@article{muthusamy_zhang_johnson_yadav_ghashghaei_2017, title={Developmentally defined forebrain circuits regulate appetitive and aversive olfactory learning}, volume={20}, ISSN={["1546-1726"]}, DOI={10.1038/nn.4452}, abstractNote={Postnatal and adult neurogenesis are region- and modality-specific, but the significance of developmentally distinct neuronal populations remains unclear. We demonstrate that chemogenetic inactivation of a subset of forebrain and olfactory neurons generated at birth disrupts responses to an aversive odor. In contrast, novel appetitive odor learning is sensitive to inactivation of adult-born neurons, revealing that developmentally defined sets of neurons may differentially participate in hedonic aspects of sensory learning.}, number={1}, journal={NATURE NEUROSCIENCE}, author={Muthusamy, Nagendran and Zhang, Xuying and Johnson, Caroline A. and Yadav, Prem N. and Ghashghaei, H. Troy}, year={2017}, month={Jan}, pages={20–23} }
 @article{ren_ao_timothy m. o'shea_burda_bernstein_brumm_muthusamy_ghashghaei_carmichael_cheng_et al._2017, title={Ependymal cell contribution to scar formation after spinal cord injury is minimal, local and dependent on direct ependymal injury}, volume={7}, ISSN={["2045-2322"]}, DOI={10.1038/srep41122}, abstractNote={Abstract}, journal={SCIENTIFIC REPORTS}, author={Ren, Yilong and Ao, Yan and Timothy M. O'Shea and Burda, Joshua E. and Bernstein, Alexander M. and Brumm, Andrew J. and Muthusamy, Nagendran and Ghashghaei, H. Troy and Carmichael, S. Thomas and Cheng, Liming and et al.}, year={2017}, month={Jan} }
 @article{sai_morioka_takaesu_muthusamy_ghashghaei_hanafusa_matsumoto_ninomiya-tsuji_2016, title={TAK1 determines susceptibility to endoplasmic reticulum stress and leptin resistance in the hypothalamus}, volume={129}, ISSN={0021-9533 1477-9137}, url={http://dx.doi.org/10.1242/jcs.180505}, DOI={10.1242/jcs.180505}, abstractNote={Sustained endoplasmic reticulum (ER) stress disrupts normal cellular homeostasis and leads to the development of many types of human diseases including metabolic disorders. TAK1 is a member of the mitogen-activated protein kinase kinase kinase (MAP3K) family, and is activated by a diverse set of inflammatory stimuli. Here we demonstrate that TAK1 regulates ER stress and metabolic signaling through modulation of lipid biogenesis. We found that deletion of Tak1 increased ER volume and facilitated ER stress tolerance in cultured cells, which was mediated by upregulation of sterol-regulatory element binding proteins (SREBPs)-dependent lipogenesis. In the in vivo setting, central nervous system (CNS)-specific Tak1 deletion upregulated SREBP target lipogenic genes and blocked ER stress in the hypothalamus. Furthermore, CNS-specific Tak1 deletion prevented ER stress-induced hypothalamic leptin resistance and hyperphagic obesity under high fat diet (HFD). Thus, TAK1 is a critical regulator of ER stress in vivo, which could be a target for alleviation of ER stress and its associated disease conditions.}, number={9}, journal={Journal of Cell Science}, publisher={The Company of Biologists}, author={Sai, Kazuhito and Morioka, Sho and Takaesu, Giichi and Muthusamy, Nagendran and Ghashghaei, H. Troy and Hanafusa, Hiroshi and Matsumoto, Kunihiro and Ninomiya-Tsuji, Jun}, year={2016}, month={Mar}, pages={1855–1865} }
 @misc{muthusamy_chen_yin_mei_bergson_2015, title={Complementary roles of the neuron-enriched endosomal proteins NEEP21 and calcyon in neuronal vesicle trafficking}, volume={132}, number={1}, journal={Journal of Neurochemistry}, author={Muthusamy, N. and Chen, Y. J. and Yin, D. M. and Mei, L. and Bergson, C.}, year={2015}, pages={20–31} }
 @article{muthusamy_sommerville_moeser_stumpo_sannes_adler_blackshear_weimer_ghashghaei_2015, title={MARCKS-dependent mucin clearance and lipid metabolism in ependymal cells are required for maintenance of forebrain homeostasis during aging}, volume={14}, ISSN={["1474-9726"]}, DOI={10.1111/acel.12354}, abstractNote={Summary}, number={5}, journal={AGING CELL}, author={Muthusamy, Nagendran and Sommerville, Laura J. and Moeser, Adam J. and Stumpo, Deborah J. and Sannes, Philip and Adler, Kenneth and Blackshear, Perry J. and Weimer, Jill M. and Ghashghaei, H. Troy}, year={2015}, month={Oct}, pages={764–773} }
 @article{muthusamy_vijayakumar_cheng_ghashghaei_2014, title={A Knock-in Foxj1(CreERT2:: GFP)Mouse for Recombination in Epithelial Cells with Motile Cilia}, volume={52}, ISSN={["1526-968X"]}, DOI={10.1002/dvg.22753}, abstractNote={Summary}, number={4}, journal={GENESIS}, author={Muthusamy, Nagendran and Vijayakumar, Akshitha and Cheng, Gang, Jr. and Ghashghaei, H. Troy}, year={2014}, month={Apr}, pages={350–358} }
 @article{jacquet_muthusamy_sommerville_xiao_liang_zhang_holtzman_ghashghaei_2011, title={Specification of a Foxj1-Dependent Lineage in the Forebrain Is Required for Embryonic-to-Postnatal Transition of Neurogenesis in the Olfactory Bulb}, volume={31}, ISSN={["0270-6474"]}, DOI={10.1523/jneurosci.0171-11.2011}, abstractNote={Establishment of a neural stem cell niche in the postnatal subependymal zone (SEZ) and the rostral migratory stream (RMS) is required for postnatal and adult neurogenesis in the olfactory bulbs (OB). We report the discovery of a cellular lineage in the SEZ-RMS-OB continuum, the specification of which is dependent on the expression of the forkhead transcription factor Foxj1 in mice. Spatially and temporally restricted Foxj1+ neuronal progenitors emerge during embryonic periods, surge during perinatal development, and are active only for the first few postnatal weeks. We show that the development of the unique Foxj1-derived lineage is dependent on Foxj1 expression and is required for overall postnatal neurogenesis in the OB. Strikingly, the production of neurons from Foxj1+ progenitors significantly declines after the early postnatal weeks, but Foxj1-derived neurons in the OB persist during adult periods. For the first time, our study identifies the time- and region-specific activity of a perinatal progenitor domain that is required for transition and progression of OB neurogenesis from the embryonic-to-postnatal periods.}, number={25}, journal={JOURNAL OF NEUROSCIENCE}, author={Jacquet, Benoit V. and Muthusamy, Nagendran and Sommerville, Laura J. and Xiao, Guanxi and Liang, Huixuan and Zhang, Yong and Holtzman, Michael J. and Ghashghaei, H. Troy}, year={2011}, month={Jun}, pages={9368–9382} }