@article{saxton_eisen_1984, title={Genetic analysis of brown adipose tissue, obesity and growth in mice}, volume={106}, number={4}, journal={Genetics}, author={Saxton, A. M. and Eisen, E. J.}, year={1984}, pages={705} } @article{saxton_eisen_leatherwood_1984, title={RELATIONSHIP OF BROWN ADIPOSE-TISSUE WITH GROWTH AND OBESITY DIFFERENCES IN GENETICALLY SELECTED MOUSE LINES}, volume={26}, ISSN={["0008-4093"]}, DOI={10.1139/g84-053}, abstractNote={A recent hypothesis considers brown adipose tissue (BAT) to be an important source of diet-induced thermogenesis (DIT). In turn, DIT and thermogenesis in general are believed to be key factors in the control of obesity of laboratory rodents. This hypothesis was developed from the study of single gene mutant obese rodents. The present research tested this hypothesis in mice with polygenic control of growth and obesity, which is more characteristic of the type of genetic variation expected in human and other mammalian populations. Control and high fat diets were used to test responses of five genetically selected lines of mice showing different patterns of growth and obesity. All lines deposited more fat on the high fat diet, but the most obese line showed the largest increase in BAT and the lipid-free dry (LFD) component of BAT. Use of LFD per unit body weight gave results which supported the hypothesis being tested, but it was argued that this measure is misleading. When brown and white adipose tissue growth relative to body weight were examined, 2 of the 10 line-diet groups showed alterations in BAT growth patterns. However, it was concluded that BAT, if involved at all, was not a major factor in growth and obesity differences.}, number={3}, journal={CANADIAN JOURNAL OF GENETICS AND CYTOLOGY}, author={SAXTON, AM and EISEN, EJ and LEATHERWOOD, JM}, year={1984}, pages={339–347} } @article{saxton_1983, title={A COMPARISON OF EXACT AND SEQUENTIAL-METHODS IN MULTISTAGE INDEX SELECTION}, volume={66}, ISSN={["0040-5752"]}, DOI={10.1007/bf00281843}, number={1}, journal={THEORETICAL AND APPLIED GENETICS}, author={SAXTON, AM}, year={1983}, pages={23–28} } @article{saxton_1982, title={A NOTE ON A COMPUTER-PROGRAM FOR INDEPENDENT CULLING}, volume={35}, ISSN={["0003-3561"]}, DOI={10.1017/S0003356100027513}, abstractNote={ABSTRACT Calculating optimal truncation values for independent culling selection procedures has been difficult. Previously published charts took much of the tedium out of the calculations but the charts are difficult to read with accuracy and are not available for all possible parameter values. Therefore a computer program was written to calculate optimal truncation values for two-trait independent culling, with the option of restricting the genetic change of one or both traits. The program is described and an example of its use is given.}, number={OCT}, journal={ANIMAL PRODUCTION}, author={SAXTON, AM}, year={1982}, pages={295–297} }