@article{garrido_simpson_dahl_bresee_whitehead_lindsey_harris_smith_carter_feldheim_et al._2015, title={Gold nanoparticles to improve HIV drug delivery}, volume={7}, ISSN={["1756-8927"]}, DOI={10.4155/fmc.15.57}, abstractNote={ Background: Antiretroviral therapy (ART) has improved lifespan and quality of life of patients infected with the HIV-1. However, ART has several potential limitations, including the development of drug resistance and suboptimal penetration to selected anatomic compartments. Improving the delivery of antiretroviral molecules could overcome several of the limitations of current ART. Results & Conclusion: Two to ten nanometer diameter inorganic gold crystals serve as a base scaffold to combine molecules with an array of properties in its surface. We show entry into different cell types, antiviral activity of an HIV integrase inhibitor conjugated in a gold nanoparticle and penetration into the brain in vivo without toxicity. Herein, gold nanoparticles prove to be a promising tool to use in HIV therapy. }, number={9}, journal={FUTURE MEDICINAL CHEMISTRY}, author={Garrido, Carolina and Simpson, Carrie A. and Dahl, Noelle P. and Bresee, Jamee and Whitehead, Daniel C. and Lindsey, Erick A. and Harris, Tyler L. and Smith, Candice A. and Carter, Carly J. and Feldheim, Daniel L. and et al.}, year={2015}, pages={1097–1107} } @article{rogers_lindsey_whitehead_mullikin_melander_2011, title={Synthesis and biological evaluation of 2-aminoimidazole/carbamate hybrid anti-biofilm and anti-microbial agents}, volume={21}, ISSN={["1464-3405"]}, DOI={10.1016/j.bmcl.2010.12.057}, abstractNote={The successful marriage of structural features from our 2-aminoimidazole and menthyl carbamate classes of anti-biofilm agents has resulted in the development of a novel hybrid scaffold of biofilm modulators. The compounds were evaluated against a panel of four bacterial strains for anti-biofilm and anti-microbial activity.}, number={4}, journal={BIOORGANIC & MEDICINAL CHEMISTRY LETTERS}, author={Rogers, Steven A. and Lindsey, Erick A. and Whitehead, Daniel C. and Mullikin, Trey and Melander, Christian}, year={2011}, month={Feb}, pages={1257–1260} }