Karel A. Schat

author keywords: poult enteritis and mortality syndrome; reovirus; replication; immune response

MeSH headings : Animals; Antigens, Viral / analysis; B-Lymphocytes / metabolism; B-Lymphocytes / virology; Cell Line; Cells, Cultured; Chickens; Cytopathogenic Effect, Viral; Interleukin-1 / genetics; Interleukin-1 / metabolism; Liver / cytology; Liver / virology; Macrophages / metabolism; Macrophages / virology; Microscopy, Electron / veterinary; Orthoreovirus, Avian / growth & development; Orthoreovirus, Avian / immunology; Orthoreovirus, Avian / pathogenicity; Poult Enteritis Mortality Syndrome / metabolism; Poult Enteritis Mortality Syndrome / virology; Poultry Diseases / metabolism; Poultry Diseases / virology; RNA, Messenger / metabolism; Reoviridae Infections / veterinary; Reoviridae Infections / virology; Specific Pathogen-Free Organisms; T-Lymphocytes / metabolism; T-Lymphocytes / virology; Tumor Cells, Cultured; Turkeys; Virus Replication

TL;DR: It is demonstrated that ARV-CU98 actively infects and replicates in LMH cells, but not in lymphocytes or macrophages, suggesting that the liver may be a target and site of replication of ARV -CU98 in poults experiencing PEMS. (via Semantic Scholar)

author keywords: poult enteritis and mortality syndrome; reovirus; turkey; fecal filtrate

TL;DR: It is demonstrated that ARV-CU98 does cause some of the clinical signs in PEMS, including intestinal alterations and significantly lower relative bursa and liver weights. (via Semantic Scholar)