Eric L. R. Seiser

Works (2)

Updated: July 5th, 2023 15:47

2011 journal article

Reading between the lines: molecular characterization of five widely used canine lymphoid tumour cell lines

Veterinary and Comparative Oncology, 11(1), 30–50.

By: E. Seiser n, R. Thomas n, K. Richards  n, M. Kathryn Kelley n, P. Moore *, S. Suter n, M. Breen n 

Contributors: E. Seiser n, R. Thomas n, K. Richards  n, M. Kathryn Kelley n, P. Moore *, S. Suter n, M. Breen n 

author keywords: canine; cell line; comparative; lymphoid neoplasia; microarray; model
MeSH headings : Animals; Cell Line, Tumor; DNA / genetics; DNA / metabolism; Dog Diseases / metabolism; Dogs; Flow Cytometry; Gene Expression Regulation, Neoplastic / physiology; Karyotype; Lymphoma / metabolism; Neoplasm Proteins / genetics; Neoplasm Proteins / metabolism; RNA / genetics; RNA / metabolism; Real-Time Polymerase Chain Reaction / veterinary; Transcriptome
TL;DR: Gene expression profiling and RT-PCR analyses defined the relationship between genomic imbalance and transcriptional dysregulation in each cell line, clarifying their relevance as models of discrete functional pathways with biological and therapeutic significance. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

2011 journal article

Refining tumor-associated aneuploidy through ‘genomic recoding’ of recurrent DNA copy number aberrations in 150 canine non-Hodgkin lymphomas

Leukemia & Lymphoma, 52(7), 1321–1335.

By: R. Thomas n, E. Seiser n, A. Motsinger-Reif*, L. Borst n , V. Valli*, K. Kelley n, S. Suter n, D. Argyle* ...

Contributors: R. Thomas n, E. Seiser n, A. Motsinger-Reif*, L. Borst n , V. Valli*, K. Kelley n, S. Suter n, D. Argyle* ...

author keywords: Comparative genomic hybridization (CGH); canine; lymphoma; chromosome; microarray
MeSH headings : Aneuploidy; Animals; Breeding; Comparative Genomic Hybridization; Cyclin-Dependent Kinase Inhibitor p16 / genetics; DNA Copy Number Variations / genetics; Dogs; Gene Expression Regulation, Neoplastic; Genomics; Immunophenotyping; Lymphoma, Non-Hodgkin / genetics; Lymphoma, Non-Hodgkin / pathology
TL;DR: It is hypothesized that the restricted genetic variation of purebred dogs, combined with the contrasting architecture of the human and canine karyotypes, will increase the penetrance of fundamental NHL-associated chromosomal aberrations in both species. (via Semantic Scholar)
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Sources: Web Of Science, Crossref, NC State University Libraries, ORCID
Added: August 6, 2018

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