@article{mcfarlane_sellon_gibbs_2001, title={Age-related quantitative alterations in lymphocyte subsets and immunoglobulin isotypes in healthy horses}, volume={62}, ISSN={["1943-5681"]}, DOI={10.2460/ajvr.2001.62.1413}, abstractNote={AbstractObjective—To characterize age-associated changes in lymphocyte population subsets and immunoglobulin isotypes.Animals—30 healthy young light-breed horses (5 to 12 years old) and 30 healthy aged light-breed horses (> 20 years old).Procedure—Lymphocyte subset populations were identified, using monoclonal antibodies to cell surface markers CD5, CD4, CD8, and IgG. Subset populations were quantitated by use of flow cytometric analysis of antibody-stained cells. Serum immunoglobulin concentration was determined using single radial immunodiffusion.Results—Absolute cell counts of total lymphocytes, T cells, CD4+and CD8+T cells, and B cells were decreased in aged horses, compared with young horses. There was a significant decrease in the percentage of CD8+cells and an increase in the CD4+-to- CD8+cell ratio in the aged population, compared with young horses. However, serum concentration of IgG, IgG(T), IgM, or IgA did not differ with age.Conclusions and Clinical Relevance—In horses, total lymphocyte count and lymphocyte subset cell counts decrease with age. Age-matched control values are necessary for optimal evaluation of hematologic variables in aged horses. The decrease in lymphocyte subset cell counts in healthy aged horses mimics that seen in other species and may contribute to an age-associated decrease in immunocompetency. (Am J Vet Res2001;62:1413–1417)}, number={9}, journal={AMERICAN JOURNAL OF VETERINARY RESEARCH}, author={McFarlane, D and Sellon, DC and Gibbs, SA}, year={2001}, month={Sep}, pages={1413–1417} } @article{zimmel_blikslager_jones_mcfarlane_young_2000, title={Vaccine-associated anaphylactic-like reaction in a horse}, volume={22}, number={1}, journal={Compendium on Continuing Education for the Practicing Veterinarian}, author={Zimmel, D. N. and Blikslager, A. T. and Jones, S. L. and McFarlane, D. and Young, K.}, year={2000}, month={Jan}, pages={81–84} } @article{mcfarlane_1999, title={Hetastarch: A synthetic colloid with potential in equine patients}, volume={21}, number={9}, journal={Compendium on Continuing Education for the Practicing Veterinarian}, author={McFarlane, D.}, year={1999}, pages={867} } @article{mcfarlane_guy_cornish_1998, title={Case presentation: Immunoperoxidase in formalin-fixed tissues to diagnose eastern equine encephalomyelitis}, volume={20}, number={3}, journal={Compendium on Continuing Education for the Practicing Veterinarian}, author={McFarlane, D. and Guy, J. and Cornish, T. E.}, year={1998}, pages={373–376} } @article{mcfarlane_sellon_gaffney_hedgpeth_papich_gibbs_1998, title={Hematologic and serum biochemical variables and plasma corticotropin concentration in healthy aged horses}, volume={59}, number={10}, journal={American Journal of Veterinary Research}, author={McFarlane, D. and Sellon, D. C. and Gaffney, D. and Hedgpeth, V. and Papich, M. and Gibbs, S.}, year={1998}, pages={1247–1251} } @article{mcfarlane_sellon_parker_1998, title={Primary erythrocytosis in a 2-year-old Arabian gelding}, volume={12}, ISSN={["0891-6640"]}, DOI={10.1111/j.1939-1676.1998.tb02139.x}, abstractNote={Journal of Veterinary Internal MedicineVolume 12, Issue 5 p. 384-388 Open Access Primary Erythrocytosis in a 2-Year-Old Arabian Gelding Dianne McFarlane, Corresponding Author Dianne McFarlane Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh, NC Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606; e-mail: [email protected]Search for more papers by this authorDebra C. Sellon, Debra C. Sellon Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh, NCSearch for more papers by this authorBert Parker, Bert Parker South Ridge Veterinary HospitalSearch for more papers by this author Dianne McFarlane, Corresponding Author Dianne McFarlane Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh, NC Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, 4700 Hillsborough Street, Raleigh, NC 27606; e-mail: [email protected]Search for more papers by this authorDebra C. Sellon, Debra C. Sellon Department of Food Animal and Equine Medicine, College of Veterinary Medicine, North Carolina State University, Raleigh, NCSearch for more papers by this authorBert Parker, Bert Parker South Ridge Veterinary HospitalSearch for more papers by this author First published: 05 February 2008 https://doi.org/10.1111/j.1939-1676.1998.tb02139.xCitations: 16 Dr Sellon is presently affiliated with the Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. 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