Theresa Allio

Works (2)

Updated: July 5th, 2023 16:02

2000 journal article

A comparison of the roles of p53 mutation and AraC inhibition in the enhancement of bleomycin-induced chromatid aberrations in mouse and human cells

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 447(2), 227–237.

By: T. Allio n, E. Donner * & R. Preston*

author keywords: p53; DNA repair; bleomycin; 1-beta-D-arabinofuranosylcytosine; AraC
MeSH headings : Animals; Bleomycin / pharmacology; Cell Line; Cells, Cultured; Chromosome Aberrations / genetics; Cytarabine / pharmacology; DNA Repair / genetics; Dose-Response Relationship, Drug; G2 Phase; Humans; Mice; Mice, Knockout; Mitomycin / pharmacology; Mitotic Index / drug effects; Mutation; Nucleic Acid Synthesis Inhibitors / pharmacology; S Phase; Tumor Suppressor Protein p53 / genetics
TL;DR: The results suggest that an AraC-sensitive DNA repair component is altered or absent in p53-/- cells, and p53 deficiency does not affect DNA replication fidelity or the repair of MMC-induced DNA damage. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Increased sensitivity to chromatid aberration induction by bleomycin and neocarzinostatin results from alterations in a DNA damage response pathway

MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS, 453(1), 5–15.

By: T. Allio n & R. Preston*

author keywords: DNA damage response pathways; ATM; p53; Brca1; Brca2; DNA-PK
MeSH headings : Ataxia Telangiectasia Mutated Proteins; Bleomycin / pharmacology; Cell Cycle Proteins; Cell Line; Chromatids / drug effects; Chromosome Aberrations; DNA Damage; DNA-Binding Proteins; Genes, p53; Humans; Mitosis; Mutagens / pharmacology; Protein Serine-Threonine Kinases / genetics; Tumor Suppressor Proteins; Zinostatin / pharmacology
TL;DR: Differential sensitivities suggest that the ATM phenotype is the result of dual cellular defects, one involving p53 and the other a wortmannin-sensitive component, and the response to BLM- and NCS-induced lesions involves different mechanisms. (via Semantic Scholar)
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

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