Works (21)
Updated: July 5th, 2023 16:04
2004 patent
Anti-cryptosporidium parvum preparations
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2004 patent
Neutralization-sensitive epitopes of Cryptosporidium parvum
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2002 journal article
Efficacy of monoclonal antibodies against defined antigens for passive immunotherapy of chronic gastrointestinal cryptosporidiosis
ANTIMICROBIAL AGENTS AND CHEMOTHERAPY, 46(2), 275–282.
MeSH headings : Animals; Antibodies, Monoclonal / therapeutic use; Bioreactors; Body Weight / drug effects; Chronic Disease; Cryptosporidiosis / drug therapy; Cryptosporidiosis / parasitology; Cryptosporidium parvum / drug effects; Disease Models, Animal; Feces / parasitology; Female; Gastrointestinal Diseases / drug therapy; Gastrointestinal Diseases / parasitology; Immunization, Passive; Mice; Mice, SCID; Oocytes; Treatment Outcome
TL;DR:
The results indicate that anti-CSL MAb 3E2 has highly significant efficacy in reducing, but not eliminating, persistent C. parvum infection.
(via Semantic Scholar)
aac.asm.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2001 patent
Neutralization-sensitive epitopes of Cryptosporidium parvum
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2001 journal article
Targeted disruption of CSL ligand-host cell receptor interaction in treatment of Cryptosporidium parvum infection
Journal of Eukaryotic Microbiology, (2001), 44S–46.
Source: NC State University Libraries
Added: August 6, 2018
2000 patent
Anti-Cryptosporidium parvum preparations
Washington, DC: U.S. Patent and Trademark Office.
Source: NC State University Libraries
Added: August 6, 2018
2000 chapter
Detection of mucosally delivered antibody to Cryptosporidium parvum p23 in infected calves
In K. M. K. J. A. House & E. P. J. Gibbs (Eds.), Tropical veterinary diseases: Control and prevention in the context of the new world order (Vol. 916, pp. 378–387). New York, NY: New York Academy of Sciences.
Ed(s): K. J. A. House & E. Gibbs
Source: NC State University Libraries
Added: August 6, 2018
2000 journal article
Excretion patterns of mucosally delivered antibodies to p23 in Cryptosporidium parvum infected calves
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 76(3-4), 309–317.
author keywords: cryptosporidiosis; mucosal antibodies; excretion patterns; calves; anti-p23
MeSH headings : Animals; Animals, Newborn; Antibodies, Protozoan / immunology; Antibodies, Protozoan / physiology; Cattle; Cattle Diseases / immunology; Cattle Diseases / parasitology; Cryptosporidiosis / immunology; Cryptosporidiosis / parasitology; Cryptosporidiosis / veterinary; Cryptosporidium parvum / growth & development; Cryptosporidium parvum / immunology; Feces / parasitology; Flow Cytometry / veterinary; Immunity, Mucosal / physiology; Immunoassay / veterinary; Immunoglobulin Isotypes / immunology; Immunoglobulin Isotypes / physiology; Male; Microspheres; Specific Pathogen-Free Organisms
TL;DR:
Fecal samples obtained at intervals from six calves with acute cryptosporidiosis contained antibodies of multiple isotypes to p23, and one calf that died following exposure to Cryptosporidium parvum oocysts lacked detectable anti-p23 antibodies.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Primary immunodeficiencies of horses
VETERINARY CLINICS OF NORTH AMERICA-EQUINE PRACTICE, 16(1), 105-+.
MeSH headings : Agammaglobulinemia / veterinary; Animals; Horse Diseases / immunology; Horses; Immunoglobulin M / deficiency; Immunologic Deficiency Syndromes / veterinary; Severe Combined Immunodeficiency / immunology; Severe Combined Immunodeficiency / veterinary
TL;DR:
The central theme is to encourage clinicians to ask, "I wonder if this horse has an underlying primary immunodeficiency disorder?" when caring for horses suffering from chronic and recurring infections and responding poorly to standard therapy.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Cryptosporidium parvum sporozoite pellicle antigen recognized by a neutralizing monoclonal antibody is a beta-mannosylated glycolipid
Infection and Immunity, 67(3), 1317–1322.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Detection of equine antibodies to Babesia Caballi by recombinant B-Caballi Rhoptry-associated protein 1 in a competitive-Inhibition enzyme-linked immunosorbent assay
Journal of Clinical Microbiology, 37(7), 2285–2290.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Protection of calves against cryptosporidiosis with immune bovine colostrum induced by a Cryptosporidium parvum recombinant protein
VACCINE, 17(17), 2142–2149.
author keywords: cryptosporidiosis; Cryptosporidium parvum; recombinant protein; colostrum; protection
MeSH headings : Animals; Antibodies, Protozoan / blood; Antigens, Protozoan / immunology; Cattle; Cattle Diseases / parasitology; Cattle Diseases / prevention & control; Colostrum / immunology; Cryptosporidiosis / parasitology; Cryptosporidiosis / prevention & control; Cryptosporidiosis / veterinary; Cryptosporidium parvum / genetics; Cryptosporidium parvum / immunology; Feces / parasitology; Female; Male; Pregnancy; Protozoan Vaccines / genetics; Protozoan Vaccines / immunology; Vaccines, Synthetic / immunology
TL;DR:
The absence of diarrhea and 2.8%) reduction in oocyst excretion indicates that immune bovine colostrum induced by immunization with C. parvum recombinant protein rC7 provided substantial protection against cryptosporidiosis in neonatal calves.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
CD8 dimer usage on alpha beta and gamma delta T lymphocytes from equine lymphoid tissues
IMMUNOBIOLOGY, 198(4), 424–438.
MeSH headings : Animals; Antibodies, Monoclonal; CD8 Antigens / immunology; CD8 Antigens / isolation & purification; Dimerization; Female; Horses; Lymphoid Tissue / immunology; Lymphoid Tissue / metabolism; Mice; Mice, Inbred BALB C; Rabbits; Receptors, Antigen, T-Cell, alpha-beta / chemistry; Receptors, Antigen, T-Cell, alpha-beta / immunology; Receptors, Antigen, T-Cell, gamma-delta / chemistry; Receptors, Antigen, T-Cell, gamma-delta / immunology; T-Lymphocyte Subsets / immunology; T-Lymphocyte Subsets / metabolism
TL;DR:
The results indicated that CD8 dimer usage by equine T lymphocytes is similar to other species and that the mAb described can be further used to separate equine CD8+ T lymphocyte subsets from the lymphoid tissues to define their function in protection against viral and other infections.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Equine SCID: mechanistic analysis and comparison with murine SCID
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 65(1), 1–9.
author keywords: equine SCID; murine SCID; analysis
MeSH headings : Animals; Blotting, Western / veterinary; DNA / chemistry; Electrophoresis, Agar Gel / veterinary; Fibroblasts / chemistry; Fibroblasts / immunology; Gene Expression Regulation; Gene Rearrangement / genetics; Gene Rearrangement / immunology; Horse Diseases / genetics; Horse Diseases / immunology; Horses; Humans; Immunoglobulin Joining Region / chemistry; Immunoglobulin Joining Region / genetics; Immunoglobulin Joining Region / immunology; Immunoglobulin Variable Region / chemistry; Immunoglobulin Variable Region / genetics; Immunoglobulin Variable Region / immunology; Mice; Mice, SCID; Polymerase Chain Reaction / veterinary; Protein Kinases / analysis; Protein Kinases / genetics; Rodent Diseases / genetics; Rodent Diseases / immunology; Severe Combined Immunodeficiency / genetics; Severe Combined Immunodeficiency / immunology; Severe Combined Immunodeficiency / veterinary
TL;DR:
Though equine SCID and murineSCID have definite phenotypic differences, both defects are likely to be the result of defective expression of the catalytic subunit of the DNA-dependent protein kinase.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
IL-4 protects adult C57BL/6 mice from prolonged Cryptosporidium parvum infection: Analysis of CD4(+)alpha beta+IFN-gamma(+) and CD4(+)alpha beta+IL-4(+) lymphocytes in gut-associated lymphoid tissue during resolution of infection
Journal of Immunology, 161(4), 1891–1900.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
A kinase-negative mutation of DNA-PK(CS) in equine scid results in defective coding and signal joint formation
Journal of Immunology, 158(8), 3565–3569.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Activation of intestinal intraepithelial T lymphocytes in calves infected with Cryptosporidium parvum
Infection and Immunity, 65(1), 185–190.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Control of equine infectious anemia virus is not dependent on ADCC mediating antibodies
VIROLOGY, 230(2), 275–280.
MeSH headings : Animals; Antibodies, Viral / immunology; Antibody-Dependent Cell Cytotoxicity / immunology; Cell Line; Cell Membrane; Equine Infectious Anemia / blood; Equine Infectious Anemia / immunology; Glycoproteins / immunology; Herpesvirus 1, Equid / immunology; Horses; Immunoglobulin G / immunology; Infectious Anemia Virus, Equine / immunology; Viral Envelope Proteins / immunology
TL;DR:
Results indicate that ADCC is not involved in the control of EIAV in carrier horses and that serum antibody from EHV-1 vaccinated horses and PBMC or PMN as effector cells caused ADCC of EHv-1-infected EK cells.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1997 journal article
Evaluation of a test for identification of Arabian horses heterozygous for the severe combined immunodeficiency trait
Journal of the American Veterinary Medical Association, 211(10), 1268-.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Genetic and biochemical analysis of erythrocyte-stage surface antigens belonging to a family of highly conserved proteins of Babesia equi and Theileria species
Molecular and Biochemical Parasitology, 90(1), 69–79.
Source: NC State University Libraries
Added: August 6, 2018
1996 journal article
A cloned gene of Cryptosporidium parvum encodes neutralization-sensitive epitopes
MOLECULAR AND BIOCHEMICAL PARASITOLOGY, 80(2), 137–147.
author keywords: Cryptosporidium parvum; epitope; genes; infectious immunity; mouse
MeSH headings : Amino Acid Sequence; Animals; Antibodies, Monoclonal; Antigens, Protozoan / genetics; Base Sequence; Cloning, Molecular; Cryptosporidiosis / immunology; Cryptosporidiosis / prevention & control; Cryptosporidium parvum / genetics; Cryptosporidium parvum / immunology; DNA, Complementary / genetics; DNA, Protozoan / genetics; Epitopes / genetics; Genes, Protozoan; Immunization; Mice; Mice, Inbred BALB C; Molecular Sequence Data; Neutralization Tests; Open Reading Frames; Peptides / genetics; Peptides / immunology; Recombinant Proteins / genetics; Recombinant Proteins / immunology
TL;DR:
The occurrence of neutralization-sensitive epitopes encoded by defined regions of the C. parvum genome suggests that recombinant proteins or synthetic peptides containing these epitopes may prove useful for inducing immune responses that diminish infection.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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