@misc{brown_brown-jenco_payne_1999, title={Genetic and molecular analysis of aflatoxin biosynthesis}, volume={26}, ISSN={["1096-0937"]}, DOI={10.1006/fgbi.1998.1114}, abstractNote={The aflatoxin biosynthetic pathway represents one of the est studied pathways of fungal secondary metabolism. Its lucidation is the result of over 30 years of study by cientists in many disciplines. For recent reviews on the hemistry of the pathway see articles by Bhatnagar et al. 1992) Minto and Townsend (1997), and Woloshuk and rieto (1997). Concern over the toxicity and carcinogenicty of aflatoxin has been the prime force driving research in his area. Aflatoxin B1 (AFB1) is the most potent naturally ccurring carcinogen known (Squire, 1989), and epidemioogical data implicate aflatoxin as a component of liver ancer in humans in certain parts of the world (Hall and ild, 1994). Although aflatoxins are not extremely toxic, onsumption of aflatoxin contaminated food by animals can ead to decreased weight gain, hemorrhaging, and suppression f the immune system (Miller and Wilson, 1994). Aflatoxins are produced by four species of Aspergillus: . flavus, A. parasiticus, A. nomius, and A. tamarii (Payne, 998; Kurtzman et al., 1986; Goto et al., 1996). From an gricultural standpoint, the two most significant fungi are}, number={2}, journal={FUNGAL GENETICS AND BIOLOGY}, author={Brown, MP and Brown-Jenco, CS and Payne, GA}, year={1999}, month={Mar}, pages={81–98} }
 @misc{payne_brown_1998, title={Genetics and physiology of aflatoxin biosynthesis}, volume={36}, ISSN={["1545-2107"]}, DOI={10.1146/annurev.phyto.36.1.329}, abstractNote={ ▪ Abstract  Aflatoxins are the most thoroughly studied mycotoxins. Elegant early research on the biosynthetic scheme of the pathway has allowed a molecular characterization of aflatoxin biosynthesis and its regulation. Genetic studies on aflatoxin biosynthesis in Aspergillus flavus and A. parasiticus, and sterigmatocystin biosynthesis in A. nidulans, led to the cloning of 17 genes responsible for 12 enzymatic conversions in the AF/ST pathways. Pathway-specific regulation is by a Zn(II)2Cys6 DNA-binding protein that regulates the transcription of all pathway genes. Less is known about the global factors that regulate aflatoxin biosynthesis, but there is a clear link between development and aflatoxin biosynthesis. There is also a large body of information on physiological factors involved in aflatoxin biosynthesis, but it has been difficult to understand their role in the regulation of this pathway. This chapter discusses current knowledge on the molecular biology and genetics of the pathway, and provides a summary of the physiological factors known to influence aflatoxin formation. }, journal={ANNUAL REVIEW OF PHYTOPATHOLOGY}, author={Payne, GA and Brown, MP}, year={1998}, pages={329–362} }