Works (9)

Updated: July 5th, 2023 15:45

2020 journal article

Ursodeoxycholic Acid (UDCA) Mitigates the Host Inflammatory Response during Clostridioides difficile Infection by Altering Gut Bile Acids


By: J. Winston n, A. Rivera n, J. Cai*, R. Thanissery n, S. Montgomery*, A. Patterson*, C. Theriot n

author keywords: C. difficile; FXR; UDCA; bile acids; inflammation; microbiome; ursodiol
MeSH headings : Animals; Bile Acids and Salts / metabolism; Biomarkers; Clostridioides difficile / drug effects; Clostridium Infections / drug therapy; Clostridium Infections / genetics; Clostridium Infections / metabolism; Clostridium Infections / microbiology; Computational Biology / methods; Dose-Response Relationship, Drug; Fibroblast Growth Factors / metabolism; Fragile X Mental Retardation Protein / metabolism; Gastrointestinal Microbiome / drug effects; Gene Expression Profiling; Host-Pathogen Interactions / drug effects; Host-Pathogen Interactions / genetics; Humans; Life Cycle Stages; Mice; Signal Transduction; Transcriptome; Ursodeoxycholic Acid / pharmacology; Ursodeoxycholic Acid / physiology
TL;DR: Although ursodiol pretreatment did not result in a consistent decrease in the C. difficile life cycle in vivo, it was able to attenuate an overly robust inflammatory response that is detrimental to the host during CDI. (via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being (Web of Science; OpenAlex)
Source: Web Of Science
Added: June 15, 2020

2016 journal article

Intermittent At-Home Suctioning of Esophageal Content for Prevention of Recurrent Aspiration Pneumonia in 4 Dogs with Megaesophagus


By: K. Manning n, A. Birkenheuer n, J. Briley n, S. Montgomery n, J. Harris n, S. Vanone n, J. Gookin n

author keywords: Esophagostomy; Regurgitation
MeSH headings : Animals; Catheters, Indwelling; Dog Diseases / etiology; Dog Diseases / prevention & control; Dogs; Enteral Nutrition; Esophageal Achalasia / complications; Esophageal Achalasia / veterinary; Female; Male; Pneumonia, Aspiration / etiology; Pneumonia, Aspiration / prevention & control; Pneumonia, Aspiration / veterinary; Recurrence; Suction / methods; Survival Analysis
TL;DR: Use of intermittent esophageal suctioning in dogs with megaesophagus that continue to regurgitate despite gastrostomy tube feedings can reduce or abolish clinical episodes of aspiration pneumonia. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries, ORCID
Added: August 6, 2018

2016 article

Pathology in Practice

Meichner, K., Montgomery, S. A., Borst, L. B., Murphy, K. M., & Grindem, C. B. (2016, November 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 249, pp. 1023–1026.

By: K. Meichner*, S. Montgomery*, L. Borst*, K. Murphy & C. Grindem*

MeSH headings : Animals; Biopsy; Dog Diseases / pathology; Dog Diseases / therapy; Dogs; Male; Sertoli Cell Tumor / diagnosis; Sertoli Cell Tumor / pathology; Sertoli Cell Tumor / veterinary; Skin Neoplasms / pathology; Skin Neoplasms / veterinary; Testicular Neoplasms / diagnosis; Testicular Neoplasms / pathology; Testicular Neoplasms / veterinary
TL;DR: In collaboration with the American College of Veterinary Pathologists, this work presents a probabilistic procedure to identify the immune checkpoints in the connective tissue of the immune system and results indicate which immune checkpoints are responsible for disease progression. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2014 review

A gnotobiotic mouse model demonstrates that dietary fiber protects against colorectal tumorigenesis in a microbiota- and butyrate-dependent manner

[Review of ]. Cancer Discovery, 4(12), 1387–1397.

By: D. Donohoe, D. Holley, L. Collins, S. Montgomery, A. Whitmore, A. Hillhouse, K. Curry, S. Renner ...

Source: NC State University Libraries
Added: August 6, 2018

2014 article

Pathology in Practice

Stevens, B. J., Montgomery, S. A., Phillips, K. L., Wester, M. W., & Jennings, S. H. (2014, July 1). JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, Vol. 245, pp. 57–59.

By: B. Stevens n, S. Montgomery n, K. Phillips n, M. Wester n & S. Jennings n

MeSH headings : Animals; Dog Diseases / pathology; Dogs; Lung Neoplasms / pathology; Lung Neoplasms / veterinary; Male; Mesothelioma / pathology; Mesothelioma / veterinary; Mesothelioma, Malignant; Peritoneal Neoplasms / pathology; Peritoneal Neoplasms / veterinary
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2014 journal article

Residue 82 of the Chikungunya virus E2 attachment protein modulates viral dissemination and arthritis in mice

Journal of Virology, 89(21), 12180–12192.

By: A. Ashbrook, K. Burrack, L. Silva, S. Montgomery, M. Heise, T. Morrison, T. Dermody

Source: NC State University Libraries
Added: August 6, 2018

2013 journal article

Chronic joint disease caused by persistent Chikungunya virus infection is controlled by the adaptive immune response

Journal of Virology, 87(24), 13878–13888.

By: D. Hawman, K. Stoermer, S. Montgomery, P. Pal, L. Oko, M. Diamond, T. Morrison

Source: NC State University Libraries
Added: August 6, 2018

2012 journal article

Genetic Ablation of Arginase 1 in Macrophages and Neutrophils Enhances Clearance of an Arthritogenic Alphavirus

JOURNAL OF IMMUNOLOGY, 189(8), 4047–4059.

By: K. Stoermer*, A. Burrack*, L. Oko*, S. Montgomery n, L. Borst n, R. Gill*, T. Morrison*

MeSH headings : Alphavirus Infections / enzymology; Alphavirus Infections / immunology; Alphavirus Infections / therapy; Animals; Arginase / antagonists & inhibitors; Arginase / genetics; Cell Line; Chikungunya virus / immunology; Cricetinae; Gene Deletion; Humans; Inflammation / enzymology; Inflammation / immunology; Inflammation / pathology; Macrophages / enzymology; Macrophages / immunology; Macrophages / virology; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Mice, Transgenic; Myeloid Cells / enzymology; Myeloid Cells / immunology; Myeloid Cells / virology; Neutrophils / enzymology; Neutrophils / immunology; Neutrophils / virology; Ross River virus / immunology; Up-Regulation / immunology; Viral Load / immunology
TL;DR: It is found that RRV- and CHIKV-induced musculoskeletal inflammatory lesions, and macrophages present in these lesions, have a unique gene-expression pattern characterized by high expression of arginase 1 and Ym1/Chi3l3 in the absence of FIZZ1/Relmα that is consistent with an M2-like activation phenotype. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2011 journal article

A mouse model of chikungunya virus-induced musculoskeletal inflammatory disease evidence of arthritis, tenosynovitis, myositis, and persistence

American Journal of Pathology, 178(1), 32–40.

By: T. Morrison, L. Oko, S. Montgomery, A. Whitmore, A. Lotstein, B. Gunn, S. Elmore, M. Heise

Source: NC State University Libraries
Added: August 6, 2018

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