Prashant Gupta

Works (3)

Updated: July 5th, 2023 16:04

1999 article

Computer simulation of the competition between protein folding and aggregation

Gupta, P., Hall, C. K., & Voegler, A. (1999, June). FLUID PHASE EQUILIBRIA, Vol. 158, pp. 87–93.

By: P. Gupta n, C. Hall n  & A. Voegler n

author keywords: protein folding; protein aggregation; folding pathways; folding intermediates; computer simulation
TL;DR: It is found that there exists optimum levels of denaturant and protein concentration at which the refolding yield is highest, in agreement with some experimental observations. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1998 journal article

Effect of denaturant and protein concentrations upon protein refolding and aggregation: A simple lattice model

PROTEIN SCIENCE, 7(12), 2642–2652.

By: P. Gupta n, C. Hall n  & A. Voegler n

author keywords: computer simulation; folding intermediates; folding pathways; protein aggregation; protein folding
MeSH headings : Models, Chemical; Models, Molecular; Monte Carlo Method; Protein Denaturation; Protein Folding; Proteins / chemistry
TL;DR: The aggregation reaction dominates over the folding reaction at high protein concentration and low denaturant concentration, resulting in low refolding yields at those conditions, however, optimum folding conditions exist at which the refolding yield is a maximum, in agreement with some experimental observations. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1997 journal article

Effect of solvent conditions upon refolding pathways and intermediates for a simple lattice protein

BIOPOLYMERS, 42(4), 399–409.

By: P. Gupta n & C. Hall n 

author keywords: protein folding; folding pathways; folding intermediates; computer simulation; solvent effects
TL;DR: Folding pathways and intermediates for a two‐dimensional lattice protein have been investigated via computer simulation at various denaturant concentrations and are observed to be cooperative in nature in that the chain does not start folding until a key fold in the middle section of the chain is formed correctly. (via Semantic Scholar)
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UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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