Christine S. Hughes

Works (3)

Updated: February 10th, 2025 16:10

2000 journal article

Modulation of P-glycoprotein-mediated doxorubicin resistance in canine cell lines

Anticancer Research, 20(5B), 3533–3538.

By: R. Page, C. Hughes, S. Huyan, J. Sagris & M. Trogdon

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Characterization of canine MDR1 mRNA: Its abundance in drug resistant cell lines and in vivo

Anticancer Research, 18(1A), 393–400.

By: S. Steingold, N. Sharp, M. McGahan, C. Hughes, S. Dunn & R. Page

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

Modulation of doxorubicin concentration by cyclosporin A in brain and testicular barrier tissues expressing P-glycoprotein in rats

JOURNAL OF NEURO-ONCOLOGY, 37(1), 45–54.

By: C. Hughes n, S. Vaden n , C. Manaugh n, G. Price n & L. Hudson n

author keywords: cyclosporin A; blood-tissue barrier; P-glycoprotein; multidrug resistance; doxorubicin; cisplatin
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis; Animals; Blood-Brain Barrier / drug effects; Brain / drug effects; Brain / metabolism; Cisplatin / administration & dosage; Cisplatin / pharmacology; Cyclosporine / administration & dosage; Cyclosporine / pharmacology; Doxorubicin / pharmacokinetics; Evans Blue / pharmacokinetics; Fluorescein / pharmacokinetics; Horseradish Peroxidase / pharmacokinetics; Injections, Intravenous; Injections, Subcutaneous; Male; Platinum / pharmacokinetics; Rats; Rats, Inbred F344; Testis / drug effects; Testis / metabolism; Tissue Distribution / drug effects
TL;DR: Modulation of Pgp function may prove to be useful for improving chemotherapy efficacy for patients with malignancies affecting tissues with blood-tissue barriers. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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