Works (3)
Updated: March 10th, 2025 12:14
2000 journal article
Modulation of P-glycoprotein-mediated doxorubicin resistance in canine cell lines
Anticancer Research, 20(5B), 3533–3538.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Characterization of canine MDR1 mRNA: Its abundance in drug resistant cell lines and in vivo
Anticancer Research, 18(1A), 393–400.
Source: NC State University Libraries
Added: August 6, 2018
1998 article
Modulation of doxorubicin concentration by cyclosporin A in brain and testicular barrier tissues expressing P-glycoprotein in rats
Hughes, C. S., Vaden, S. L., Manaugh, C. A., Price, G. S., & Hudson, L. C. (1998, March 1). Journal of Neuro-Oncology, Vol. 37, pp. 45–54.
author keywords: cyclosporin A; blood-tissue barrier; P-glycoprotein; multidrug resistance; doxorubicin; cisplatin
MeSH headings : ATP Binding Cassette Transporter, Subfamily B, Member 1 / biosynthesis; Animals; Blood-Brain Barrier / drug effects; Brain / drug effects; Brain / metabolism; Cisplatin / administration & dosage; Cisplatin / pharmacology; Cyclosporine / administration & dosage; Cyclosporine / pharmacology; Doxorubicin / pharmacokinetics; Evans Blue / pharmacokinetics; Fluorescein / pharmacokinetics; Horseradish Peroxidase / pharmacokinetics; Injections, Intravenous; Injections, Subcutaneous; Male; Platinum / pharmacokinetics; Rats; Rats, Inbred F344; Testis / drug effects; Testis / metabolism; Tissue Distribution / drug effects
topics (OpenAlex): Drug Transport and Resistance Mechanisms; Pharmacological Effects and Toxicity Studies; Pregnancy and Medication Impact
TL;DR:
Modulation of Pgp function may prove to be useful for improving chemotherapy efficacy for patients with malignancies affecting tissues with blood-tissue barriers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018