Works (1)
Updated: July 5th, 2023 16:02
1999 journal article
A physiological model for tert-amyl methyl ether and tert-amyl alcohol: Hypothesis testing of model structures
TOXICOLOGICAL SCIENCES, 49(1), 15–28.
author keywords: physiologically based pharmacokinetic (PBPK) model; tert-amyl methyl ether (TAME); tert-amyl alcohol (TAA)
MeSH headings : Administration, Inhalation; Animals; Glucuronates / metabolism; Liver / metabolism; Male; Models, Biological; Pentanols / toxicity; Protein Binding; Rats; Rats, Inbred F344; Statistics as Topic; Time Factors; Tosylarginine Methyl Ester / metabolism; Tosylarginine Methyl Ester / toxicity
TL;DR:
A physiologically-based pharmacokinetic (PBPK) model was used to describe the disposition of TAME and its major metabolite, tert-amyl alcohol (TAA), in male Fischer-344 rats and indicated that the model incorporating nonspecific binding of TAA provided the best fit to the data.
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