrometry, Fluorescence
TL;DR: Capillary electrophoresis with laser-induced fluorescence detection (CE-LIF) was used to systematically evaluate binding between Sd and HIV-1 gp120 and showed that the interaction had a strong dependence on the sulfur phosphorothioate backbone. (via Semantic Scholar)
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