Michael C. Leopold

Works (5)

Updated: July 5th, 2023 16:02

2002 article

Adsorptive immobilization of cytochrome c on indium/tin oxide (ITO): electrochemical evidence for electron transfer-induced conformational changes

Kasmi, A. E., Leopold, M. C., Galligan, R., Robertson, R. T., Saavedra, S. S., Kacemi, K. E., & Bowden, E. F. (2002, February 1). Electrochemistry Communications, Vol. 4, pp. 177–181.

By: A. Kasmi*, M. Leopold n, R. Galligan n, R. Robertson *, S. Saavedra *, K. Kacemi*, E. Bowden n 

author keywords: cytochrome c monolayers; indium/tin oxide; redox-linked conformational changes; interfacial electron transfer kinetics; unusual quasireversibility
topics (OpenAlex): Electrochemical Analysis and Applications; Electrochemical sensors and biosensors; Molecular Junctions and Nanostructures
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 article

Influence of Gold Substrate Topography on the Voltammetry of Cytochrome c Adsorbed on Carboxylic Acid Terminated Self-Assembled Monolayers

Leopold, M. C., & Bowden, E. F. (2002, February 8). Langmuir, Vol. 18, pp. 2239–2245.

By: M. Leopold n & E. Bowden n 

topics (OpenAlex): Molecular Junctions and Nanostructures; Force Microscopy Techniques and Applications; Electrochemical Analysis and Applications
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2002 article

Influence of Gold Topography on Carboxylic Acid Terminated Self-Assembled Monolayers

Leopold, M. C., Black, J. A., & Bowden, E. F. (2002, January 23). Langmuir, Vol. 18, pp. 978–980.

By: M. Leopold n, J. Black n & E. Bowden n 

topics (OpenAlex): Molecular Junctions and Nanostructures; Polymer Surface Interaction Studies; Analytical Chemistry and Sensors
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 article

3-Hydroxykynurenine and 3-Hydroxyanthranilic Acid Generate Hydrogen Peroxide and Promote α-Crystallin Cross-Linking by Metal Ion Reduction

Goldstein, L. E., Leopold, M. C., Huang, X., Atwood, C. S., Saunders, A. J., Hartshorn, M., … Bush, A. I. (2000, May 26). Biochemistry, Vol. 39, pp. 7266–7275.

By: L. Goldstein  n, M. Leopold n, X. Huang  n, C. Atwood  n, A. Saunders  n, M. Hartshorn n, J. Lim n, K. Faget n ...

MeSH headings : 3-Hydroxyanthranilic Acid / metabolism; Animals; Ascorbic Acid / metabolism; Cataract / etiology; Cattle; Copper / metabolism; Crystallins / metabolism; Electrochemistry; Humans; Hydrogen Peroxide / metabolism; Iron / metabolism; Kynurenine / analogs & derivatives; Kynurenine / metabolism; Lens, Crystalline / metabolism; Metals / metabolism; Oxidation-Reduction; Superoxides / metabolism; Tryptophan / metabolism
topics (OpenAlex): Connexins and lens biology; Tryptophan and brain disorders; Biochemical effects in animals
TL;DR: The reaction of kynurenine pathway catabolites with copper and iron, as well as interactions with the major lenticular structural proteins, the alpha-crystallins, support the possibility that 3HK and 3HAA may be cofactors in the oxidative damage of proteins through interactions with redox-active metals and especially copper. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

1999 article

Cu(II) Potentiation of Alzheimer Aβ Neurotoxicity

Huang, X., Cuajungco, M. P., Atwood, C. S., Hartshorn, M. A., Tyndall, J. D. A., Hanson, G. R., … Bush, A. I. (1999, December 1). Journal of Biological Chemistry, Vol. 274, pp. 37111–37116.

By: X. Huang *, M. Cuajungco *, C. Atwood *, M. Hartshorn*, J. Tyndall *, G. Hanson*, K. Stokes n, M. Leopold n ...

MeSH headings : Amyloid beta-Peptides / toxicity; Animals; Brain / drug effects; Cells, Cultured; Computer Simulation; Copper / metabolism; Copper / pharmacology; Electron Spin Resonance Spectroscopy; Hydrogen Peroxide / metabolism; Oxidation-Reduction; Rats
topics (OpenAlex): Alzheimer's disease research and treatments; Trace Elements in Health; Heavy Metal Exposure and Toxicity
TL;DR: It is reported that Cu(II) markedly potentiates the neurotoxicity exhibited by Aβ in cell culture, suggesting that certain redox active metal ions may be important in exacerbating and perhaps facilitating Aβ-mediated oxidative damage in Alzheimer's disease. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

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