Works (3)

Updated: July 5th, 2023 15:49

2019 journal article

Design and evaluation of engineered protein biosensors for live-cell imaging of EGFR phosphorylation


By: K. Tiruthani n, A. Mischler n, S. Ahmed*, J. Mahinthakumar n, J. Haugh n & B. Rao n

MeSH headings : Animals; Biosensing Techniques; Cell Line; Endocytosis; ErbB Receptors / genetics; ErbB Receptors / metabolism; Mice; Microscopy, Fluorescence; Phospholipase C gamma / genetics; Phospholipase C gamma / metabolism; Phosphorylation / genetics; src Homology Domains
TL;DR: The authors used two different mutagenesis and screening approaches to engineer new biosensors, mSH2 and SPY992, that exhibited greater specificity for EGFR Tyr992 and more accurately reported EGFR signaling kinetics, and could be extended to generate phospho-specific biosensor for various targets. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: June 24, 2019

2017 journal article

Inefficient Ribosomal Skipping Enables Simultaneous Secretion and Display of Proteins in Saccharomyces cerevisiae

ACS SYNTHETIC BIOLOGY, 6(11), 2096–2107.

By: C. Cruz-Teran n, K. Tiruthani n, A. Mischler n & B. Rao n

author keywords: yeast surface display; secretion; ribosomal skipping; 2A peptide; Sso7d; glucose oxidase
MeSH headings : Cell Adhesion Molecules / genetics; Cell Adhesion Molecules / metabolism; Gene Expression; Peptide Library; Peptides / genetics; Peptides / metabolism; Recombinant Proteins / biosynthesis; Recombinant Proteins / genetics; Saccharomyces cerevisiae / genetics; Saccharomyces cerevisiae / metabolism; Saccharomyces cerevisiae Proteins / genetics; Saccharomyces cerevisiae Proteins / metabolism
TL;DR: A system for simultaneous cell surface display and soluble secretion of proteins in Saccharomyces cerevisiae based on inefficient ribosomal skipping is described and it is shown that binding proteins derived from the Sso7d scaffold and the homodimeric enzyme glucose oxidase can be simultaneously secreted solubly and displayed on the cell surface. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

2009 journal article

A Capacitive Displacement Sensing Technique for Early Detection of Unbalanced Loads in a Washing Machine

SENSORS, 9(12), 9559–9571.

By: M. Ramasubramanian n & K. Tiruthani n

author keywords: capacitive-displacement-sensor; horizontal-axis-washing-machine; vibration-detection
TL;DR: A displacement-based sensing method to detect unbalance early while the spin rate is well below the resonance frequency so that corrective actions may be taken prior to the high speed spin cycle. (via Semantic Scholar)
UN Sustainable Development Goal Categories
7. Affordable and Clean Energy (OpenAlex)
Source: Web Of Science
Added: August 6, 2018

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