Stacy M. Branch

Works (12)

Updated: July 5th, 2023 16:02

2004 journal article

Chemically induced supernumerary lumbar ribs in CD-1 mice: Size distribution and dose response

BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY, 71(1), 17–25.

By: J. Rogers *, R. Setzer *, S. Branch n & N. Chernoff*

author keywords: supernumerary lumbar ribs; CD-1 mice; size distribution
MeSH headings : 2,4-Dinitrophenol / analogs & derivatives; 2,4-Dinitrophenol / toxicity; Abnormalities, Drug-Induced / epidemiology; Abnormalities, Drug-Induced / pathology; Animals; Benomyl / toxicity; Dose-Response Relationship, Drug; Embryonic and Fetal Development / drug effects; Ethylene Glycols / toxicity; Lumbosacral Region / abnormalities; Mice; Ribs / abnormalities; Teratogens / toxicity; Valproic Acid / toxicity
TL;DR: Data support the idea that extra and rudimentary SNR may reflect separate developmental phenomena, and should be considered and reported separately in developmental toxicity studies for risk assessment. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2003 journal article

5-AZA-2 '-deoxycytidine (5-AZA-CdR): a demethylating agent affecting development and reproductive capacity

JOURNAL OF APPLIED TOXICOLOGY, 23(2), 115–120.

By: F. Cisneros n & S. Branch n

author keywords: 5-aza-2 '-deoxycytidine; developmental toxicity; infertility; reproductive toxicity; reproductive capacity; DNA methylation; post-natal development; 5-AZA-CdR
MeSH headings : Analysis of Variance; Animals; Azacitidine / analogs & derivatives; Azacitidine / toxicity; Body Constitution / physiology; Body Weight / drug effects; DNA Modification Methylases / antagonists & inhibitors; Decitabine; Embryonic and Fetal Development / drug effects; Epididymis / drug effects; Epididymis / pathology; Female; Genitalia, Female / drug effects; Male; Mice; Pregnancy / drug effects; Reproduction / drug effects; Spermatids / drug effects; Testis / drug effects; Testis / pathology; Testosterone / blood
TL;DR: In 5‐AZA‐CdR F1 male mice, all measured reproductive parameters are significantly lower than the controls except for the number of spermatid heads per milligram of testis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2003 journal article

Susceptibility to postnatal growth retardation induced by 5- Aza-2 '-deoxycytidine in utero: Gender specificity and correlation with reduced insulin-like growth factor 1

Life Sciences (Oxford, England), 72(25), 2887–2894.

By: F. Cisneros, R. Wilson, G. Travlos, L. Anderson & S. Branch

Source: NC State University Libraries
Added: August 6, 2018

2003 journal article

Transplacental exposure to the DNA demethylating agent, 5-AZA-CdR, affects the sexual behavior of CD-1 male mice

NEUROTOXICOLOGY, 25(3), 411–417.

By: F. Cisneros* & S. Branch n

author keywords: 5-AZA-2 '-deoxycytidine (5-AZA-CdR); daily sperm production; Sry gene; reproductive behavior; reproductive toxicity
MeSH headings : Animals; Azacitidine / analogs & derivatives; Azacitidine / toxicity; DNA Methylation / drug effects; Decitabine; Female; Male; Maternal-Fetal Exchange / drug effects; Maternal-Fetal Exchange / physiology; Mice; Pregnancy; Reaction Time / drug effects; Sexual Behavior, Animal / drug effects; Sexual Behavior, Animal / physiology
TL;DR: In utero exposed male mice resulted in diminished mating behavior and reduced sexual interest while exposed to a receptive female suggesting that the reproductive alteration could be attributed to a behavioral phenomenon. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

Embryotoxicity of the pesticide mirex in vitro

TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS, 22(4), 239–249.

By: A. El-Bayomy n, I. Smoak n & S. Branch n

author keywords: insecticide; early somite mouse embryo; whole-embryo culture; organogenesis; xylene
MeSH headings : Abnormalities, Drug-Induced / embryology; Abnormalities, Drug-Induced / etiology; Animals; Apoptosis / drug effects; Cell Division / drug effects; Embryo, Mammalian / drug effects; Embryo, Mammalian / ultrastructure; Embryonic and Fetal Development / drug effects; Female; Fetal Proteins / biosynthesis; Gestational Age; In Vitro Techniques; Insecticides / toxicity; Mice; Mirex / toxicity; Proliferating Cell Nuclear Antigen / analysis; Somites / drug effects; Yolk Sac / blood supply; Yolk Sac / drug effects
TL;DR: Mirex is embryotoxic in vitro to early organogenesis stage mouse embryos at concentrations > or =100 microg/ml, but the effects do not appear to be mediated by changes in cell proliferation or apoptotic cell death. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2001 journal article

Altered Hox gene expression and cellular pathogenesis of 5-aza-2 '-deoxycytidine-induced murine hindlimb dysmorphogenesis

TOXICOLOGIC PATHOLOGY, 29(5), 501–506.

By: S. Branch n & G. Henry-Sam*

author keywords: homeobox; teratology; reverse transcription-polymerase chain reaction; morphological defects; DNA; mouse embryo; zeugopod; limb bud
MeSH headings : Abnormalities, Drug-Induced / etiology; Animals; Azacitidine / administration & dosage; Azacitidine / analogs & derivatives; Azacitidine / toxicity; DNA Primers / chemistry; Decitabine; Electrophoresis, Agar Gel; Female; Gene Expression Regulation, Developmental / drug effects; Gene Expression Regulation, Developmental / genetics; Gestational Age; Hindlimb / abnormalities; Hindlimb / drug effects; Homeodomain Proteins / genetics; Injections, Intraperitoneal; Limb Buds / abnormalities; Limb Buds / drug effects; Mice; Pregnancy; RNA, Messenger / metabolism; Rats; Reverse Transcriptase Polymerase Chain Reaction; Teratogens / toxicity; Transcriptional Activation
TL;DR: The hypothesis that altered gene expression and not cytotoxicity alone is associated with d-AZA-induced hindlimb dysmorphogenesis is supported. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Glut-1 expression and its response to hypoglycemia in the embryonic mouse heart

ANATOMY AND EMBRYOLOGY, 201(5), 327–333.

By: I. Smoak n & S. Branch n

author keywords: glucose uptake; cardiac development; organogenesis
MeSH headings : Age Factors; Animals; Blotting, Western; Cytochalasin B / pharmacology; Deoxyglucose / pharmacology; Electrophoresis, Polyacrylamide Gel; Embryo, Mammalian; Female; Glucose / metabolism; Glucose / pharmacology; Glucose Transporter Type 1; Heart / drug effects; Heart / embryology; Hypoglycemia / metabolism; Hypoglycemia / physiopathology; Immunohistochemistry; Mice; Mice, Inbred Strains; Monosaccharide Transport Proteins / genetics; Monosaccharide Transport Proteins / metabolism; Myocardium / metabolism; Pregnancy; RNA, Messenger / metabolism; Reverse Transcriptase Polymerase Chain Reaction; Time Factors; Tritium
TL;DR: The importance of Glut-1 during normal cardiogenesis and in response to hypoglycemia in the embryonic heart is supported and is correlated with changes in cardiac glucose requirements during normal organogenesis. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

5-AZA-2 '-deoxycytidine-induced dysmorphogenesis in the rat

TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS, 19(5), 329–338.

By: S. Branch n, N. Chernoff*, C. Brownie n & B. Francis*

author keywords: interspecies differences; teratogenicity; limb malformations; axial skeletal malformations; cytidine analog
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Expression of glucose-regulated proteins (GRP78 and GRP94) in hearts and fore-limb buds of mouse embryos exposed to hypoglycemia in vitro

CELL STRESS & CHAPERONES, 4(4), 250–258.

By: J. Barnes n, I. Smoak* & S. Branch*

TL;DR: Overall, these data demonstrate the preferential induction of GRPs in the heart as compared to fore-limb buds in mouse embryos exposed to hypoglycemia, suggesting increases in GRP protein levels may be a more reliable biomarker of stress than message levels. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

1999 journal article

Hexokinase I expression and activity in embryonic mouse heart during early and late organogenesis

HISTOCHEMISTRY AND CELL BIOLOGY, 112(5), 359–365.

By: H. Fritz n, I. Smoak n & S. Branch n

MeSH headings : Animals; Blotting, Western; Electrophoresis, Polyacrylamide Gel; Female; Gestational Age; Glycolysis; Heart / embryology; Hexokinase / biosynthesis; Immunohistochemistry; Mice; Myocardium / enzymology; Pregnancy; RNA, Messenger / biosynthesis; Reverse Transcriptase Polymerase Chain Reaction
TL;DR: A complex regulation of HK-I expression and activity in the embryonic heart during organogenesis is suggested, involving a change in the intrinsic activity of the enzyme with development. (via Semantic Scholar)
UN Sustainable Development Goal Categories
2. Zero Hunger (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

1998 journal article

Differentially expressed genes associated with 5-Aza-2'-deoxycytidine-induced hindlimb defects in the Swiss Webster mouse

Journal of Biochemical and Molecular Toxicology, 12(3), 135–141.

By: S. Branch n, B. Francis*, M. Rosen *, C. Brownie n, G. Held* & N. Chernoff*

TL;DR: Findings suggest that the isolated clones may have roles in abnormal embryonic development when inappropriately expressed, and methylation alterations in genes specific for fore‐ or hindlimbs may contribute to the observed pattern of defects. (via Semantic Scholar)
Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Infectious dermatitis in a ball python (Python regius) colony

Journal of Zoo and Wildlife Medicine, 29(4), 461–464.

By: S. Branch, L. Hall, P. Blackshear & N. Chernoff

Source: NC State University Libraries
Added: August 6, 2018

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