Works (5)
Updated: July 5th, 2023 15:50
2013 journal article
Prenatal Bisphenol A Exposure Alters Sex-Specific Estrogen Receptor Expression in the Neonatal Rat Hypothalamus and Amygdala
TOXICOLOGICAL SCIENCES, 133(1), 157–173.
author keywords: brain; endocrine disruptor; endocrine disruption; hypothalamus; development; sexually dimorphic; ethinyl estradiol
MeSH headings : Amygdala / drug effects; Amygdala / growth & development; Amygdala / metabolism; Animals; Animals, Newborn; Benzhydryl Compounds / toxicity; Dose-Response Relationship, Drug; Endocrine Disruptors / toxicity; Estrogen Receptor alpha / genetics; Estrogen Receptor beta / genetics; Female; Gene Expression Regulation, Developmental / drug effects; Hypothalamus / drug effects; Hypothalamus / growth & development; Hypothalamus / metabolism; Male; Phenols / toxicity; Pregnancy; Prenatal Exposure Delayed Effects / chemically induced; Prenatal Exposure Delayed Effects / genetics; Prenatal Exposure Delayed Effects / metabolism; Rats; Rats, Sprague-Dawley; Receptors, Estrogen / genetics; Sex Factors
TL;DR:
Results indicate that ESR expression in the neonatal brain of both sexes can be altered by low-dose prenatal BPA exposure, and the potential for gavage to influence geneexpression in the developing brain is highlighted.
(via Semantic Scholar)
open access via europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(OpenAlex)
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2012 journal article
Disrupted Organization of RFamide Pathways in the Hypothalamus Is Associated with Advanced Puberty in Female Rats Neonatally Exposed to Bisphenol A
BIOLOGY OF REPRODUCTION, 87(2).
author keywords: endocrine disruptor; kisspeptin; puberty; RFRP
MeSH headings : Animals; Benzhydryl Compounds; Body Weight / drug effects; Estrogens, Non-Steroidal / toxicity; Female; Gonadotropin-Releasing Hormone / metabolism; Hypothalamus / drug effects; Kisspeptins / metabolism; Male; Neuropeptides / metabolism; Phenols / toxicity; Puberty, Precocious / blood; Puberty, Precocious / chemically induced; Rats; Rats, Transgenic; Rats, Wistar; Vagina / drug effects
TL;DR:
Data suggest that BPA-induced premature puberty results from decreased inhibition of GnRH neurons, which are critical for initiating puberty and maintaining estrous cyclicity by stimulating gonadotropin-releasing hormone (GnRH) release.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Neonatal exposure to genistein adversely impacts the ontogeny of hypothalamic kisspeptin signaling pathways and ovarian development in the peripubertal female rat
REPRODUCTIVE TOXICOLOGY, 31(3), 280–289.
author keywords: Soy; Estrogen; Phytoestrogens; Endocrine disruptors; Development; Reproductive; Fertility; Ovary
MeSH headings : Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / metabolism; Arcuate Nucleus of Hypothalamus / pathology; Female; Gene Expression Regulation, Developmental / drug effects; Genistein / toxicity; Hypothalamus / drug effects; Hypothalamus / metabolism; Immunohistochemistry; In Situ Hybridization; Kisspeptins; Midline Thalamic Nuclei / drug effects; Midline Thalamic Nuclei / metabolism; Midline Thalamic Nuclei / pathology; Ovary / drug effects; Ovary / growth & development; Phytoestrogens / toxicity; Proteins / genetics; Proteins / metabolism; RNA, Messenger / analysis; Rats; Rats, Long-Evans; Rats, Wistar; Sex Factors; Sexual Maturation / drug effects; Sexual Maturation / physiology; Signal Transduction / drug effects
TL;DR:
Female rats exposed to the phytoestrogen genistein, estradiol benzoate, or vehicle from post natal day (P) 0-3 via subcutaneous injection were exposed to estrogenic endocrine disrupting compounds to establish sex specific development of KISS gene expression, cell number and neural fiber density across peripuberty.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
The impact of neonatal bisphenol-A exposure on sexually dimorphic hypothalamic nuclei in the female rat
NEUROTOXICOLOGY, 32(1), 38–49.
author keywords: Xenoestrogen; Endocrine disruption; Brain; Sexual differentiation; Development; Estrogen receptor; Neuroendocrine
MeSH headings : Age Factors; Animals; Animals, Newborn; Arcuate Nucleus of Hypothalamus / drug effects; Arcuate Nucleus of Hypothalamus / growth & development; Benzhydryl Compounds; Body Weight / drug effects; Body Weight / physiology; Female; Phenols / toxicity; Preoptic Area / drug effects; Preoptic Area / growth & development; Rats; Rats, Long-Evans; Sex Characteristics; Sexual Behavior, Animal / drug effects; Sexual Behavior, Animal / physiology; Ventromedial Hypothalamic Nucleus / drug effects; Ventromedial Hypothalamic Nucleus / growth & development
TL;DR:
The results of this and a prior study indicate that the impact of neonatal BPA Exposure within the female rat hypothalamus is region specific and support the hypothesis that developmental BPA exposure may adversely affect reproductive development in females.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2009 journal article
Impact of neonatal exposure to the ERα agonist PPT, bisphenol-A or phytoestrogens on hypothalamic kisspeptin fiber density in male and female rats
NeuroToxicology, 30(3), 350–357.
author keywords: Bisphenol; Phytoestrogens; Soy; Genistein; Equal; Gonadotropins; Development; Disruption; Estrogen; Estrogen receptor; GnRH; KISS
MeSH headings : Animals; Animals, Newborn; Benzhydryl Compounds; Estradiol / analogs & derivatives; Estradiol / pharmacology; Estrogen Receptor alpha / agonists; Female; Hypothalamus / anatomy & histology; Kisspeptins; Male; Nerve Fibers / drug effects; Nerve Fibers / metabolism; Ovariectomy; Phenols / pharmacology; Phytoestrogens / pharmacology; Progesterone / pharmacology; Proteins / metabolism; Pyrazoles / pharmacology; Rats; Rats, Long-Evans; Sex Characteristics
TL;DR:
The results suggest that the organization of hypothalamic KISS fibers may be vulnerable to disruption by EDC exposure and that females might be more sensitive than males.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
6. Clean Water and Sanitation
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
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