@article{haschek_berenbaum_hinton_cora_chernoff_travlos_liu_lu_law_2019, title={Pathology in Ecological Research With Implications for One Health: Session Summary}, volume={47}, ISSN={["1533-1601"]}, DOI={10.1177/0192623319880530}, abstractNote={ This session explored the effects of pollutants on One Health at the ecosystem level that included microbes, insects, fish, and humans. The concept of One Health seeks to synergize medical, veterinary, and other health science disciplines to more effectively advance human and animal health. Presentations explored the interactions of pesticides, pathogens, phytochemicals, and xenobiotic biotransformation in bee colony losses critical for food security (bees have been recently listed under the 2017 US Food and Drug Administration (FDA) veterinary feed directive); the role of pathology in identifying the effects of pollutants on fish as sentinels for human health; the effects in rats of per- and polyfluoroalkyl substances (PFAS) that can persist in the environment and contaminate drinking water; harmful algal blooms and toxin production leading to animal and human disease; and the processing of environmental carcinogens by intestinal microbiota. }, number={8}, journal={TOXICOLOGIC PATHOLOGY}, author={Haschek, Wanda M. and Berenbaum, May and Hinton, David E. and Cora, Michelle and Chernoff, Neil and Travlos, Gregory and Liu, Chih-Wei and Lu, Kun and Law, Mac}, year={2019}, month={Dec}, pages={1072–1075} } @article{rogers_setzer_branch_chernoff_2004, title={Chemically induced supernumerary lumbar ribs in CD-1 mice: Size distribution and dose response}, volume={71}, ISSN={["1542-9733"]}, DOI={10.1002/bdrb.10055}, abstractNote={AbstractSupernumerary ribs (SNR) of differing sizes are commonly observed in rodent developmental toxicity studies, and the significance of treatment‐related increases in SNR in standard studies has been contentious. We induced dose‐related increases in SNR in fetal CD‐1 mice by treating on gestation days 7–8 with benomyl (BEN; 0, 75, 150 mg/kg/d), dinoseb (DIN; 0, 30, 50 mg/kg/d); 2‐methoxyethanol (2‐ME; 0, 75, 150 mg/kg/d), or valproic acid (VPA; 0, 125, 250 mg/kg/d). Incidences of SNR were 9.3–27.6% in controls and 19.3–84.4% in the high dosage groups. SNR length showed a bimodal distribution with peaks at 0.3–0.4 mm and 0.9–1.1 mm in both treated and control groups. Based on length distributions, we used an actual length of 0.6 mm to separate short (rudimentary) from long (extra) SNR. DIN, 2‐ME, and VPA induced a dose‐related increase of extra ribs, while the incidence of rudimentary ribs remained at control levels. There was no apparent correlation of the presence of either type of SNR in a fetus and the occurrence of other anomalies. These data support the idea that extra and rudimentary SNR may reflect separate developmental phenomena, and should be considered and reported separately in developmental toxicity studies for risk assessment.Birth Defects Res B 71:17–25, 2004. Published 2004 Wiley‐Liss, Inc.}, number={1}, journal={BIRTH DEFECTS RESEARCH PART B-DEVELOPMENTAL AND REPRODUCTIVE TOXICOLOGY}, author={Rogers, JM and Setzer, RW and Branch, S and Chernoff, N}, year={2004}, month={Feb}, pages={17–25} } @article{cherrington_chernoff_2002, title={Periods of vertebral column sensitivity to boric acid treatment in CD-1 mice in utero}, volume={16}, number={3}, journal={Reproductive Toxicology (Elmsford, N.Y.)}, author={Cherrington, J. W. and Chernoff, N.}, year={2002}, pages={237–243} } @article{branch_chernoff_brownie_francis_1999, title={5-AZA-2 '-deoxycytidine-induced dysmorphogenesis in the rat}, volume={19}, ISSN={["0270-3211"]}, DOI={10.1002/(sici)1520-6866(1999)19:5<329::aid-tcm3>3.3.co;2-j}, abstractNote={5-aza-2′-deoxycytidine (d-AZA) causes temporally related defects in the developing mouse. Treatment of 1.0 mg/kg on gestation day (GD) 8 results in axial skeletal defects; on GD9, cleft palate and vertebral defects; on GD10, hindlimb phocomelia; and on GD11, digital defects. An unusual aspect of d-AZA teratogenicity in mice is that the phocomelia appears to be specific to the hindlimb, and the forelimb is not similarly affected regardless of treatment day. The current study was initiated to evaluate the embryonic response of another species, the rat, to this unique teratogen. Pregnant Sprague Dawley (CD) rats were treated with d-AZA or vehicle control. The compound was administered i.p. on GD9, 10, 11, or 12 to parallel developmental staging of the mouse. The highest dose (1.0 mg/kg) elicited effects indicating increased sensitivity to the compound in the rat as compared to the mouse. GD9 treatment was characterized by massive resorptions; GD10, by a predominance of axial skeletal defects and cleft palate; GD11, by a predominance of forelimb phocomelia and missing ribs; and GD12 by hindlimb phocomelia and forelimb digit defects. These data indicate significant differences in the developmental responses to d-AZA of the mouse and the rat. This may reflect interspecies differences in the temporal expression of genes involved in morphogenesis and/or the methylation patterns of such genes. Molecular data generated in the mouse will be compared to that of the rat to further characterize the developmental dynamics responsible for the interspecies differences. Teratogenesis Carcinog. Mutagen. 19:329–338, 1999. © 1999 Wiley-Liss, Inc.}, number={5}, journal={TERATOGENESIS CARCINOGENESIS AND MUTAGENESIS}, author={Branch, S and Chernoff, N and Brownie, C and Francis, BM}, year={1999}, pages={329–338} } @article{branch_hall_blackshear_chernoff_1998, title={Infectious dermatitis in a ball python (Python regius) colony}, volume={29}, number={4}, journal={Journal of Zoo and Wildlife Medicine}, author={Branch, S. and Hall, L. and Blackshear, P. and Chernoff, N.}, year={1998}, pages={461–464} }