Lianna Li

MeSH headings : Animals; Animals, Newborn; Cells, Cultured; Humans; Immunity; Interferon Regulatory Factor-3 / genetics; Interferon Regulatory Factor-3 / metabolism; Interferon-beta / genetics; Interferon-beta / metabolism; Liver / pathology; Liver / virology; Mice; Mice, Inbred C57BL; Mice, Knockout; Myocarditis / immunology; Myocarditis / pathology; Myocarditis / virology; Myocytes, Cardiac / pathology; Myocytes, Cardiac / virology; Reoviridae / metabolism; Reoviridae / pathogenicity; Reoviridae Infections / immunology; Reoviridae Infections / pathology; Reoviridae Infections / virology; Spleen / pathology; Spleen / virology; Survival Rate; Tissue Distribution

TL;DR: Cellular and humoral immune responses were equivalent in wild-type and IRF-3−/− animals, suggesting that IRf-3 functions independently of the adaptive immune response to enhance reovirus clearance. (via Semantic Scholar)

author keywords: cardiac myocyte; myocarditis; reovirus; Hsp25; Hsp27; proteome; DIGE

MeSH headings : Analysis of Variance; Animals; Animals, Newborn; Blotting, Western; Cell Nucleus / metabolism; Cells, Cultured; Cytoplasm / metabolism; Electrophoresis, Gel, Two-Dimensional; Fibroblasts / metabolism; Heat-Shock Proteins / metabolism; Interferons / metabolism; Mice; Molecular Chaperones; Myocarditis / metabolism; Myocarditis / virology; Myocardium / cytology; Myocytes, Cardiac / metabolism; Myocytes, Cardiac / virology; Neoplasm Proteins / metabolism; Orthoreovirus, Mammalian; Phosphorylation; Principal Component Analysis; Proteomics / methods; Reoviridae Infections / metabolism; Reoviridae Infections / virology; Reproducibility of Results; Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization; p38 Mitogen-Activated Protein Kinases / metabolism

TL;DR: Results here provide the first evidence for a virus-induced decrease in Hsp25/27 and suggest that viruses may have evolved a mechanism to subvert this protective response, as they have for IFN. (via Semantic Scholar)