George W. Small

Works (2)

Updated: July 5th, 2023 16:02

2000 article

The ferritin iron entry and exit problem

Theil, E. C., Takagi, H., Small, G. W., He, L., Tipton, A. R., & Danger, D. (2000, January 1). Inorganica Chimica Acta.

By: E. Theil*, H. Takagi  n, G. Small n, L. He n, A. Tipton & D. Danger n

author keywords: ferritin; iron biominerals; ferroxidation; iron/dioxygen catalysis
topics (OpenAlex): Iron Metabolism and Disorders; Trace Elements in Health; Hemoglobinopathies and Related Disorders
TL;DR: The entry and exit of Fe(II) ions in ferritin are endpoints in the process which concentrates iron as a solid (hydrated ferric oxide) to be used by living cells, suggesting a regulation-sensitive biological signal for iron exit. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1999 article

Crystal structure of bullfrog M ferritin at 2.8 Å resolution: analysis of subunit interactions and the binuclear metal center

Ha, Y., Shi, D., Small, G. W., Theil, E. C., & Allewell, N. M. (1999, July 1). JBIC Journal of Biological Inorganic Chemistry.

By: Y. Ha*, D. Shi *, G. Small n, E. Theil n & N. Allewell *

author keywords: crystallography; iron oxidation; iron storage; multisubunit proteins
MeSH headings : Amino Acid Sequence; Animals; Aspartic Acid; Binding Sites; Conserved Sequence; Crystallography, X-Ray; Ferritins / chemistry; Ferritins / metabolism; Magnesium / metabolism; Models, Molecular; Molecular Sequence Data; Protein Conformation; Rana catesbeiana; Sequence Homology, Amino Acid; Tyrosine / analysis; Tyrosine / metabolism
topics (OpenAlex): Iron Metabolism and Disorders
TL;DR: The crystal structure of the homopolymer of recombinant frog M ferritin is determined and it is suggested that Gln137 and Asp140 are a vestige of the second GluxxHis site, resulting from single nucleotide mutations of Glu and His codons and giving rise to Ala140 or Ser140 present in other eukaryotic H-type ferritins, by additional singleucleotide mutations. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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