@article{sellers_guthrie_1972, title={DISTRIBUTION AND METABOLISM OF C-14-DIELDRIN IN RESISTANT AND SUSCEPTIBLE HOUSE-FLY DIPTERA-MUSCIDAE}, volume={65}, ISSN={["0022-0493"]}, DOI={10.1093/jee/65.2.378}, abstractNote={Studies on penetration of 14C-dieldrin into Musca domestica L. revealed that shortly after treatment, amounts of radioactivity recovered from head and thoracic cuticle were 2-fold higher in flies resistant (R) to dieldrin than in those susceptible (S). However, after 24 hr, recoveries were similar for both strains. Assays of radioactivity in the gut (including reproductive organs) and flight muscle showed consistently lower recoveries from R flies during the 1st 3-5 hours after treatment.

In the metabolism study, 85% of the absorbed radioactivity was recovered as the parent compound from the R strain during the 1st 24 hours following treatment. The 48-hour R fly homogenate fraction represented approximately 2% of the applied dose and contained metabolites chromatographically similar 10 those in the feces fraction.

Fly feces fractions from Rand S flies contained 5.7 and 1.2%, respectively, of the applied dose at 24 hours post-treatment. Of these quantities, 2.9 and 0.4% were metabolites. After the maximum holding period of 120 hours, 12% of the applied radioactivity was recovered in R flies, 2.4% as the parent dieldrin, and the remainder as more polar metabolites.

The major water-soluble metabolite, representing about 9% of total radioactivity recovered from R fly feces 5 days after treatment, appeared to be conjugated with an unidentified macromolecule of low molecular weigh. Two minor organ soluble metalloids characterized in 5 chromatographic systems and by IR and mass spectroscopy could not be identified positively.

Although R flies showed decreased rates of penetration and increased amounts of metabolites at extended periods after treatment, the quantitative differences between R and S strains do not explain adequately the resistance mechanism.}, number={2}, journal={JOURNAL OF ECONOMIC ENTOMOLOGY}, author={SELLERS, LG and GUTHRIE, FE}, year={1972}, pages={378-&} }
 @article{sellers_1971, title={Distribution, metabolism, and localization of dieldrin in the adult house fly, Musca domestica (L.)}, volume={32}, number={2}, journal={Dissertation Abstracts International. B, Sciences and Engineering}, author={Sellers, L. G.}, year={1971} }