@article{gomez_1999, title={The colostrum-deprived, artificially reared neonatal pig as a model animal for studying rotavirus gastroenteritis}, volume={18}, DOI={10.1080/152279598308038}, abstractNote={Rotavirus gastroenteritis is one of the main causes of acute diarrhea in young humans and animals worldwide. The colostrum-deprived, artificially reared neonatal pig has been extensively used in our laboratory as a model animal for studying an experimentally induced rotaviral gastroenteritis. Details on procurement of newborn pigs, immunologic characteristics, and artificial rearing conditions of colostrum-deprived neonatal pigs as well as on rotavirus inoculation, clinical manifestations, and evaluation of intestinal damage caused by rotavirus infection are described. Our experimentally induced rotavirus gastroenteritis model has been characterized clinically by anorexia, diarrhea, occasional vomiting, and high titers of rotavirus shedding in feces. Data reported here provide additional information, particularly on feeding regimens of pigs before rotavirus inoculation, extent of anorexia, severity of diarrhea, and extent of fecal virus shedding, as well as on the effect of rotavirus infection and size of rotavirus inocula on intestinal damage, growth, and mortality during the postinfection period. On the basis of these results and others previously reported by us and by other researchers, and because of the intestinal anatomy and physiology similarities to that of human infants, the colostrum-deprived, artificially reared neonatal pig is the most suitable and useful model animal for studies designed to evaluate prevention and treatment of rotaviral gastroenteritis.}, number={3}, journal={Pediatric Pathology and Molecular Medicine}, author={Gomez, G. G.}, year={1999}, pages={255–273} }
 @article{gomez_phillips_goforth_1998, title={Effect of immunoglobulin source on survival, growth, and hematological and immunological variables in pigs}, volume={76}, DOI={10.2527/1998.7611}, abstractNote={The effects of feeding different sources of immunoglobulins (sow's colostrum by nursing, SC; no colostrum, NC; bovine colostrum, BC; and porcine immunoglobulins, PI) to neonatal pigs during the first 2 d of life on their subsequent survival, growth, feed intake, feed conversion, incidence of diarrhea, and selected hematological and immunological variables were assessed throughout a 19-d experimental period. After d 2, all pigs were fed the same liquid basal diet. Crossbred neonatal pigs, 10 per treatment, were individually reared after birth (NC, BC, and PI) or 2 d of age (SC) with an automatic feeding device. All pigs of treatments SC and PI, and 80 and 30% (P < .01) of pigs of treatments BC and NC, respectively, survived to the end of the trial. Growth, feed intake, and feed conversion efficiency (gain/feed) of surviving pigs were similar (P > .05), regardless of treatment. A transient physiological scours was observed in 20 to 50% of the pigs between 5 and 7 d of age; by 10 d of age, all pigs had solid feces. Hemoglobin concentration and hematocrit in blood of pigs of treatment NC were lower (P < .05) than those of the other treatments. Concentrations of total serum proteins, trichloroacetic acid-precipitable proteins, and serum IgG of SC pigs were higher (P < .01) than those of pigs in the other treatments. These results showed that porcine immunoglobulins or bovine colostrum can be satisfactorily used as immunoglobulin sources in artificial rearing of colostrum-deprived neonatal pigs.}, number={1}, journal={Journal of Animal Science}, author={Gomez, G. G. and Phillips, O. and Goforth, R. A.}, year={1998}, pages={1–7} }
 @article{gomez_1998, title={The colostrum-deprived, artificially-reared, neonatal pig as a model animal for studying Rotavirus Gastroenteritis}, volume={2}, DOI={10.2741/a206}, abstractNote={Rotavirus gastroenteritis is one of the main causes of acute diarrhea in young humans and animals worldwide. The colostrum-deprived, artificially-reared, neonatal pig has been extensively used in our laboratory as a model animal for studying an experimentally-induced rotaviral gastroenteritis. Details on procurement of newborn pigs, immunological characteristics and artificial rearing conditions of colostrum-deprived neonatal pigs as well as on rotavirus inoculation, clinical manifestations and evaluation of intestinal damage caused by rotavirus infection are described. Our experimentally-induced rotavirus gastroenteritis model has been characterized clinically by anorexia, diarrhea, ocassional vomiting and high titers of rotavirus shedding in feces. Data reported herein provides additional information, particularly on feeding regimens of pigs before rotavirus inoculation, extent of anorexia, severity of diarrhea and extent of fecal virus shedding, as well as on the effect of rotavirus infection and size of rotavirus inocula on intestinal damage, growth and mortality during the post-infection period. On the basis of these results and others previously reported by us and by other researchers, and because of the intestinalanatomy and physiology similarities to that of human infants, the colostrum-deprived, artificially-reared, neonatal pig is the most suitable and useful model animal for studies designed to evaluate prevention and treatment of rotaviral gastroenteritis.}, number={1997 Sept. 15}, journal={Frontiers in Bioscience}, author={Gomez, G. G.}, year={1998}, pages={d471–481} }