Works (10)
Updated: July 5th, 2023 16:04
2001 article
Analysis of single nucleotide polymorphisms in candidate genes using the pedigree disequilibrium test
GENETIC EPIDEMIOLOGY, Vol. 21, pp. S441–S446.
author keywords: association; linkage disequilibrium; pedigree disequilibrium test; SNPs
MeSH headings : Genetic Predisposition to Disease / genetics; Genetics, Population; Genotype; Humans; Linkage Disequilibrium; Models, Genetic; Polymorphism, Single Nucleotide; Quantitative Trait, Heritable
TL;DR:
The results indicate that, using the pedigree disequilibrium test, functional disease‐associated SNPs can be successfully identified with a dense map of moderately polymorphic SNPs.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
2001 journal article
Issues concerning association studies for fine mapping a susceptibility gene for a complex disease
GENETIC EPIDEMIOLOGY, 20(4), 432–457.
author keywords: fine mapping; linkage disequilibrium; association test; TDT; coalescent process
MeSH headings : Case-Control Studies; Chi-Square Distribution; Chromosome Mapping; Gene Frequency; Genetic Markers; Genetic Predisposition to Disease; Haplotypes; Humans; Linkage Disequilibrium; Models, Genetic
TL;DR:
A simple strategy of choosing the marker with the smallest associated P value to begin a laboratory search for the disease locus performs adequately for a common disease allele, and a strategy of pooling nearby sites to form multiple allele markers is investigated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Two tests of association for a susceptibility locus for families of variable size: An example using two sampling strategies
Genetic Epidemiology, 17(Suppl.1), S655–660.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
A comparative study of sibship tests of linkage and/or association
AMERICAN JOURNAL OF HUMAN GENETICS, 63(5), 1507–1516.
MeSH headings : Alleles; Case-Control Studies; False Positive Reactions; Genetic Diseases, Inborn / genetics; Genetic Linkage; Genetic Markers; Models, Genetic; Models, Statistical; Monte Carlo Method; Nuclear Family; Parents; Research Design
TL;DR:
This paper proposes an extension of one of three recent family-based tests of association and linkage that utilize unaffected siblings as surrogates for untyped parents and describes and compares the four tests in the context of a complex disease for both biallelic and multialle Lic markers, as well as for sibships of different sizes.
(via Semantic Scholar)
doi.org (publisher)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1998 journal article
Marker selection for the transmission/disequilibrium test, in recently admixed populations
AMERICAN JOURNAL OF HUMAN GENETICS, 62(3), 703–712.
MeSH headings : Alleles; Gene Frequency; Genetics, Population; Humans; Linkage Disequilibrium; Models, Genetic
TL;DR:
The consequences of collapsing a microsatellite into a two-allele marker are examined, and it is found that if there is random mating in the admixed population, then typically there is a collapsing for which the power of the TDT is greater than that for the original micros Satellite marker.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1997 journal article
A Monte Carlo permutation approach to choosing an affection status model for bipolar affective disorder
Genetic Epidemiology, 14(6), 681–686.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Power studies for the transmission/disequilibrium tests with multiple alleles
American Journal of Human Genetics, 60(1997), 691–702.
Source: NC State University Libraries
Added: August 6, 2018
1997 journal article
Tests for linkage and association in nuclear families
AMERICAN JOURNAL OF HUMAN GENETICS, 61(2), 439–448.
MeSH headings : Alleles; Chi-Square Distribution; Child; Genetic Diseases, Inborn / genetics; Genetic Linkage; Genetic Markers; Genetic Predisposition to Disease; Humans; Linkage Disequilibrium; Models, Genetic; Monte Carlo Method; Nuclear Family; Reproducibility of Results
TL;DR:
Two statistics are proposed that give valid chi2 tests of the null hypothesis of no association or no linkage and generally are more powerful than the TDT with a single, randomly chosen, affected child from each family.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1997 personal communication
Transmission/disequilibrium tests for multiallelic loci: reply
Source: NC State University Libraries
Added: August 6, 2018
1992 journal article
A statistical test for detecting geographic subdivision
Molecular Biology and Evolution, 9(1), 138–151.
Source: NC State University Libraries
Added: August 6, 2018
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