A. J. Harris

Works (3)

Updated: July 5th, 2023 15:49

2011 article

A facile synthesis of 1,5-disubstituted-2-aminoimidazoles: Antibiotic activity of a first generation library

Harris, T. L., Worthington, R. J., & Melander, C. (2011, June 25). Bioorganic & Medicinal Chemistry Letters.

By: T. Harris n, R. Worthington n & C. Melander n

author keywords: 2-Aminoimidazole; Amino aldehyde; Biofilm; Antibiotic
MeSH headings : Anti-Bacterial Agents / chemical synthesis; Anti-Bacterial Agents / chemistry; Anti-Bacterial Agents / pharmacology; Drug Resistance, Multiple, Bacterial / drug effects; Imidazoles / chemical synthesis; Imidazoles / chemistry; Imidazoles / pharmacology; Microbial Sensitivity Tests; Structure-Activity Relationship
topics (OpenAlex): Bacterial biofilms and quorum sensing; Antimicrobial agents and applications; Synthesis and Characterization of Heterocyclic Compounds
TL;DR: An efficient synthetic route to 1,5-disubstituted 2-aminoimidazoles from readily available amino acids and aldehydes has been developed and several compounds were shown to exhibit notable antibiotic activity against a variety of bacterial strains including multi-drug resistant isolates. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2009 journal article

Estimating ancestral distributions of lineages with uncertain sister groups: a statistical approach to Dispersal-Vicariance Analysis and a case using Aesculus L. (Sapindaceae) including fossils

Journal of Systematics and Evolution, 47(5), 349–368.

By: A. Harris n & Q. Xiang n 

author keywords: Aesculus; biogeography; DIVA; fossil wildcards; MrBayes; phylogenetic uncertainty
topics (OpenAlex): Ecology and Vegetation Dynamics Studies; Evolution and Paleontology Studies; Plant Diversity and Evolution
TL;DR: The DIVA‐Bayes approach to infer biogeographic histories without fully bifurcating trees was tested using Aesculus L., which has major lineages unresolved as a polytomy, and it was found that adding fossil wildcard taxa in phylogenetic analysis generally increased P for ancestral ranges including the fossil's distribution area. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2009 journal article

Phylogeny, origin, and biogeographic history of Aesculus L. (Sapindales) - an update from combined analysis of DNA sequences, morphology, and fossils

Taxon, 58(1), 108–126.

By: A. Harris, Q. Xiang  & D. Thomas

Source: NC State University Libraries
Added: August 6, 2018

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