Norman L. Kaplan

Works (10)

Updated: August 16th, 2024 13:38

2001 article

Analysis of single nucleotide polymorphisms in candidate genes using the pedigree disequilibrium test

GENETIC EPIDEMIOLOGY, Vol. 21, pp. S441–S446.

By: S. Hardy n, B. Weir n, N. Kaplan* & E. Martin *

author keywords: association; linkage disequilibrium; pedigree disequilibrium test; SNPs
MeSH headings : Genetic Predisposition to Disease / genetics; Genetics, Population; Genotype; Humans; Linkage Disequilibrium; Models, Genetic; Polymorphism, Single Nucleotide; Quantitative Trait, Heritable
TL;DR: The results indicate that, using the pedigree disequilibrium test, functional disease‐associated SNPs can be successfully identified with a dense map of moderately polymorphic SNPs. (via Semantic Scholar)
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Added: August 6, 2018

2001 journal article

Issues concerning association studies for fine mapping a susceptibility gene for a complex disease

GENETIC EPIDEMIOLOGY, 20(4), 432–457.

By: N. Kaplan* & R. Morris n

author keywords: fine mapping; linkage disequilibrium; association test; TDT; coalescent process
MeSH headings : Case-Control Studies; Chi-Square Distribution; Chromosome Mapping; Gene Frequency; Genetic Markers; Genetic Predisposition to Disease; Haplotypes; Humans; Linkage Disequilibrium; Models, Genetic
TL;DR: A simple strategy of choosing the marker with the smallest associated P value to begin a laboratory search for the disease locus performs adequately for a common disease allele, and a strategy of pooling nearby sites to form multiple allele markers is investigated. (via Semantic Scholar)
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1999 journal article

Two tests of association for a susceptibility locus for families of variable size: An example using two sampling strategies

Genetic Epidemiology, 17(Suppl.1), S655–660.

By: S. Monks, E. Martin, D. Umbach & N. Kaplan

Source: NC State University Libraries
Added: August 6, 2018

1998 journal article

A comparative study of sibship tests of linkage and/or association

AMERICAN JOURNAL OF HUMAN GENETICS, 63(5), 1507–1516.

By: S. Monks n, N. Kaplan* & B. Weir n

MeSH headings : Alleles; Case-Control Studies; False Positive Reactions; Genetic Diseases, Inborn / genetics; Genetic Linkage; Genetic Markers; Models, Genetic; Models, Statistical; Monte Carlo Method; Nuclear Family; Parents; Research Design
TL;DR: This paper proposes an extension of one of three recent family-based tests of association and linkage that utilize unaffected siblings as surrogates for untyped parents and describes and compares the four tests in the context of a complex disease for both biallelic and multialle Lic markers, as well as for sibships of different sizes. (via Semantic Scholar)
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1998 journal article

Marker selection for the transmission/disequilibrium test, in recently admixed populations

AMERICAN JOURNAL OF HUMAN GENETICS, 62(3), 703–712.

By: N. Kaplan*, E. Martin *, R. Morris  n & B. Weir*

MeSH headings : Alleles; Gene Frequency; Genetics, Population; Humans; Linkage Disequilibrium; Models, Genetic
TL;DR: The consequences of collapsing a microsatellite into a two-allele marker are examined, and it is found that if there is random mating in the admixed population, then typically there is a collapsing for which the power of the TDT is greater than that for the original micros Satellite marker. (via Semantic Scholar)
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1997 journal article

A Monte Carlo permutation approach to choosing an affection status model for bipolar affective disorder

Genetic Epidemiology, 14(6), 681–686.

By: K. Simonsen, N. Kaplan & E. Martin

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Power studies for the transmission/disequilibrium tests with multiple alleles

American Journal of Human Genetics, 60(1997), 691–702.

By: N. Kaplan, E. Martin & B. Weir

Source: NC State University Libraries
Added: August 6, 2018

1997 journal article

Tests for linkage and association in nuclear families

AMERICAN JOURNAL OF HUMAN GENETICS, 61(2), 439–448.

By: E. Martin  n, N. Kaplan* & B. Weir n

MeSH headings : Alleles; Chi-Square Distribution; Child; Genetic Diseases, Inborn / genetics; Genetic Linkage; Genetic Markers; Genetic Predisposition to Disease; Humans; Linkage Disequilibrium; Models, Genetic; Monte Carlo Method; Nuclear Family; Reproducibility of Results
TL;DR: Two statistics are proposed that give valid chi2 tests of the null hypothesis of no association or no linkage and generally are more powerful than the TDT with a single, randomly chosen, affected child from each family. (via Semantic Scholar)
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1997 personal communication

Transmission/disequilibrium tests for multiallelic loci: reply

By: N. Kaplan, E. Martin & B. Weir

Source: NC State University Libraries
Added: August 6, 2018

1992 journal article

A statistical test for detecting geographic subdivision

Molecular Biology and Evolution, 9(1), 138–151.

By: R. Hudson, D. Boos  & N. Kaplan

Source: NC State University Libraries
Added: August 6, 2018

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