Works (6)
Updated: July 24th, 2023 21:15
2017 journal article
Genetics of Hereditary Ataxia in Scottish Terriers
Journal of Veterinary Internal Medicine, 31(4), 1132–1139.
author keywords: Canine; Cerebellar abiotrophy; Cerebellar ataxia; Neurodegeneration
MeSH headings : Animals; Brain / diagnostic imaging; Dog Diseases / diagnostic imaging; Dog Diseases / genetics; Dogs; Female; Genetic Linkage / genetics; Genome-Wide Association Study / veterinary; Homozygote; Magnetic Resonance Imaging / veterinary; Male; Neuroimaging / veterinary; Pedigree; Spinocerebellar Degenerations / diagnostic imaging; Spinocerebellar Degenerations / genetics; Spinocerebellar Degenerations / veterinary
TL;DR:
This finding suggests that further genetic investigation of the potential region of interest on CFA X should be considered in order to identify the causal mutation as well as develop a genetic test to eliminate the disease from this breed.
(via Semantic Scholar)
onlinelibrary.wiley.com (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2015 journal article
Clinical characteristics of Scottie Cramp in 31 cases
Journal of Small Animal Practice, 56(4), 276–280.
MeSH headings : Animals; Breeding; Cerebellum / pathology; Dog Diseases / drug therapy; Dog Diseases / genetics; Dog Diseases / physiopathology; Dogs; Female; Fluoxetine / therapeutic use; Genetic Predisposition to Disease; Male; Muscle Cramp / drug therapy; Muscle Cramp / genetics; Muscle Cramp / physiopathology; Muscle Cramp / veterinary; Muscle Hypertonia / drug therapy; Muscle Hypertonia / genetics; Muscle Hypertonia / physiopathology; Muscle Hypertonia / veterinary; Selective Serotonin Reuptake Inhibitors / therapeutic use; Severity of Illness Index; Sex Factors; Spinocerebellar Degenerations / genetics; Spinocerebellar Degenerations / physiopathology; Spinocerebellar Degenerations / veterinary
TL;DR:
The disorder recognised as Scottie Cramp by dog owners includes dogs with hind limb spasticity in addition to generalised cramping, which usually improve over time without specific treatment.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, Crossref, NC State University Libraries
Added: August 6, 2018
2014 journal article
Canine hereditary ataxia in Old English Sheepdogs and Gordon Setters is associated with a defect in the autophagy gene encoding RAB24
PLoS Genetics, 10(2).
Source: NC State University Libraries
Added: August 6, 2018
2013 journal article
Titanium-enriched hydroxyapatite-gelatin scaffolds with osteogenically differentiated progenitor cell aggregates for calvaria bone regeneration
Tissue Engineering. Part A, 19(15-16), 1803–1816.
Source: NC State University Libraries
Added: August 6, 2018
2012 journal article
Mapping of Purkinje Neuron Loss and Polyglucosan Body Accumulation in Hereditary Cerebellar Degeneration in Scottish Terriers
VETERINARY PATHOLOGY, 49(5), 852–859.
author keywords: dog; cerebellar abiotrophy; cerebellar ataxia; cerebellar cortex; inclusion; molecular layer; polyglucosan body
MeSH headings : Aging / pathology; Animals; Case-Control Studies; Cerebellar Cortex / metabolism; Cerebellar Cortex / pathology; Cerebellar Cortex / ultrastructure; Cerebellum / metabolism; Cerebellum / pathology; Cerebellum / ultrastructure; Dog Diseases / genetics; Dog Diseases / metabolism; Dog Diseases / pathology; Dogs; Female; Glucans / metabolism; Immunohistochemistry / veterinary; Inclusion Bodies / metabolism; Inclusion Bodies / pathology; Inclusion Bodies / ultrastructure; Male; Microscopy, Electron, Transmission / veterinary; Purkinje Cells / metabolism; Purkinje Cells / pathology; Purkinje Cells / ultrastructure; Spinocerebellar Degenerations / genetics; Spinocerebellar Degenerations / metabolism; Spinocerebellar Degenerations / pathology; Spinocerebellar Degenerations / veterinary
TL;DR:
Significant Purkinje cell loss and increased polyglucosan bodies in the cerebellum of affected Scottish Terriers are demonstrated.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2010 journal article
Hereditary Cerebellar Degeneration in Scottish Terriers
JOURNAL OF VETERINARY INTERNAL MEDICINE, 24(3), 565–570.
author keywords: Canine; Cerebellar abiotrophy; Cerebellar ataxia; Polyglucosan body; Purkinje cell
MeSH headings : Animals; Cerebellum / pathology; Dog Diseases / genetics; Dogs; Female; Genetic Predisposition to Disease; Male; Pedigree; Spinocerebellar Degenerations / genetics; Spinocerebellar Degenerations / veterinary
TL;DR:
A hereditary cerebellar degenerative disorder with a relatively mild phenotype has emerged in the Scottish Terrier and genetic analysis results are consistent with an autosomal recessive mode of inheritance.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
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