@article{papich_van camp_cole_whitacre_2002, title={Pharmacokinetics and endometrial tissue concentrations of enrofloxacin and the metabolite ciprofloxacin after i.v. administration of enrofloxacin to mares}, volume={25}, ISSN={["1365-2885"]}, DOI={10.1046/j.1365-2885.2002.00434.x}, abstractNote={Enrofloxacin was administered i.v. to five adult mares at a dose of 5 mg/kg. After administration, blood and endometrial biopsy samples were collected at regular intervals for 24 h. The plasma and tissue samples were analyzed for enrofloxacin and the metabolite ciprofloxacin by high‐pressure liquid chromatography. In plasma, enrofloxacin had a terminal half‐life (t½), volume of distribution (area method), and systemic clearance of 6.7 ± 2.9 h, 1.9 ± 0.4 L/kg, and 3.7 ± 1.4 mL/kg/min, respectively. Ciprofloxacin had a maximum plasma concentration (Cmax) of 0.28 ± 0.09 μg/mL. In endometrial tissue, the enrofloxacin Cmax was 1.7 ± 0.5 μg/g, and the t½ was 7.8 ± 3.7 h. Ciprofloxacin Cmax in tissues was 0.15 ± 0.04 μg/g and the t½ was 5.2 ± 2.0 h. The tissue:plasma enrofloxacin concentration ratios (w/w:w/v) were 0.175 ± 0.08 and 0.47 ± 0.06 for Cmax and AUC, respectively. For ciprofloxacin, these values were 0.55 ± 0.13 and 0.58 ± 0.31, respectively. We concluded that plasma concentrations achieved after 5 mg/kg i.v. are high enough to meet surrogate markers for antibacterial activity (Cmax:MIC ratio, and AUC:MIC ratio) considered effective for most susceptible gram‐negative bacteria. Endometrial tissue concentrations taken from the mares after dosing showed that enrofloxacin and ciprofloxacin both penetrate this tissue adequately after systemic administration and would attain concentrations high enough in the tissue fluids to treat infections of the endometrium caused by susceptible bacteria.}, number={5}, journal={JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS}, author={Papich, MG and Van Camp, SD and Cole, JA and Whitacre, MD}, year={2002}, month={Oct}, pages={343–350} }
 @article{kishnani_faulkner_vancamp_jackson_brown_boney_koeberl_chen_2001, title={Canine model and genomic structural organization of glycogen storage disease type Ia (GSD Ia)}, volume={38}, ISSN={["0300-9858"]}, DOI={10.1354/vp.38-1-83}, abstractNote={ A canine model of glycogen storage disease Ia (GSD Ia), similar clinically, biochemically, and pathologically to the human disease, was established by crossbreeding Maltese and Beagle dogs carrying a mutated, defective glucose-6-phosphatase (G-6-Pase) gene. Ten puppies were born in three litters from these crossbreedings. Six were homozygous for the previously described M121I GSD Ia mutation. Of these six affecteds, two were stillborn, and one died at 2, 32, and 60 days of life, respectively (puppies A, B, C, D, E), while one is alive at age 15 months (puppy F). Affected puppies exhibited tremors, weakness, and neurologic signs when hypoglycemic. They had postnatal growth retardation and progressive hepatomegaly. Biochemical abnormalities included fasting hypoglycemia, hyperlactacidemia, hypercholesterolemia, hypertriglyceridemia, and hyperuricemia. Microscopic examination of tissues from affected puppies showed diffuse, marked hepatocellular vacuolation, with distended clear hepatocytes and central to marginally located rounded nuclei. In the kidneys of puppies D and E, there was segmental glomerular sclerosis and vacuolation of proximal convoluted tubular epithelium. Biochemical analysis revealed increased liver glycogen content and isolated markedly reduced G-6-Pase enzyme activity in liver and kidney. The canine G-6-Pase gene was characterized by screening a canine genomic library. It spans ~ 11.8 kb and consists of five exons with >90% amino acid sequence homology to the derived human sequence. The first 1.5 kb of the 5′ region was sequenced and contains several putative response element motifs homologous to the human 5′ region. Establishment of this canine colony of GSD Ia that closely resembles human disease and isolation of the canine genomic gene provides an excellent model for studying pathophysiology and long-term complications and an opportunity to develop novel therapeutic approaches such as drug and gene therapy. }, number={1}, journal={VETERINARY PATHOLOGY}, author={Kishnani, PS and Faulkner, E and VanCamp, S and Jackson, M and Brown, T and Boney, A and Koeberl, D and Chen, YT}, year={2001}, month={Jan}, pages={83–91} }
 @article{cavalieri_farin_kinder_van camp_whitacre_washburn_britt_2001, title={Ovarian follicular development following administration of progesterone or aspiration of ovarian follicles in Holstein cows}, volume={55}, ISSN={["1879-3231"]}, DOI={10.1016/S0093-691X(01)00445-9}, abstractNote={The objective of this study was to compare the effects of administration of a single injection of progesterone (P4) and follicle aspiration on Day 7 of the estrous cycle on the timing and synchrony of follicular wave emergence, time of ovulation, and concentrations of P4, estradiol and FSH in Holstein cows. Twenty cows were assigned to 4 groups (n=5 cows per group) in a 2 by 2 factorial arrangement. Cows were treated on Day 7 (Day 0 = estrus) of the estrous cycle with either sham follicular aspiration and an oil vehicle administered intramuscularly (control), aspiration of ovarian follicles (aspiration), 200 mg of P4 im, or aspiration and 200 mg of P4 im (aspiration + P4). On Day 11, PGF(2alpha)(25mg) was administered to all groups. Synchrony of ovulation was less variable in each of the treatment groups compared with the control group (P<0.05), whereas ovulation was delayed in cows in the P4 group (P<0.05). Day of follicular wave emergence was delayed in the cows of the P4 group compared with cows in the aspiration and aspiration + P4 groups (P<0.01), whereas variability in wave emergence was less among both groups of aspirated cows compared with the cows in the control group (P<0.01). More follicles 4 to 7 mm in diameter were detected in the 2 aspiration groups compared with the cows in the control and P4 group (P<0.05). No difference was detected among groups in the maximum concentration of FSH associated with follicular wave emergence. We conclude that both the administration of P4 and the aspiration of follicles on Day 7 of the estrous cycle improves the synchrony of ovulation when luteolysis is induced on Day 11 and results in similar concentrations of FSH at the time of follicular wave emergence, but the timing of wave emergence and the number of follicles post-emergence differ.}, number={3}, journal={THERIOGENOLOGY}, author={Cavalieri, J and Farin, PW and Kinder, JE and Van Camp, SD and Whitacre, MD and Washburn, SP and Britt, JH}, year={2001}, month={Feb}, pages={805–821} }
 @article{van camp_papich_whitacre_2000, title={Administration of ticarcillin in combination with clavulanic acid intravenously and intrauterinely to clinically normal oestrous mares}, volume={23}, ISSN={["1365-2885"]}, DOI={10.1046/j.1365-2885.2000.00297.x}, abstractNote={Ticarcillin and clavulanic acid (potassium clavulanate) were administered to normal oestrous mares intravenously (i.v.) at a dose of 50 and 1.67 mg/kg for ticarcillin and clavulanate, respectively. In a crossover design, the same drugs were administered intrauterine (i.u.) at a dose of 12.4 and 0.4 mg/kg for ticarcillin and clavulanate, respectively. The i.u. dose was administered in 100 mL of saline solution. Endometrial tissue biopsies and plasma samples were collected after drug administration for the determination of ticarcillin and clavulanate concentrations by high-pressure liquid chromatography and pharmacokinetic calculations. After i.u. administration both drugs were poorly absorbed into the plasma. The ticarcillin half-life from tissue and plasma was short after i.v. administration. Although concentrations in tissue were higher after i.u. administration than i.v., concentrations of ticarcillin declined rapidly, which would necessitate frequent treatment in order to maintain drug concentrations above the minimum inhibitory concentrations (MIC) throughout the treatment period. Clavulanate concentrations in tissue were either low or persisted for only a short time after administration via either route. It appears that addition of clavulanate to the formulation for treatment of i.u. infections in mares is of questionable value based on these concentrations.}, number={6}, journal={JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS}, author={Van Camp, SD and Papich, MG and Whitacre, MD}, year={2000}, month={Dec}, pages={373–378} }
 @article{vaden_sellon_melgarejo_williams_trogdon_vancamp_argenzio_2000, title={Evaluation of intestinal permeability and gluten sensitivity in Soft-Coated Wheaten Terriers with familial protein-losing enteropathy, protein-losing nephropathy, or both}, volume={61}, ISSN={["0002-9645"]}, DOI={10.2460/ajvr.2000.61.518}, abstractNote={Abstract}, number={5}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Vaden, SL and Sellon, RK and Melgarejo, LT and Williams, DA and Trogdon, MM and VanCamp, SD and Argenzio, RA}, year={2000}, month={May}, pages={518–524} }
 @article{vancamp_1997, title={Bull infertility: preface}, volume={13}, number={2}, journal={Veterinary Clinics of North America. Food Animal Practice}, author={Vancamp, S. D.}, year={1997}, pages={195} }
 @article{van camp_estill_1990, title={Manipulating the canine estrous cycle}, volume={2}, number={1}, journal={Veterinary Medicine Report}, author={Van Camp, S. D. and Estill, C. T.}, year={1990}, pages={4} }
 @misc{vancamp_1988, title={ENDOMETRIAL BIOPSY OF THE MARE - A REVIEW AND UPDATE}, volume={4}, ISSN={["0749-0739"]}, DOI={10.1016/S0749-0739(17)30639-9}, abstractNote={The endometrial biopsy is a safe and effective means of predicting a mare's prognosis for foaling. A thorough understanding of the normal cyclic and seasonal pattern displayed by the normal endometrium is necessary before interpreting pathologic changes. Several systems for prognostic classification have been proposed, including a recent one that combines many of the criteria used in the other systems.}, number={2}, journal={VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE}, author={VANCAMP, SD}, year={1988}, month={Aug}, pages={229–245} }