2010 journal article

Human variation in CYP-specific chlorpyrifos metabolism

TOXICOLOGY, 276(3), 184–191.

By: E. Croom*, A. Wallace* & E. Hodgson*

author keywords: Chlorpyrifos; CYP isoform; Desulfuration; Dearylation; Human liver microsomes; Organophosphorothioate pesticides
MeSH headings : Animals; Aryl Hydrocarbon Hydroxylases / metabolism; Cell Line; Chlorpyrifos / metabolism; Chlorpyrifos / toxicity; Cytochrome P-450 CYP2B6; Cytochrome P-450 CYP2C19; Cytochrome P-450 CYP3A / metabolism; Cytochrome P-450 Enzyme System / genetics; Cytochrome P-450 Enzyme System / metabolism; Humans; Insecticides / metabolism; Insecticides / toxicity; Isoenzymes / genetics; Isoenzymes / metabolism; Microsomes, Liver / drug effects; Microsomes, Liver / enzymology; Oxidoreductases, N-Demethylating / metabolism; Substrate Specificity / drug effects; Substrate Specificity / physiology
TL;DR: Individual variations in CPO production may need to be considered in determining the risk of chlorpyrifos poisoning, and the combination of ketoconazole and ticlopidine inhibited the majority of TCP and CPO formation. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2009 journal article

Human hepatic CYP2B6 developmental expression: The impact of age and genotype


By: E. Croom n, J. Stevens*, R. Hines*, A. Wallace n & E. Hodgson n

author keywords: CYP450; Ontogeny; CYP2B6; CYP3A; Hepatic
MeSH headings : Adolescent; Age Factors; Aryl Hydrocarbon Hydroxylases / biosynthesis; Aryl Hydrocarbon Hydroxylases / chemistry; Aryl Hydrocarbon Hydroxylases / genetics; Child; Child, Preschool; Cytochrome P-450 CYP2B6; Female; Gene Expression Regulation, Developmental / physiology; Gene Expression Regulation, Enzymologic / physiology; Genotype; Humans; Infant; Male; Microsomes, Liver / enzymology; Oxidoreductases, N-Demethylating / biosynthesis; Oxidoreductases, N-Demethylating / chemistry; Oxidoreductases, N-Demethylating / genetics
TL;DR: Hepatic CYP2B6 protein levels were characterized in microsomal protein preparations isolated from a pediatric liver bank and showed consistency with different mechanisms controlling the ontogeny and constitutive expression of these enzymes and the lack of significant induction in the pediatric samples. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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