Rebecca L. Semcer

Works (1)

Updated: July 5th, 2023 15:46

2011 journal article

Improving the Catalytic Activity of Hyperthermophilic Pyrococcus horikoshii Prolidase for Detoxification of Organophosphorus Nerve Agents over a Broad Range of Temperatures

Archaea, 2011, 1–9.

By: C. Theriot*, R. Semcer n, S. Shah* & A. Grunden n 

Ed(s): B. C.M. & S. Shah*

MeSH headings : Biotransformation; Chemical Warfare Agents / metabolism; Dipeptidases / genetics; Dipeptidases / metabolism; Enzyme Stability; Hydrogen-Ion Concentration; Mutant Proteins / genetics; Mutant Proteins / metabolism; Mutation; Organophosphates / metabolism; Pyrococcus horikoshii / chemistry; Pyrococcus horikoshii / enzymology; Pyrococcus horikoshii / metabolism; Sarin / metabolism; Soman / metabolism; Temperature
topics (OpenAlex): Peptidase Inhibition and Analysis; Protease and Inhibitor Mechanisms; Neuropeptides and Animal Physiology
TL;DR: Four Ph1prol mutants were isolated which had greater thermostability and improved activity over a broader range of temperatures against Xaa-Pro dipeptides and OP nerve agents compared to wild type Pyrococcus prolidases. (via Semantic Scholar)
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Added: August 6, 2018

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