Works (7)

Updated: July 5th, 2023 15:50

2014 journal article

Data-driven modeling reconciles kinetics of ERK phosphorylation, localization, and activity states

MOLECULAR SYSTEMS BIOLOGY, 10(1).

By: S. Ahmed n, K. Grant n, L. Edwards n, A. Rahman n, M. Cirit n, M. Goshe n, J. Haugh n

author keywords: growth factor receptors; mitogen-activated protein kinases; negative feedback; nucleocytoplasmic shuttling; mathematical model
MeSH headings : Active Transport, Cell Nucleus; Animals; Extracellular Signal-Regulated MAP Kinases / chemistry; Extracellular Signal-Regulated MAP Kinases / metabolism; Feedback, Physiological; Kinetics; Mice; Models, Theoretical; NIH 3T3 Cells; Phosphorylation; Protein Transport / genetics; Receptors, Growth Factor / genetics; Signal Transduction / genetics
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Data-driven modelling of receptor tyrosine kinase signalling networks quantifies receptor-specific potencies of PI3K-and Ras-dependent ERK activation

BIOCHEMICAL JOURNAL, 441(1), 77–85.

By: M. Cirit n & J. Haugh n

author keywords: computational biology; cross-talk; growth factor; kinetic analysis; mitogen-activated protein kinase (MAPK); receptor tyrosine kinase
MeSH headings : Animals; Becaplermin; Computer Simulation; Extracellular Signal-Regulated MAP Kinases / genetics; Extracellular Signal-Regulated MAP Kinases / metabolism; Fibroblast Growth Factor 2 / genetics; Fibroblast Growth Factor 2 / metabolism; Fibroblasts / metabolism; Gene Expression Regulation, Enzymologic; Humans; Kinetics; Mice; Models, Biological; NIH 3T3 Cells; Phosphatidylinositol 3-Kinases / genetics; Phosphatidylinositol 3-Kinases / metabolism; Proto-Oncogene Proteins c-sis / genetics; Proto-Oncogene Proteins c-sis / metabolism; Receptor Protein-Tyrosine Kinases / genetics; Receptor Protein-Tyrosine Kinases / metabolism; Receptors, Fibroblast Growth Factor / genetics; Receptors, Fibroblast Growth Factor / metabolism; Signal Transduction
Sources: Web Of Science, ORCID
Added: August 6, 2018

2012 journal article

Systemic Perturbation of the ERK Signaling Pathway by the Proteasome Inhibitor, MG132

PLOS ONE, 7(11).

By: M. Cirit n, K. Grant n & J. Haugh n

Ed(s): L. Buday

MeSH headings : Animals; Computer Simulation; Dual-Specificity Phosphatases / metabolism; Embryo, Mammalian / cytology; Enzyme Activation / drug effects; Fibroblast Growth Factors / pharmacology; Fibroblasts / cytology; Fibroblasts / drug effects; Fibroblasts / enzymology; Humans; Leupeptins / pharmacology; MAP Kinase Signaling System / drug effects; Mesoderm / cytology; Mice; Mitogen-Activated Protein Kinase Kinases / metabolism; NIH 3T3 Cells; Phosphorylation / drug effects; Platelet-Derived Growth Factor / pharmacology; Proteasome Inhibitors / pharmacology; Up-Regulation / drug effects
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 journal article

Allosteric Modulation of Ras-GTP Is Linked to Signal Transduction through RAF Kinase

JOURNAL OF BIOLOGICAL CHEMISTRY, 286(5), 3323–3331.

By: G. Buhrman*, V. Kumar, M. Cirit n, J. Haugh n & C. Mattos*

MeSH headings : Allosteric Regulation; Allosteric Site; Animals; Guanosine Triphosphate / metabolism; Kinetics; Mice; Mutation, Missense; NIH 3T3 Cells; Protein Conformation; Protein Stability; Signal Transduction; raf Kinases / metabolism; ras Proteins / genetics; ras Proteins / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2011 article

PI3K-dependent cross-talk interactions converge with Ras as quantifiable inputs integrated by Erk (vol 5, pg 246, 2009)

Wang, C.-C., Cirit, M., & Haugh, J. M. (2011, August). MOLECULAR SYSTEMS BIOLOGY, Vol. 7.

By: C. Wang n, M. Cirit n & J. Haugh n

Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Stochastic Model of Integrin-Mediated Signaling and Adhesion Dynamics at the Leading Edges of Migrating Cells

PLOS COMPUTATIONAL BIOLOGY, 6(2).

By: M. Cirit n, M. Krajcovic n, C. Choi*, E. Welf n, A. Horwitz* & J. Haugh n

Ed(s): A. Asthagiri

MeSH headings : Animals; CHO Cells; Cell Adhesion / physiology; Cell Movement / physiology; Cell Surface Extensions / metabolism; Computational Biology / methods; Computer Simulation; Cricetinae; Cricetulus; Extracellular Matrix / metabolism; Green Fluorescent Proteins / genetics; Green Fluorescent Proteins / metabolism; Integrins / metabolism; Models, Biological; Myosins / metabolism; Paxillin / genetics; Paxillin / metabolism; Signal Transduction / physiology; Stochastic Processes; rac GTP-Binding Proteins / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018

2010 journal article

Systematic Quantification of Negative Feedback Mechanisms in the Extracellular Signal-regulated Kinase (ERK) Signaling Network

JOURNAL OF BIOLOGICAL CHEMISTRY, 285(47), 36736–36744.

By: M. Cirit n, C. Wang n & J. Haugh n

MeSH headings : Animals; Extracellular Signal-Regulated MAP Kinases / metabolism; Feedback, Physiological; Humans; Immunoblotting; Kinetics; Mice; Mitogen-Activated Protein Kinases / metabolism; NIH 3T3 Cells; Phosphorylation; Signal Transduction; ras Proteins / metabolism
Sources: Web Of Science, ORCID
Added: August 6, 2018