Lynn M. Crosby

Works (1)

Updated: July 5th, 2023 16:01

2000 journal article

Origin and distribution of potassium bromate-induced testicular and peritoneal mesotheliomas in rats

TOXICOLOGIC PATHOLOGY, 28(2), 253–266.

By: L. Crosby*, K. Morgan*, B. Gaskill*, D. Wolf* & A. DeAngelo*

author keywords: rat testis; tunics vaginalis; water disinfection byproducts; mesorchium; carcinogenesis; risk assessment
MeSH headings : Animals; Bromates / toxicity; Carcinogenicity Tests; Carcinogens / toxicity; Male; Mesothelioma / chemically induced; Mesothelioma / pathology; Neoplasms, Multiple Primary / chemically induced; Neoplasms, Multiple Primary / pathology; Peritoneal Neoplasms / chemically induced; Peritoneal Neoplasms / pathology; Precancerous Conditions / pathology; Rats; Rats, Inbred F344; Testicular Neoplasms / chemically induced; Testicular Neoplasms / pathology; Testis / blood supply; Testis / pathology
TL;DR: The mesorchium appears to be the major mesothelial target site for potassium bromate-mediated carcinogenesis, and any attempt to determine the role of local dose and tissue susceptibility for the purpose of interspecies risk extrapolation must take into account the complex anatomy and physiology of this region of the visceral and testicular suspensory apparatus. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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