Terameprocol, a methylated derivative of nordihydroguaiaretic acid, inhibits production of prostaglandins and several key inflammatory cytokines and chemokines
Eads, D., Hansen, R. L., Oyegunwa, A. O., Cecil, C. E., Culver, C. A., Scholle, F., … Laster, S. M. (2009, January 8). Journal of Inflammation, Vol. 6.
topics (OpenAlex): Plant-derived Lignans Synthesis and Bioactivity; Peroxisome Proliferator-Activated Receptors; Drug-Induced Hepatotoxicity and Protection
TL;DR:
TMP inhibited the LPS-induced production of lipid mediators and several key inflammatory cytokines and chemokines, both in vitro and in vivo, raising the possibility that TMP might be useful as a treatment for a variety of inflammatory disorders.
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