@article{mcwhinney-glass_winham_hertz_revollo_paul_he_brown_motsinger-reif_mcleod_2013, title={Cumulative genetic risk predicts platinum/taxane-induced neurotoxicity}, volume={19}, number={20}, journal={Clinical Cancer Research}, author={McWhinney-Glass, S. and Winham, S. J. and Hertz, D. L. and Revollo, J. Y. and Paul, J. and He, Y. J. and Brown, R. and Motsinger-Reif, A. A. and McLeod, H. L.}, year={2013}, pages={5769–5776} }
 @article{winham_wang_motsinger-reif_2011, title={A Comparison of Multifactor Dimensionality Reduction and L-1-Penalized Regression to Identify Gene-Gene Interactions in Genetic Association Studies}, volume={10}, ISSN={["1544-6115"]}, DOI={10.2202/1544-6115.1613}, abstractNote={Recently, the amount of high-dimensional data has exploded, creating new analytical challenges for human genetics. Furthermore, much evidence suggests that common complex diseases may be due to complex etiologies such as gene-gene interactions, which are difficult to identify in high-dimensional data using traditional statistical approaches. Data-mining approaches are gaining popularity for variable selection in association studies, and one of the most commonly used methods to evaluate potential gene-gene interactions is Multifactor Dimensionality Reduction (MDR). Additionally, a number of penalized regression techniques, such as Lasso, are gaining popularity within the statistical community and are now being applied to association studies, including extensions for interactions. In this study, we compare the performance of MDR, the traditional lasso with L1 penalty (TL1), and the group lasso for categorical data with group-wise L1 penalty (GL1) to detect gene-gene interactions through a broad range of simulations.}, number={1}, journal={STATISTICAL APPLICATIONS IN GENETICS AND MOLECULAR BIOLOGY}, author={Winham, Stacey and Wang, Chong and Motsinger-Reif, Alison A.}, year={2011} }
 @article{winham_motsinger-reif_2011, title={The Effect of Retrospective Sampling on Estimates of Prediction Error for Multifactor Dimensionality Reduction}, volume={75}, journal={Annals of Human Genetics}, author={Winham, S. J. and Motsinger-Reif, A. A.}, year={2011}, pages={46–61} }
 @article{winham_slater_motsinger-reif_2010, title={A comparison of internal validation techniques for multifactor dimensionality reduction}, volume={11}, journal={BMC Bioinformatics}, author={Winham, S. J. and Slater, A. J. and Motsinger-Reif, A. A.}, year={2010} }
 @misc{asher_jonas_coeytaux_reilly_loh_motsinger-reif_winham_2010, title={Auriculotherapy for Pain Management: A Systematic Review and Meta-Analysis of Randomized Controlled Trials}, volume={16}, ISSN={["1557-7708"]}, DOI={10.1089/acm.2009.0451}, abstractNote={OBJECTIVES
Side-effects of standard pain medications can limit their use. Therefore, nonpharmacologic pain relief techniques such as auriculotherapy may play an important role in pain management. Our aim was to conduct a systematic review and meta-analysis of studies evaluating auriculotherapy for pain management.


DESIGN
MEDLINE,(®) ISI Web of Science, CINAHL, AMED, and Cochrane Library were searched through December 2008. Randomized trials comparing auriculotherapy to sham, placebo, or standard-of-care control were included that measured outcomes of pain or medication use and were published in English. Two (2) reviewers independently assessed trial eligibility, quality, and abstracted data to a standardized form. Standardized mean differences (SMD) were calculated for studies using a pain score or analgesic requirement as a primary outcome.


RESULTS
Seventeen (17) studies met inclusion criteria (8 perioperative, 4 acute, and 5 chronic pain). Auriculotherapy was superior to controls for studies evaluating pain intensity (SMD, 1.56 [95% confidence interval (CI): 0.85, 2.26]; 8 studies). For perioperative pain, auriculotherapy reduced analgesic use (SMD, 0.54 [95% CI: 0.30, 0.77]; 5 studies). For acute pain and chronic pain, auriculotherapy reduced pain intensity (SMD for acute pain, 1.35 [95% CI: 0.08, 2.64], 2 studies; SMD for chronic pain, 1.84 [95% CI: 0.60, 3.07], 5 studies). Removal of poor quality studies did not alter the conclusions. Significant heterogeneity existed among studies of acute and chronic pain, but not perioperative pain.


CONCLUSIONS
Auriculotherapy may be effective for the treatment of a variety of types of pain, especially postoperative pain. However, a more accurate estimate of the effect will require further large, well-designed trials.}, number={10}, journal={JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE}, author={Asher, Gary N. and Jonas, Daniel E. and Coeytaux, Remy R. and Reilly, Aimee C. and Loh, Yen L. and Motsinger-Reif, Alison A. and Winham, Stacey J.}, year={2010}, month={Oct}, pages={1097–1108} }