@article{suyemoto_hamrick_spears_horton_washington_havell_borst_orndorff_2013, title={Extrauterine Listeriosis in the gravid mouse influences embryonic growth and development}, volume={8}, number={8}, journal={PLoS One}, author={Suyemoto, M. M. and Hamrick, T. S. and Spears, P. A. and Horton, J. R. and Washington, I. M. and Havell, E. A. and Borst, L. B. and Orndorff, P. E.}, year={2013} }
 @article{spears_suyemoto_hamrick_wolf_havell_orndorff_2011, title={In Vitro Properties of a Listeria monocytogenes Bacteriophage-Resistant Mutant Predict Its Efficacy as a Live Oral Vaccine Strain}, volume={79}, ISSN={["1098-5522"]}, DOI={10.1128/iai.05700-11}, abstractNote={ABSTRACT A Listeria monocytogenes glcV mutation precludes the binding of certain listerial phages and produces a profound attenuation characterized by the absence of detectable mutants in the livers and spleens of orally inoculated mice. In vitro, we found that the mutant formed plaques on mouse enterocyte monolayers as efficiently as the parent but the plaques formed were smaller. Intracellular growth rate determinations and examination of infected enterocytes by light and fluorescence microscopy established that the mutant was impaired not in intracellular growth rate but in cell-to-cell spreading. Because this property is shared by other immunogenic mutants (e.g., actA mutants), our glcV mutant was tested for vaccine efficacy. Oral immunization with the mutant and subsequent oral challenge (22 days postvaccination) with the parent revealed a ca. 10,000-fold increase in protection afforded by the mutant compared to sham-vaccinated controls. The glcV mutant did not stimulate innate immunity under the dose and route employed for vaccination, and an infectivity index time course experiment revealed pronounced mutant persistence in Peyer's patches. The immunogenicity of the glcV mutant compared to an isogenic actA mutant reference strain was next tested in an experiment with a challenge given 52 days postvaccination. Both mutant strains showed scant vital organ infectivity and high levels of protection similar to those seen using the glcV mutant in the 22-day postvaccination challenge. Our results indicate that oral administration of a profoundly attenuated listerial mutant can safely elicit solid protective immunity.}, number={12}, journal={INFECTION AND IMMUNITY}, author={Spears, Patricia A. and Suyemoto, M. Mitsu and Hamrick, Terri S. and Wolf, Rebecca L. and Havell, Edward A. and Orndorff, Paul E.}, year={2011}, month={Dec}, pages={5001–5009} }
 @article{spears_suyemoto_palermo_horton_hamrick_havell_orndorff_2008, title={A Listeria monocytogenes mutant defective in bacteriophage attachment is attenuated in orally inoculated mice and impaired in enterocyte intracellular growth}, volume={76}, ISSN={["0019-9567"]}, DOI={10.1128/IAI.00283-08}, abstractNote={ABSTRACT}, number={9}, journal={INFECTION AND IMMUNITY}, author={Spears, Patricia A. and Suyemoto, M. Mitsu and Palermo, Angela M. and Horton, John R. and Hamrick, Terri S. and Havell, Edward A. and Orndorff, Paul E.}, year={2008}, month={Sep}, pages={4046–4054} }
 @misc{orndorff_hamrick_smoak_havell_2006, title={Host and bacterial factors in listeriosis pathogenesis}, volume={114}, ISSN={["1873-2542"]}, DOI={10.1016/j.vetmic.2005.12.003}, abstractNote={Members of the Genus Listeria are ubiquitous environmental saprophytic microorganisms. If ingested they can cause a severe disseminated disease (listeriosis) that has a high mortality rate, the highest of any food-borne pathogen, even with antibiotic therapy. Central to the high mortality rate is the hallmark characteristic of the microorganism to grow intracellularly. The presence of listeriae in food processing plants has resulted in many outbreaks of human disease and large scale recalls of processed foods. Despite the ubiquity of the microorganism, the actual disease rate (those animals showing disease signs over those exposed) is quite low and disease is almost always associated with an underlying predisposition (pregnancy being the most common in otherwise normal individuals). There are many features of the pathogenesis of listeriosis that have remained mysterious despite the extensive use of the microorganism in the study of cell-mediated immunity and intracellular growth. Informational advances such as the sequence of the mouse and listerial genomes, and technical advances such as the discovery of listeria-susceptible mouse strains, may renew interest in the study of the natural pathogenesis of the disease. This may be further facilitated by studies that employ the natural inoculation route and mimic common predisposing conditions witnessed in victims of natural outbreaks.}, number={1-2}, journal={VETERINARY MICROBIOLOGY}, author={Orndorff, PE and Hamrick, TS and Smoak, IW and Havell, EA}, year={2006}, month={Apr}, pages={1–15} }
 @article{harris_spears_havell_hamrick_horton_orndorff_2001, title={Characterization of Escherichia coli type 1 pilus mutants with altered binding specificities}, volume={183}, ISSN={["0021-9193"]}, DOI={10.1128/JB.183.13.4099-4102.2001}, abstractNote={ABSTRACT}, number={13}, journal={JOURNAL OF BACTERIOLOGY}, author={Harris, SL and Spears, PA and Havell, EA and Hamrick, TS and Horton, JR and Orndorff, PE}, year={2001}, month={Jul}, pages={4099–4102} }
 @article{hamrick_harris_spears_havell_horton_russell_orndorff_2000, title={Genetic characterization of Escherichia coli type 1 pilus adhesin mutants and identification of a novel binding phenotype}, volume={182}, ISSN={["0021-9193"]}, DOI={10.1128/JB.182.14.4012-4021.2000}, abstractNote={ABSTRACT}, number={14}, journal={JOURNAL OF BACTERIOLOGY}, author={Hamrick, TS and Harris, SL and Spears, PA and Havell, EA and Horton, JR and Russell, PW and Orndorff, PE}, year={2000}, month={Jul}, pages={4012–4021} }
 @article{hamrick_havell_horton_orndorff_2000, title={Host and bacterial factors involved in the innate ability of mouse macrophages to eliminate internalized unopsonized Escherichia coli}, volume={68}, ISSN={["0019-9567"]}, DOI={10.1128/IAI.68.1.125-132.2000}, abstractNote={ABSTRACT}, number={1}, journal={INFECTION AND IMMUNITY}, author={Hamrick, TS and Havell, EA and Horton, JR and Orndorff, PE}, year={2000}, month={Jan}, pages={125–132} }