C. A. Novotney

Works (3)

Updated: July 5th, 2023 15:52

1994 journal article

EFFECT OF WHOLE-BODY HYPERTHERMIA ON CARBOPLATIN DISPOSITION AND TOXICITY IN DOGS

INTERNATIONAL JOURNAL OF HYPERTHERMIA, 10(6), 807–816.

By: R. Page n, M. Mcentee n, P. Williams  n, S. George *, G. Price n, C. Novotney n, M. Hauck n, J. Riviere n, M. Dewhirst*, D. Thrall n

MeSH headings : Animals; Carboplatin / administration & dosage; Carboplatin / pharmacokinetics; Carboplatin / toxicity; Combined Modality Therapy; Dog Diseases / drug therapy; Dog Diseases / metabolism; Dog Diseases / therapy; Dogs; Dose-Response Relationship, Drug; Female; Hematopoietic System / drug effects; Hyperthermia, Induced / methods; Hyperthermia, Induced / veterinary; Male; Neoplasms / drug therapy; Neoplasms / therapy; Neoplasms / veterinary
TL;DR: A randomized phase II evaluation should be initiated to determine if a therapeutic gain can be achieved using combined CBDCA and WBH and further refinement of the CBDCA dose in such a trial should be based on both pharmacokinetic parameters and normal tissue response. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1992 journal article

PHASE-I EVALUATION OF DOXORUBICIN AND WHOLE-BODY HYPERTHERMIA IN DOGS WITH LYMPHOMA

JOURNAL OF VETERINARY INTERNAL MEDICINE, 6(4), 245–249.

By: C. Novotney*, R. Page n, D. Macy n, M. Dewhirst *, G. Ogilvie n, S. Withrow n, M. Mcentee, G. Heidner ...

MeSH headings : Animals; Bone Marrow / drug effects; Chemotherapy, Adjuvant; Dog Diseases / therapy; Dogs; Doxorubicin / adverse effects; Doxorubicin / therapeutic use; Drug Evaluation; Female; Heart / drug effects; Hyperthermia, Induced / veterinary; Lymphoma / therapy; Lymphoma / veterinary; Male; Treatment Outcome
TL;DR: Fifteen previously untreated dogs with histologically confirmed, high-grade multicentric lymphoma were entered into a phase I study to evaluate combined doxorubicin and whole-body hyperthermia (DOX/WBH), and two dogs had treatment-related toxicity. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1990 journal article

LYMPHOCYTE POPULATION-CHANGES IN CATS NATURALLY INFECTED WITH FELINE IMMUNODEFICIENCY VIRUS

AIDS, 4(12), 1213–1218.

By: C. Novotney n, R. English, J. Housman, M. Davidson, M. Nasisse, C. Jeng, W. Davis, M. Tompkins

author keywords: FELINE IMMUNODEFICIENCY VIRUS; CD4-CD8 RATIOS; AIDS; LENTIVIRUS
MeSH headings : Animals; Antibodies, Monoclonal; Antibodies, Viral / blood; B-Lymphocytes / immunology; Blotting, Western; CD4-Positive T-Lymphocytes / immunology; Cats; Feline Acquired Immunodeficiency Syndrome / immunology; Female; Flow Cytometry; Immunodeficiency Virus, Feline / immunology; Leukocyte Count; Male; T-Lymphocyte Subsets / immunology; T-Lymphocytes, Regulatory / immunology
TL;DR: Findings are similar to those in HIV infections and indicate that, like HIV, FIV causes a selective reduction in CD4+ cells and should be an excellent model for studying retrovirus-induced AIDS. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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