Amanda L. Wolfe

Works (1)

Updated: July 5th, 2023 15:51

2008 journal article

Synthesis and Antibiofilm Activity of a Second-Generation Reverse-Amide Oroidin Library: A Structure-Activity Relationship Study

CHEMISTRY-A EUROPEAN JOURNAL, 14(34), 10745–10761.

By: T. Ballard  n, J. Richards n, A. Wolfe n & C. Melander n

author keywords: amino acids; biological activity; drug design; medicinal chemistry; structure-activity relationships
MeSH headings : Acinetobacter baumannii / drug effects; Acinetobacter baumannii / growth & development; Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Biofilms / drug effects; Biofilms / growth & development; Drug Design; Imidazoles / chemistry; Microbial Sensitivity Tests; Molecular Structure; Pseudomonas aeruginosa / drug effects; Pseudomonas aeruginosa / growth & development; Pyrroles / chemical synthesis; Pyrroles / chemistry; Pyrroles / pharmacology; Small Molecule Libraries; Stereoisomerism; Structure-Activity Relationship
TL;DR: A second-generation library of 2-aminoimidazole-based derivatives incorporating a "reversed amide" (RA) motif in comparison to the marine natural product oroidin were synthesized and subsequently assayed for antibiofilm activity against the medically relevant Gram-negative proteobacteria P. aeruginosa and A. baumannii. (via Semantic Scholar)
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Added: August 6, 2018

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