Phosphatidylinositol (4,5)Bisphosphate Inhibits K+-Efflux Channel Activity in NT1 Tobacco Cultured Cells
Ma, X., Shor, O., Diminshtein, S., Yu, L., Im, Y. J., Perera, I., … Moran, N. (2008, December 3). PLANT PHYSIOLOGY, Vol. 149, pp. 1127–1140.
MeSH headings : Abscisic Acid / pharmacology; Calcium / pharmacology; Calcium / physiology; Cells, Cultured; Drosophila Proteins / drug effects; Drosophila Proteins / physiology; Kinetics; Phosphatidylinositol 4,5-Diphosphate / metabolism; Phosphatidylinositol 4,5-Diphosphate / pharmacology; Potassium / physiology; Potassium Channel Blockers / pharmacology; Potassium Channels / drug effects; Potassium Channels / physiology; Potassium Channels, Tandem Pore Domain / antagonists & inhibitors; Potassium Channels, Tandem Pore Domain / physiology; Tobacco / cytology; Tobacco / drug effects; Tobacco / physiology
topics (OpenAlex): Ion channel regulation and function; Adenosine and Purinergic Signaling; Trace Elements in Health
TL;DR:
Short-term manipulations decreasing PtdInsP2 levels in the High PIs, such as pretreatment with the phytohormone abscisic acid or neutralizing the bath solution from pH 5.6 to pH 7, increased IK (i.e. Ntork activity), consistent with NtORK inhibition by the negatively charged PtdinsP2 in the internal plasma membrane leaflet.
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UN Sustainable Development Goal Categories
3. Good Health and Well-being
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Sources: Web Of Science, NC State University Libraries