@article{reed_lee_zhang_rashid_poe_hsieh_deighton_glassbrook_bodmer_gibson_2014, title={Systems genomics of metabolic phenotypes in wild-type Drosophila melanogaster}, volume={197}, number={2}, journal={Genetics}, author={Reed, L. K. and Lee, K. and Zhang, Z. and Rashid, L. and Poe, A. and Hsieh, B. and Deighton, N. and Glassbrook, N. and Bodmer, R. and Gibson, G.}, year={2014}, pages={781–630} }
 @article{truong_deighton_thompson_mcfeeters_dean_pecota_yencho_2009, title={Characterization of Anthocyanins and Anthocyanidins in Purple-Fleshed Sweetpotatoes by HPLC-DAD/ESI-MS/MS}, volume={58}, ISSN={0021-8561 1520-5118}, url={http://dx.doi.org/10.1021/jf902799a}, DOI={10.1021/jf902799a}, abstractNote={Purple-fleshed sweetpotatoes (PFSP) can be a healthy food choice for consumers and a potential source for natural food colorants. This study aimed to identify anthocyanins and anthocyanidins in PFSP, and to evaluate the effect of thermal processing on these polyphenolic compounds. Freeze-dried powder of raw and steamed samples of three PFSP varieties were extracted with acidified methanol using a Dionex ASE 200 accelerated solvent extractor. Seventeen anthocyanins were identified by HPLC-DAD/ESI-MS/MS for Stokes Purple and NC 415 varieties with five major compounds: cyanidin 3-caffeoylsophoroside-5-glucoside, peonidin 3-caffeoylsophoroside-5-glucoside, cyanidin 3-caffeoyl-p-hydroxybenzoylsophoroside-5-glucoside, peonidin 3-caffeoyl-p-hydroxybenzoyl-sophoroside-5-glucoside, and peonidin-caffeoyl-feruloylsophoroside-5-glucoside. Okinawa variety showed 12 pigments with 3 major peaks identified as cyanidin 3-caffeoylsophoroside-5-glucoside, cyanidin 3-(6'',6'''-dicaffeoylsophoroside)-5-glucoside and cyanidin 3-(6''-caffeoyl-6'''-feruloylsophoroside)-5-glucoside. Steam cooking had no significant effect on total anthocyanin content or the anthocyanin pigments. Cyanidin and peonidin, which were the major anthocyanidins in the acid hydrolyzed extracts, were well separated and quantified by HPLC with external standards. Cyanidin and peonidin, which contribute to the blue and red hues of PFSP, can be simply quantified by HPLC after acid hydrolysis of the anthocyanins.}, number={1}, journal={Journal of Agricultural and Food Chemistry}, publisher={American Chemical Society (ACS)}, author={Truong, Van-Den and Deighton, Nigel and Thompson, Roger T. and McFeeters, Roger F. and Dean, Lisa O. and Pecota, Kenneth V. and Yencho, G. Craig}, year={2009}, month={Dec}, pages={404–410} }
 @article{xie_flippin_deighton_funk_dickey_buchwalter_2009, title={Mercury(II) Bioaccumulation and Antioxidant Physiology in Four Aquatic Insects}, volume={43}, ISSN={["1520-5851"]}, url={http://www.scopus.com/inward/record.url?eid=2-s2.0-63149100512&partnerID=MN8TOARS}, DOI={10.1021/es802323r}, abstractNote={We examined Hg(II) bioaccumulation and compartmentalization patterns in conjunction with antioxidant responses in four aquatic insect species: two caddisflies (Chimarra sp. and Hydropsyche betteni) and two mayflies (Maccaffertium modestum and Isonychia sp). Total antioxidant capabilities differed among unexposed larvae, with both caddisfly species exhibiting elevated antioxidant activities relative to the mayflies. We were able to account for these differences by examining the constitutive activities of catalase (CAT), glutathione peroxidase (GPx), glutathione S-transferase (GST), and superoxide dismutase (SOD), in the four species. We also examined levels of reduced and oxidized glutathione and cysteine in the insects. Glutathione peroxidase and SOD were the most responsive to Hg exposure, with GPx catalytic activity increasing between 50 and 310%. Superoxide dismutase activity decreased between 35 and 50%. This SOD suppression was shown to be dose-dependent in both caddisflies, butthe strength of this suppression did not appear to be related to rates of uptake. Surprisingly, little Hg (<10%) was found in the heat-stable cytosolic protein subcellular compartment in each of the four species, suggesting that Hg was not well detoxified. By combining bioaccumulation studies with other physiological measures, we can begin to better understand the consequences of trace metal pollutants in nature.}, number={3}, journal={ENVIRONMENTAL SCIENCE & TECHNOLOGY}, author={Xie, Lingtian and Flippin, Jennifer L. and Deighton, Nigel and Funk, David H. and Dickey, David A. and Buchwalter, David B.}, year={2009}, month={Feb}, pages={934–940} }
 @article{passador-gurgel_hsieh_hunt_deighton_gibson_2007, title={Quantitative trait transcripts for nicotine resistance in Drosophila melanogaster}, volume={39}, ISSN={["1061-4036"]}, DOI={10.1038/ng1944}, abstractNote={Although most genetic association studies are performed with the intention of detecting nucleotide polymorphisms that are correlated with a complex trait, transcript abundance should also be expected to associate with diseases or phenotypes. We performed a scan for such quantitative trait transcripts in adult female heads of the fruit fly (Drosophila melanogaster) that might explain variation for nicotine resistance. The strongest association was seen for abundance of ornithine aminotransferase transcripts, implicating detoxification and neurotransmitter biosynthesis as mediators of the quantitative response to the drug. Subsequently, genetic analysis and metabolite profiling confirmed a complex role for ornithine and GABA levels in modification of survival time upon chronic nicotine exposure. Differences between populations from North Carolina and California suggest that the resistance mechanism may be an evolved response to environmental exposure.}, number={2}, journal={NATURE GENETICS}, author={Passador-Gurgel, Gisele and Hsieh, Wen-Ping and Hunt, Priscilla and Deighton, Nigel and Gibson, Greg}, year={2007}, month={Feb}, pages={264–268} }