2009 journal article

Mercury(II) Bioaccumulation and Antioxidant Physiology in Four Aquatic Insects


By: L. Xie n, J. Flippin n, N. Deighton n, D. Funk n, D. Dickey n & D. Buchwalter n

MeSH headings : Animals; Antioxidants / metabolism; Insecta / metabolism; Mercury / metabolism; Species Specificity; Subcellular Fractions / metabolism; Water Pollutants, Chemical / metabolism
TL;DR: Surprisingly, little Hg (<10%) was found in the heat-stable cytosolic protein subcellular compartment in each of the four species, suggesting that Hg was not well detoxified. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Predictive Modeling of a Mixture of Thyroid Hormone Disrupting Chemicals That Affect Production and Clearance of Thyroxine


By: J. Flippin n, J. Hedge n, M. DeVito n, G. LeBlanc n & K. Crofton n

author keywords: thyroid hormone disruption; mixture modeling; pronamide; mancozeb; thiram; polyhalogenated aromatic hydrocarbons
MeSH headings : Animals; Cytochrome P-450 CYP1A1 / metabolism; Cytochrome P-450 CYP2B1 / metabolism; Dose-Response Relationship, Drug; Endocrine Disruptors / chemistry; Endocrine Disruptors / toxicity; Female; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Models, Biological; Pesticides / chemistry; Pesticides / toxicity; Predictive Value of Tests; Rats; Rats, Long-Evans; Thyroid Gland / drug effects; Thyroid Gland / metabolism; Thyroxine / biosynthesis; Thyroxine / blood; Thyroxine / metabolism
TL;DR: The hypothesis that serum T4 concentrations of rodents exposed to a mixture of both TH synthesis inhibitors and stimulators of T4 clearance in the liver could be best predicted by an integrated addition model is tested and the use of dose- and integrated additivity models in predicting the effects of complex mixtures are supported. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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