@article{goldman_breitschwerdt_grindem_hegarty_walls_dumler_1998, title={Granulocytic Ehrlichiosis in Dogs from North Carolina and Virginia}, volume={12}, ISSN={0891-6640 1939-1676}, url={http://dx.doi.org/10.1111/j.1939-1676.1998.tb02096.x}, DOI={10.1111/j.1939-1676.1998.tb02096.x}, abstractNote={Medical records of 3 dogs from North Carolina and 3 dogs from Virginia with ehrlichial morulae in circulating neutrophils were studied retrospectively. Two clinically distinct disease syndromes, including chronic, moderate to severe anemia (n = 3) and polyarthritis (n = 2) were associated with canine granulocytic ehrlichiosis (CGE) in these dogs. One dog was clinically healthy, and abnormalities were not detected during physical examination. Clinical signs were nonspecific and included fever, lethargy, anorexia, vomiting, and diarrhea. The most frequent laboratory abnormalities were normocytic normochromic nonregenerative anemia, moderate thrombocytopenia with large platelets, lymphopenia, and eosinopenia. Considerable variability was found in the serologic responses toEhrlichia equi, Ehrlichia canis, andEhrlichia chaffeensisantigens among the 5 dogs for which stored sera were available for indirect fluorescent antibody testing. Polymerase chain reaction amplification and sequencing of portions of the 16S rRNA gene from blood (collected in ethylenediaminetetraacetic acid) of 1 severely anemic dog (dog 3) and 1 polyarthritic dog (dog 4) resulted in DNA sequences nearly identical to the GenBank accessions forEhrlichia ewingii.The DNA sequence from a 3rd dog (dog 5) was most similar to that ofE. canis.Serologic or molecular results support the possibility ofE. ewingii, E. equi, andE. caniscoinfection or serologic cross‐reactivity among canine granulocytic and monocyticEhrlichiaspecies in dogs from North Carolina and Virginia. Variability in response to tetracycline or doxycycline treatment was noted in these dogs, with more rapid resolution of signs in dogs with polyarthritis. We report the 1st cases of CGE in dogs from North Carolina and Virginia, including recognition of CGE in a healthy dog.}, number={2}, journal={Journal of Veterinary Internal Medicine}, publisher={Wiley}, author={Goldman, Elizabeth E. and Breitschwerdt, Edward B. and Grindem, Carol B. and Hegarty, Barbara C. and Walls, Jennifer J. and Dumler, J. Stephen}, year={1998}, month={Mar}, pages={61–70} }
 @article{goldman_grindem_mcdorman_vancamp_1998, title={Uterine fluid from a mare}, volume={27}, ISSN={["1939-165X"]}, DOI={10.1111/j.1939-165X.1998.tb01074.x}, abstractNote={Veterinary Clinical PathologyVolume 27, Issue 1 p. 15-25 Uterine Fluid from a Mare Dr. Elizabeth E. Goldman BS, DVM, Dr. Elizabeth E. Goldman BS, DVM Department of Microbiology, Parasitology, and Pathology, North Carolina State University, Raleigh, NC 27606. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011.Search for more papers by this authorDr. Carol B. Grindem DVM, PhD, Corresponding Author Dr. Carol B. Grindem DVM, PhD Department of Microbiology, Parasitology, and Pathology, North Carolina State University, Raleigh, NC 27606.*at North Carolina State University.Search for more papers by this authorKevin S. McDorman DVM, Kevin S. McDorman DVM Department of Microbiology, Parasitology, and Pathology, North Carolina State University, Raleigh, NC 27606.Search for more papers by this authorSteven VanCamp DVM, Steven VanCamp DVM Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606.Search for more papers by this author Dr. Elizabeth E. Goldman BS, DVM, Dr. Elizabeth E. Goldman BS, DVM Department of Microbiology, Parasitology, and Pathology, North Carolina State University, Raleigh, NC 27606. Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011.Search for more papers by this authorDr. Carol B. Grindem DVM, PhD, Corresponding Author Dr. Carol B. Grindem DVM, PhD Department of Microbiology, Parasitology, and Pathology, North Carolina State University, Raleigh, NC 27606.*at North Carolina State University.Search for more papers by this authorKevin S. McDorman DVM, Kevin S. McDorman DVM Department of Microbiology, Parasitology, and Pathology, North Carolina State University, Raleigh, NC 27606.Search for more papers by this authorSteven VanCamp DVM, Steven VanCamp DVM Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh, NC 27606.Search for more papers by this author First published: 23 February 2009 https://doi.org/10.1111/j.1939-165X.1998.tb01074.xCitations: 1 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinked InRedditWechat Citing Literature Volume27, Issue1March 1998Pages 15-25 RelatedInformation}, number={1}, journal={VETERINARY CLINICAL PATHOLOGY}, author={Goldman, EE and Grindem, CB and McDorman, KS and VanCamp, S}, year={1998}, pages={15-+} }
 @article{goldman_grindem_1997, title={What is your diagnosis? Seven-year-old dog with progressive lethargy and inappetence - Chronic lymphocytic leukemia of T cell origin}, volume={26}, ISSN={["0275-6382"]}, DOI={10.1111/j.1939-165X.1997.tb00734.x}, abstractNote={Veterinary Clinical PathologyVolume 26, Issue 4 p. 187-187 Seven-Year-Old Dog With Progressive Lethargy and Inappetence Elizabeth E. Goldman, Elizabeth E. Goldman Department of Microbiology, Parasitology, and Pathology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606 Department of Veterinary Clinical Science, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011.Search for more papers by this authorCarol B. Grindem, Carol B. Grindem Department of Microbiology, Parasitology, and Pathology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606Search for more papers by this author Elizabeth E. Goldman, Elizabeth E. Goldman Department of Microbiology, Parasitology, and Pathology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606 Department of Veterinary Clinical Science, College of Veterinary Medicine, Iowa State University, Ames, Iowa 50011.Search for more papers by this authorCarol B. Grindem, Carol B. Grindem Department of Microbiology, Parasitology, and Pathology, College of Veterinary Medicine, North Carolina State University, Raleigh, North Carolina 27606Search for more papers by this author First published: 23 February 2009 https://doi.org/10.1111/j.1939-165X.1997.tb00734.xCitations: 2 AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onEmailFacebookTwitterLinkedInRedditWechat REFERENCES 1 Grindem CB: Ultrastructural Morphology of Leukemic Cells From 14 Dogs. Vet Pathol 22: 456–462, 1985. 2 Jain NC: Essentials of Veterinary Hematology. Lea & Febiger, Philadelphia, 1993, pp 333–335. 3 Ogilvie GK, Moore AS: Managing the Veterinary Cancer Patient. Veterinary Learning Systems Co., Inc., Trenton, 1995, pp 271–273. 4 Hodgkins EM, Zinkl JG, Madewell BR: Chronic Lymphocytic Leukemia in the Dog. JAVMA 177: 704–707, 1980. 5 Leifer CE, Matus RE: Chronic Lymphocytic Leukemia in the Dog: 22 Cases (1974–1984). JAVMA 189: 214–217, 1986. 6 Wellman ML, Couto CG, Starkey RJ, et al: Lymphocytosis of Large Granular Lymphocytes in 3 Dogs. Vet Pathol 26: 158–163, 1989. 7 Willard MD, Krehbiel JD, Schmidt GM, et al: Serum and Urine Protein Abnormalities Associated With Lymphocytic Leukemia and Glomerulonephritis in a Dog. JAAHA 17: 381–386, 1981. 8 Weiser MG, Thrall MA, Fulton R., et al: Granular Lymphocytosis and Hyperproteinemia in Dogs With Chronic Ehrlichiosis. JAAHA 27: 84–88, 1991. 9 Melo JV, Catovsky D., Galton DAG: The Relationship Between Chronic Lymphocytic Leukaemia and Prolymphocytic Leukaemia. I. Clinical and Laboratory Features of 300 Patients and Characterization of an Intermediate Group. British Journal of Hematology 63: 377–387, 1986. 10 Novotney CA, Gebhard DH, Page RL, et al: Immunophenotypic Characterization of Canine Chronic Lymphocytic Leukemia. In: Proceedings of the 10th Annual Conference of the Veterinary Cancer Society, p 22, 1991. 11 Moore PF, Rossetto PV, Danilenko DM, et al: Monoclonal Antibodies Specific for Canine CD4 and CD8 Define Functional T-lymphocyte Subsets and High Density Expression of CD4 by Canine Neutrophils. Tissue Antigens 40: 75, 1992. Citing Literature Volume26, Issue4December 1997Pages 187-187 ReferencesRelatedInformation}, number={4}, journal={VETERINARY CLINICAL PATHOLOGY}, author={Goldman, EE and Grindem, CB}, year={1997}, pages={187-+} }