@article{davis_doane_knop_knop_dubielzig_colitz_argueso_sullivan_2013, title={Characterization of ocular gland morphology and tear composition of pinnipeds}, volume={16}, number={4}, journal={Veterinary Ophthalmology}, author={Davis, R. K. and Doane, M. G. and Knop, E. and Knop, N. and Dubielzig, R. R. and Colitz, C. M. H. and Argueso, P. and Sullivan, D. A.}, year={2013}, pages={269–275} }
 @article{davis_yi_salmon_charlton_colitz_gilger_2012, title={Sustained-Release Celecoxib from Incubated Acrylic Intraocular Lenses Suppresses Lens Epithelial Cell Growth in an Ex Vivo Model of Posterior Capsule Opacity}, volume={28}, ISSN={["1080-7683"]}, DOI={10.1089/jop.2011.0196}, abstractNote={PURPOSE
To determine whether celecoxib (CXB) can be released from incubated intraocular lenses (IOLs) sufficiently to inhibit lens epithelial cell (LEC) growth in an ex vivo model of posterior capsule opacification (PCO).


MATERIALS
LEC growth was evaluated for 14 days in canine lens capsules (LCs) that had been exposed to media containing 20 μM CXB for 1-5 days. After the incubation of hydrophilic and hydrophobic IOLs in CXB solution, the determination of the in vitro release of CXB from the IOLs was performed for up to 28 days. The incubated and nonincubated IOLs were evaluated in the ex vivo model of PCO, and the rate of LEC growth was evaluated over 28 days.


RESULTS
The treatment of LCs with 20 μM CXB for 4 and 5 days completely inhibited LEC growth. LEC repopulation did not occur after the removal of CXB. IOLs incubated in CXB for 24 h resulted in a sustained release of CXB in vitro at levels theoretically sufficient to inhibit PCO. LCs in the ex vivo model of PCO treated with acrylic IOLs incubated in CXB had significantly suppressed LEC ingrowth compared with untreated and IOL-only LCs.


CONCLUSIONS
A 4-day treatment of LCs with a concentration of 20 μM CXB may effectively prevent PCO. IOLs incubated in CXB for 24 h resulted in a sustained release of CXB in vitro at levels sufficient to inhibit LEC growth in the ex vivo model of PCO. Further studies are needed to determine whether CXB-incubated IOLs can effectively prevent the development of PCO in vivo.}, number={4}, journal={JOURNAL OF OCULAR PHARMACOLOGY AND THERAPEUTICS}, author={Davis, Jennifer L. and Yi, Na Young and Salmon, Jacklyn H. and Charlton, Anna N. and Colitz, Carmen M. H. and Gilger, Brian C.}, year={2012}, month={Aug}, pages={359–368} }
 @article{broadwater_colitz_carastro_saville_2010, title={Tear production in normal juvenile dogs}, volume={13}, number={5}, journal={Veterinary Ophthalmology}, author={Broadwater, J. J. and Colitz, C. and Carastro, S. and Saville, W.}, year={2010}, pages={321–325} }
 @article{goralska_nagar_colitz_fleisher_mcgahan_2009, title={Changes in Ferritin H- and L-Chains in Canine Lenses with Age-Related Nuclear Cataract}, volume={50}, ISSN={["0146-0404"]}, DOI={10.1167/iovs.08-2230}, abstractNote={PURPOSE
To determine potential differences in the characteristics of the iron storage protein ferritin and its heavy (H) and light (L) subunits in fiber cells from cataractous and noncataractous lenses of older dogs.


METHODS
Lens fiber cell homogenates were analyzed by SDS-PAGE, and ferritin chains were immunodetected with ferritin chain-specific antibodies. Ferritin concentration was measured by ELISA. Immunohistochemistry was used to localize ferritin chains in lens sections.


RESULTS
The concentration of assembled ferritin was comparable in noncataractous and cataractous lenses of similarly aged dogs. The ferritin L-chain detected in both lens types was modified and was approximately 11 kDa larger (30 kDa) than standard L-chain (19 kDa) purified from canine liver. The H-chain identified in cataractous fiber cells (29 kDa) differed from the 21-kDa standard canine H-chain and from the 12-kDa modified H-chain present in fiber cells of noncataractous lenses. Histologic analysis revealed that the H-chain was distributed differently throughout cataractous lenses compared with noncataractous lenses. There was also a difference in subunit makeup of assembled ferritin between the two lens types. Ferritin from cataractous lenses contained more H-chain and bound 11-fold more iron than ferritin from noncataractous lenses.


CONCLUSIONS
There are significant differences in the characteristics of ferritin H-chain and its distribution in canine cataractous lenses compared with noncataractous lenses. The higher content of H-chain in assembled ferritin allows this molecule to sequester more iron. In addition, the accumulation of H-chain in deeper fiber layers of the lens may be part of a defense mechanism by which the cataractous lens limits iron-catalyzed oxidative damage.}, number={1}, journal={INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE}, author={Goralska, Malgorzata and Nagar, Steven and Colitz, Carmen M. H. and Fleisher, Lloyd N. and McGahan, M. Christine}, year={2009}, month={Jan}, pages={305–310} }
 @article{gilger_salmon_yi_barden_chandler_wendt_colitz_2008, title={Role of bacteria in the pathogenesis of recurrent uveitis in horses from the southeastern United States}, volume={69}, ISSN={0002-9645}, url={http://dx.doi.org/10.2460/ajvr.69.10.1329}, DOI={10.2460/ajvr.69.10.1329}, abstractNote={Abstract}, number={10}, journal={American Journal of Veterinary Research}, publisher={American Veterinary Medical Association (AVMA)}, author={Gilger, Brian C. and Salmon, Jacklyn H. and Yi, Na Y. and Barden, Curtis A. and Chandler, Heather L. and Wendt, Jennifer A. and Colitz, Carmen M. H.}, year={2008}, month={Oct}, pages={1329–1335} }
 @article{colitz_davidson_gilger_2002, title={Bilateral proliferative keratitis in a Domestic Long-haired cat}, volume={5}, ISSN={["1463-5216"]}, DOI={10.1046/j.1463-5224.2002.00221.x}, abstractNote={Abstract}, number={2}, journal={VETERINARY OPHTHALMOLOGY}, author={Colitz, CMH and Davidson, MG and Gilger, BC}, year={2002}, month={Jun}, pages={137–140} }
 @article{colitz_lewbart_davidson_2002, title={Phacoemulsification in an adult Savannah monitor lizard}, volume={5}, ISSN={["1463-5216"]}, DOI={10.1046/j.1463-5224.2002.00233.x}, abstractNote={Abstract}, number={3}, journal={VETERINARY OPHTHALMOLOGY}, author={Colitz, CMH and Lewbart, G and Davidson, MG}, year={2002}, month={Sep}, pages={207–209} }
 @article{latimer_colitz_campbell_papich_2001, title={Pharmacokinetics of fluconazole following intravenous and oral administration and body fluid concentrations of fluconazole following repeated oral dosing in horses}, volume={62}, ISSN={["1943-5681"]}, DOI={10.2460/ajvr.2001.62.1606}, abstractNote={Abstract}, number={10}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Latimer, FG and Colitz, CMH and Campbell, NB and Papich, MG}, year={2001}, month={Oct}, pages={1606–1611} }
 @article{colitz_malarkey_dykstra_mcgahan_davidson_2000, title={Histologic and immunohistochemical characterization of lens capsular plaques in dogs with cataracts}, volume={61}, ISSN={["0002-9645"]}, DOI={10.2460/ajvr.2000.61.139}, abstractNote={Abstract}, number={2}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={Colitz, CMH and Malarkey, D and Dykstra, MJ and McGahan, MC and Davidson, MG}, year={2000}, month={Feb}, pages={139–143} }
 @article{hoppes_gurfield_flammer_colitz_fisher_2000, title={Mycotic keratitis in a blue-fronted Amazon parrot (Amazona aestiva)}, volume={14}, ISSN={["1082-6742"]}, DOI={10.1647/1082-6742(2000)014[0185:MKIABF]2.0.CO;2}, abstractNote={Abstract Mycotic keratitis is most commonly reported in horses and humans and is rarely reported in birds. We diagnosed mycotic keratitis, localized to the left eye, in an adult blue-fronted Amazon parrot (Amazona aestiva). The ophthalmic examination revealed a diffuse yellow-green haze encompassing the entire surface of the left cornea. Diffuse fluorescein uptake occurred in the entire cornea. The right eye appeared normal. Aspergillus fumigatus was isolated on conjunctival culture. The affected eye was enucleated because of the bird's discomfort and the poor prognosis for successful treatment. Histopathologic examination revealed a severe granulomatous keratitis with intracorneal fungal hyphae and corneal perforation. Multinucleated giant cells and fungal hyphae were present within the anterior chamber. Aspergillus fumigatus is an uncommon cause of keratitis in birds but should be considered as a potential cause of refractory ulcers.}, number={3}, journal={JOURNAL OF AVIAN MEDICINE AND SURGERY}, author={Hoppes, S and Gurfield, N and Flammer, K and Colitz, C and Fisher, P}, year={2000}, month={Sep}, pages={185–189} }
 @article{colitz_malarkey_woychik_wilkinson_2000, title={Persistent hyperplastic tunica vasculosa lentis and persistent hyperplastic primary vitreous in transgenic line TgN3261Rpw}, volume={37}, ISSN={["0300-9858"]}, DOI={10.1354/vp.37-5-422}, abstractNote={ Persistent hyperplastic tunica vasculosa lentis and persistent hyperplastic primary vitreous are congenital ocular anomalies that can lead to cataract formation. A line of insertional mutant mice, TgN3261Rpw, generated at the Oak Ridge National Laboratory in a large-scale insertional mutagenesis program was found to have a low incidence (8/243; 3.29%) of multiple developmental ocular abnormalities. The ocular abnormalities include persistent hyperplastic primary vitreous, persistent hyperplastic tunica vasculosa lentis, failure of cleavage of the anterior segment, retrolental fibrovascular membrane, posterior polar cataract, and detached retina. This transgenic mouse line provides an ontogenetic model because of the high degree of similarity of this entity in humans, dogs, and mice. }, number={5}, journal={VETERINARY PATHOLOGY}, author={Colitz, CMH and Malarkey, DE and Woychik, RP and Wilkinson, JE}, year={2000}, month={Sep}, pages={422–427} }
 @article{kordick_breitschwerdt_hegarty_southwick_colitz_hancock_bradley_rumbough_mcpherson_maccormack_1999, title={Coinfection with multiple tick-borne pathogens in a Walker Hound kennel in North Carolina}, volume={37}, number={8}, journal={Journal of Clinical Microbiology}, author={Kordick, S. K. and Breitschwerdt, E. B. and Hegarty, B. C. and Southwick, K. L. and Colitz, C. M. and Hancock, S. I. and Bradley, J. M. and Rumbough, R. and McPherson, J. T. and MacCormack, J. N.}, year={1999}, pages={2631–2638} }
 @article{colitz_davidson_mcgahan_1999, title={Telomerase activity in lens epithelial cells of normal and cataractous lenses}, volume={69}, ISSN={["0014-4835"]}, DOI={10.1006/exer.1999.0739}, abstractNote={Telomerase is a ribonucleoprotein responsible for maintaining telomere length, preventing chromosomal degradation and recombination, and repairing DNA strand breaks. These activities are believed to be important in preventing cell senescence. Telomerase activity is normally found in germinal, neoplastic and stem cells, but not any ocular tissue studied to date. The epithelium of the crystalline lens is comprised of a population of cells with diverse mitotic potential including the germinative epithelium which contains cells with the potential for unlimited replicative capacity, equatorial cells which terminally differentiate into lens fibers, and the central epithelium which are considered to be quiescent and nonreplicative under normal circumstances. We speculated that the germinative region of lens epithelial cells might have telomerase activity, and that dysregulation of its activity might be associated with cataractogenesis. We investigated these hypotheses in lens capsule specimens from normal and cataractous dogs and from cultures of canine lens epithelial cells using standard assays for telomerase activity and telomere length. Telomerase activity was found in normal canine lens epithelial cells in the central, germinative and equatorial regions of the anterior lens capsule at equivalent levels. Similar findings were made in feline and murine lens epithelial cells, indicating that the presence of telomerase activity in the lens was not species specific. Lens fiber cells, corneal epithelium and endothelium and nonpigmented ciliary epithelium were telomerase negative. Telomerase activity and telomere lengths were significantly greater in lens epithelia from cataractous lenses when compared with normal lenses. Since telomerase activity is associated with an immortal phenotype, the presence of telomerase activity in the lens epithelial cells may function to prevent conversion to senescence. It was, therefore, difficult to explain why these cells cannot be passaged more than four times in culture. We found that telomerase activity and telomere lengths gradually decreased with increased passages until telomerase activity was no longer present at passage two. Consistent with these findings, there were no senescent cells present on the lens capsule when the lens was initially dissected for culture, but an increasing number of cells were senescent with each passage, correlating well with the loss of telomerase activity. Telomerase activity is likely important in the germinative epithelium to maintain its proliferative potential and prevent cell senescence. Telomerase may function in the quiescent, central lens to maintain telomeres damaged by oxidative stress and ultraviolet light exposure, thereby preventing accelerated loss of these elements which triggers cell senescence. It remains to be determined if the increase in telomerase activity in lens epithelial cells from cataractous lenses is a primary dysregulation that may have a role in the development of the cataract, or is secondary to cataract formation.}, number={6}, journal={EXPERIMENTAL EYE RESEARCH}, author={Colitz, CMH and Davidson, MG and McGahan, MC}, year={1999}, month={Dec}, pages={641–649} }
 @article{gilger_davidson_colitz_1998, title={Experimental implantation of posterior chamber prototype intraocular lenses for the feline eye}, volume={59}, number={10}, journal={American Journal of Veterinary Research}, author={Gilger, B. C. and Davidson, M. G. and Colitz, C. M. H.}, year={1998}, month={Oct}, pages={1339–1343} }