2000 journal article

Effects of TNF-alpha on expression of ICAM-1 in human airway epithelial cells in vitro - Signaling pathways controlling surface and gene expression


By: T. Krunkosky n, B. Fischer n, L. Martin n, N. Jones n, N. Akley n & K. Adler n

MeSH headings : Antibodies, Monoclonal; Bronchi / cytology; Cell Line; Epithelial Cells / enzymology; Epithelial Cells / immunology; Flow Cytometry; Gene Expression / immunology; Humans; In Vitro Techniques; Intercellular Adhesion Molecule-1 / genetics; Intercellular Adhesion Molecule-1 / immunology; L-Lactate Dehydrogenase / metabolism; NF-kappa B / genetics; NF-kappa B / metabolism; Promoter Regions, Genetic / physiology; RNA Processing, Post-Transcriptional / physiology; RNA, Messenger / genetics; RNA, Messenger / metabolism; Respiratory Mucosa / cytology; Signal Transduction / immunology; Tumor Necrosis Factor-alpha / pharmacology
TL;DR: The intracellular signaling pathway leading to enhanced expression appeared to involve activation of a phospholipase C that hydrolyzes phosphatidylcholine (PC-PLC) becaus... (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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