Works (2)

Updated: July 5th, 2023 15:48

2010 journal article

Interferon Regulatory Factor 3 Attenuates Reovirus Myocarditis and Contributes to Viral Clearance

JOURNAL OF VIROLOGY, 84(14), 6900–6908.

MeSH headings : Animals; Animals, Newborn; Cells, Cultured; Humans; Immunity; Interferon Regulatory Factor-3 / genetics; Interferon Regulatory Factor-3 / metabolism; Interferon-beta / genetics; Interferon-beta / metabolism; Liver / pathology; Liver / virology; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocarditis / immunology; Myocarditis / pathology; Myocarditis / virology; Myocytes, Cardiac / pathology; Myocytes, Cardiac / virology; Reoviridae / metabolism; Reoviridae / pathogenicity; Reoviridae Infections / immunology; Reoviridae Infections / pathology; Reoviridae Infections / virology; Spleen / pathology; Spleen / virology; Survival Rate; Tissue Distribution
TL;DR: Cellular and humoral immune responses were equivalent in wild-type and IRF-3−/− animals, suggesting that IRf-3 functions independently of the adaptive immune response to enhance reovirus clearance. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: August 6, 2018

2010 journal article

Proteomic Analysis Reveals Virus-Specific Hsp25 Modulation in Cardiac Myocytes


By: L. Li n, J. Sevinsky n, M. Rowland n, J. Bundy n, J. Stephenson n & B. Sherry n

author keywords: cardiac myocyte; myocarditis; reovirus; Hsp25; Hsp27; proteome; DIGE
MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Cell Nucleus / metabolism; Cells, Cultured; Cytoplasm / metabolism; Electrophoresis, Gel, Two-Dimensional; Fibroblasts / metabolism; Heat-Shock Proteins / metabolism; Interferons / metabolism; Mice; Molecular Chaperones; Myocarditis / metabolism; Myocarditis / virology; Myocardium / cytology; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / virology; Neoplasm Proteins / metabolism; Orthoreovirus, Mammalian; Phosphorylation; Principal Component Analysis; Proteomics / methods; Reoviridae Infections / metabolism; Reoviridae Infections / virology; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; p38 Mitogen-Activated Protein Kinases / metabolism
TL;DR: Results here provide the first evidence for a virus-induced decrease in Hsp25/27 and suggest that viruses may have evolved a mechanism to subvert this protective response, as they have for IFN. (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2024) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.