@article{monteiro-riviere_linder_inman_saathoff_xia_riviere_2012, title={LACK OF HYDROXYLATED FULLERENE TOXICITY AFTER INTRAVENOUS ADMINISTRATION TO FEMALE SPRAGUE-DAWLEY RATS}, volume={75}, ISSN={["1087-2620"]}, url={http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000303594100001&KeyUID=WOS:000303594100001}, DOI={10.1080/15287394.2012.670894}, abstractNote={Hydroxylated fullerenes (C60OHx) or fullerols are water-soluble carbon nanoparticles that have been explored for potential therapeutic applications. This study assesses acute in vivo tolerance in 8-wk-old female Sprague-Dawley rats to intravenous (iv) administration of 10 mg/kg of well-characterized C60(OH)30. Complete histopathology and clinical chemistries are assessed at 8, 24, and 48 h after dosing. Minor histopathology changes are seen, primarily in one animal. No clinically significant chemistry changes were observed after treatment. These experiments suggest that this fullerol was well tolerated after iv administration to rats.}, number={7}, journal={JOURNAL OF TOXICOLOGY AND ENVIRONMENTAL HEALTH-PART A-CURRENT ISSUES}, author={Monteiro-Riviere, Nancy A. and Linder, Keith E. and Inman, Alfred O. and Saathoff, John G. and Xia, Xin-Rui and Riviere, Jim E.}, year={2012}, pages={367–373} }
 @article{saathoff_inman_xia_riviere_monteiro-riviere_2011, title={In vitro toxicity assessment of three hydroxylated fullerenes in human skin cells}, volume={25}, ISSN={["0887-2333"]}, url={http://gateway.webofknowledge.com/gateway/Gateway.cgi?GWVersion=2&SrcAuth=ORCID&SrcApp=OrcidOrg&DestLinkType=FullRecord&DestApp=WOS_CPL&KeyUT=WOS:000298362500075&KeyUID=WOS:000298362500075}, DOI={10.1016/j.tiv.2011.09.013}, abstractNote={Carbon fullerenes possess unique properties and their interactions with biomolecules have widespread applications. Functionalization of fullerenes with hydroxyl groups (fullerenols) can increase the solubility and potential for cellular interaction, but the health and safety effects of varying degrees of fullerene hydroxylation in biological systems is poorly understood. Existing reports regarding the toxicity and inflammatory potential of fullerenols give conflicting conclusions. To further elucidate the potential for toxicity of fullerenols, human epidermal keratinocytes (HEK) were exposed to fullerenols (low (C60(OH)20), medium (C60(OH)24), and high (C60(OH)32)) at concentrations ranging from 0.000544-42.5 μg/ml for 24 and 48 h. A statistically significant (p<0.05) decrease in viability with alamar Blue (aB) was noted only with C60(OH)32 at 42.5 μg/ml after 24 h. Nanoparticle (NP) controls showed minimal NP/assay interference of the three fullerenols with the aB viability assay. Normalized IL-8 concentration for C60(OH)20 was not significantly different from control, while C60(OH)24 and C60(OH)32 showed a significant decrease at 24 and 48 h. These results suggest that different hydroxylation of fullerenes caused no cytotoxicity or inflammation up to 8.55 μg/ml. These findings suggest that extrapolation across similar NP will be dependent upon surface chemistry and concentration which may affect the degree of agglomeration and thus biological effects.}, number={8}, journal={TOXICOLOGY IN VITRO}, author={Saathoff, J. G. and Inman, A. O. and Xia, X. R. and Riviere, J. E. and Monteiro-Riviere, N. A.}, year={2011}, month={Dec}, pages={2105–2112} }