@article{sri-jayantha_matthews_scharf_2019, title={Scopulariopsis brevicaulis Rhinosinal Infection in a Dog}, volume={55}, ISSN={0587-2871 1547-3317}, url={http://dx.doi.org/10.5326/JAAHA-MS-6869}, DOI={10.5326/JAAHA-MS-6869}, abstractNote={ABSTRACT
               A 1 yr old castrated male American Staffordshire terrier mix was treated for Scopulariopsis brevicaulis that was discovered during an evaluation of chronic rhinosinusitis. A sinusotomy was performed, with intraoperative infusion of amikacin-impregnated gel and systemic administration of postoperative amikacin. Antibiotic therapy was initially chosen because of historic culture of Mycoplasma. Fungal culture of the frontal sinus identified S. brevicaulis by combined phenotypic characterization and DNA sequencing after morphologic analysis failed to identify the organism. Systemic terbinafine therapy was instituted after fungal culture results were available. The patient recovered well and has had no clinical relapse of disease 3 yr after treatment. This is the first reported case of a fungal rhinosinusitis caused by S. brevicaulis in a dog. Reports of Scopulariopsis infections in humans indicate that treatment of S. brevicaulis infection is hampered by multidrug resistance; prognosis may be poor in people with invasive infections and is currently unknown in dogs. Multimodal therapy, including concurrent surgical and systemic intervention, may be necessary to optimize treatment success.}, number={1}, journal={Journal of the American Animal Hospital Association}, publisher={American Animal Hospital Association}, author={Sri-Jayantha, Loren and Matthews, Kyle G. and Scharf, Valery}, year={2019}, month={Jan}, pages={e551–02} }
 @article{blake_trumpatori_mathews_griffith_2017, title={Carotid artery bursting pressure and seal time after multiple uses of a vessel sealing device}, volume={46}, number={4}, journal={Veterinary Surgery}, author={Blake, J. S. and Trumpatori, B. J. and Mathews, K. G. and Griffith, E. H.}, year={2017}, pages={501–506} }
 @article{gookin_correa_peters_malueg_mathews_cullen_seiler_2015, title={Association of Gallbladder Mucocele Histologic Diagnosis with Selected Drug Use in Dogs: A Matched Case-Control Study}, volume={29}, ISSN={["1939-1676"]}, DOI={10.1111/jvim.13649}, abstractNote={BackgroundThe cause of gallbladder mucocele (GBM) formation in dogs currently is unknown. Many available drugs represent a newer generation of xenobiotics that may predispose dogs to GBM formation.ObjectiveTo determine if there is an association between the histologic diagnosis of GBM in dogs and administration of selected drugs.AnimalsEighty‐one dogs with a histologic diagnosis of GBM and 162 breed, age, and admission date‐matched control dogs from a single referral institution.MethodsMedical records of dogs with GBM and control dogs from 2001 to 2011 were reviewed. Owner verification of drug history was sought by a standard questionnaire. Reported use of heartworm, flea, and tick preventatives as well as nonsteroidal anti‐inflammatory drugs, analgesics, corticosteroids, or medications for treatment of osteoarthritis was recorded.ResultsDogs with GBM were 2.2 times as likely to have had reported use of thyroxine (as a proxy for the diagnosis of hypothyroidism) as control dogs (95% confidence interval [CI], 0.949–5.051), 3.6 times as likely to have had reported treatment for Cushing's disease (95% CI, 1.228–10.612), and 2.3 times as likely to have had reported use of products containing imidacloprid (95% CI, 1.094–4.723). Analysis of a data subset containing only Shetland sheepdogs (23 GBM and 46 control) indicated that Shetland sheepdogs with GBM formation were 9.3 times as likely to have had reported use of imidacloprid as were control Shetland sheepdogs (95% CI, 1.103–78.239).Conclusions and Clinical ImportanceThis study provides evidence for an association between selected drug use and GBM formation in dogs. A larger epidemiologic study of Shetland sheepdogs with GBM formation and exposure to imidacloprid is warranted.}, number={6}, journal={JOURNAL OF VETERINARY INTERNAL MEDICINE}, author={Gookin, J. L. and Correa, M. T. and Peters, A. and Malueg, A. and Mathews, K. G. and Cullen, J. and Seiler, G.}, year={2015}, pages={1464–1472} }
 @article{kesimer_cullen_cao_radicioni_mathews_seiler_gookin_2015, title={Excess Secretion of Gel-Forming Mucins and Associated Innate Defense Proteins with Defective Mucin Un-Packaging Underpin Gallbladder Mucocele Formation in Dogs}, volume={10}, ISSN={["1932-6203"]}, DOI={10.1371/journal.pone.0138988}, abstractNote={Mucosal protection of the gallbladder is vital yet we know very little about the mechanisms involved. In domestic dogs, an emergent syndrome referred to as gallbladder mucocele formation is characterized by excessive secretion of abnormal mucus that results in obstruction and rupture of the gallbladder. The cause of gallbladder mucocele formation is unknown. In these first mechanistic studies of this disease, we investigated normal and mucocele-forming dog gallbladders to determine the source, identity, biophysical properties, and protein associates of the culprit mucins with aim to identify causes for abnormal mucus behavior. We established that mucocele formation involves an adoptive excess secretion of gel forming mucins with abnormal properties by the gallbladder epithelium. The mucus is characterized by a disproportionally significant increase in Muc5ac relative to Muc5b, defective mucin un-packaging, and mucin-interacting innate defense proteins that are capable of dramatically altering the physical and functional properties of mucus. These findings provide an explanation for abnormal mucus behavior and based on similarity to mucus observed in the airways of people with cystic fibrosis, suggest that abnormal mechanisms for maintenance of gallbladder epithelial hydration may be an instigating factor for mucocele formation in dogs.}, number={9}, journal={PLOS ONE}, author={Kesimer, Mehmet and Cullen, John and Cao, Rui and Radicioni, Giorgia and Mathews, Kyle G. and Seiler, Gabriela and Gookin, Jody L.}, year={2015}, month={Sep} }
 @article{risselada_mathews_griffith_2015, title={Surgically planned versus histologically measured lateral tumor margins for resection of cutaneous and subcutaneous mast cell tumors in dogs: 46 cases (2010-2013)}, volume={247}, ISSN={["1943-569X"]}, DOI={10.2460/javma.247.2.184}, abstractNote={Abstract
Objective—To compare preplanned lateral surgical margins and measured lateral histologic margins for cutaneous and subcutaneous mast cell tumor (MCT) resections in dogs.
Design—Retrospective case series.
Sample—51 biopsy specimens from dogs (n = 46) with MCTs.
Procedures—All canine patients that underwent curative-intent surgical resection of cutaneous or subcutaneous MCTs from January 1, 2010, through June 30, 2013, with complete medical records including signalment, body condition score (BCS), surgery report (with measured surgical margins), and histopathology report were included. The surgically measured tumor margins in each quadrant were grouped and compared with the corresponding histologic margins. Specimens from dogs with truncal MCTs and a BCS of 7 to 9 on a scale from 1 to 9 (ie, high) were compared with those of dogs with a BCS of 4 to 6 to evaluate effect of BCS on tissue margins.
Results—51 specimens were included. Surgically mapped lateral margins differed significantly from histologically reported margins in all 4 quadrants. The mean histologic margins were 35% to 42% smaller than the surgical margins for the combined 51 specimens. A higher BCS did not significantly influence the magnitude of the decrease in lateral margins measured histologically. No significant difference was found for the magnitude of the differences between any of the 4 lateral margins.
Conclusions and Clinical Relevance—Results of this study suggested that surgical and histologic margins may differ significantly for canine cutaneous and subcutaneous MCTs. This may be a result of tissue shrinkage following excision and fixation, extension of the MCT beyond palpable margins, or both. Histologic measurements may significantly underestimate the tumor-free margins in dogs with cutaneous and subcutaneous MCTs. (J Am Vet Med Assoc 2015;247:184–189)}, number={2}, journal={JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION}, author={Risselada, Marije and Mathews, Kyle G. and Griffith, Emily}, year={2015}, month={Jul}, pages={184–189} }
 @article{trumpatori_carter_hash_davidson_mathews_roe_lascelles_2010, title={Evaluation of a Midhumeral Block of the Radial, Ulnar, Musculocutaneous and Median (RUMM Block) Nerves for Analgesia of the Distal Aspect of the Thoracic Limb in Dogs}, volume={39}, ISSN={0161-3499}, url={http://dx.doi.org/10.1111/j.1532-950x.2010.00712.x}, DOI={10.1111/j.1532-950x.2010.00712.x}, abstractNote={OBJECTIVE
To evaluate a technique for midhumeral peripheral nerve blockade in the dog.


STUDY DESIGN
Cadaveric technique development; in vivo placebo-controlled, prospective crossover study.


ANIMALS
Canine cadavers (n=38) and 8 clinically healthy, adult hound dogs.


METHODS
A technique for peripheral block of the radial, ulnar, musculocutaneous, and median nerves (RUMM block) was evaluated using cadaver limbs. Eight purpose-bred, research dogs were anesthetized; a RUMM block was performed on each thoracic limb. One limb from each dog randomly received 0.5% bupivacaine and the opposite limb was assigned to receive sterile saline solution as a control. After recovery from anesthesia, skin sensation at selected dermatomes was evaluated for 24 hours using a mechanical stimulus. Weight-bearing, conscious proprioception, and withdrawal reflex were also evaluated. One month after initial testing, each dog was reanesthetized and each limb received the opposite treatment.


RESULTS
Sensory thresholds were significantly increased over baseline measurements when compared with control limbs for all nerves. Complete sensory block was achieved in radial (15/16), ulnar (3/16), musculocutaneous (8/16), and median (11/16) nerves, using a mechanical stimulus of analgesia. Complete simultaneous block of all nerves was only obtained in 1 of 16 limbs.


CONCLUSION
RUMM block resulted in desensitization of the skin in the associated dermatomes for 4-10 hours. Complete sensory block of the dermatomes supplied by the radial nerve was most consistent.


CLINICAL RELEVANCE
RUMM block may be an effective technique to provide adjunctive analgesia for dogs undergoing surgery of the distal aspect of the thoracic limb.}, number={7}, journal={Veterinary Surgery}, publisher={Wiley}, author={Trumpatori, Brian J. and Carter, Jennifer E. and Hash, Jon and Davidson, Gigi S. and Mathews, Kyle G. and Roe, Simon C. and Lascelles, B. Duncan X.}, year={2010}, month={Jul}, pages={785–796} }
 @article{mitsui_mathews_linder_kruse_roe_2009, title={Effects of fascial abrasion, fasciotomy, and fascial excision on cutaneous wound healing in cats}, volume={70}, ISSN={0002-9645}, url={http://dx.doi.org/10.2460/ajvr.70.4.532}, DOI={10.2460/ajvr.70.4.532}, abstractNote={Abstract
Objective—To evaluate the effects of fascial abrasion, fasciotomy, and fascial excision on cutaneous wound healing in cats.
Animals—Eight 1- to 3-year-old domestic shorthair cats.
Procedures—8 evenly spaced 4-cm2 skin wounds were created on each cat's dorsum, and the underlying subcutaneous tissue was removed to expose the epaxial muscle fascia. Wounds were randomized to receive 1 of 4 treatments (2 wounds/treatment/cat): fascial abrasion, fasciotomy, fascial excision, or control treatment (muscle fascia not disturbed). Bandages were changed and digital photographs and acetate tracings of the wounds were obtained for planimetry daily for 1 week, every other day for 2 weeks, and then every third day for 3 weeks (ie, 40-day observation period). Digitized images were evaluated for granulation tissue formation, wound contraction (surface area measurements), and area of epithelialization.
Results—The epithelialized area and open and total wound areas did not differ among treatments at any time point. Time to the first appearance of granulation tissue was significantly shorter for all treatment groups, compared with that of the control group. Time to achieve granulation tissue coverage of wound base was significantly shorter following fasciotomy (9.6 days) and fascial excision (9.0 days), compared with that of control treatment (18.5 days) or abrasion (16.7 days). Numbers of wounds that developed exuberant granulation tissue following fascial excision (9/16) and control treatment (3/16) differed significantly.
Conclusions and Clinical Relevance—Fasciotomy and fascial excision facilitated early granulation tissue development in cutaneous wounds in cats. In clinical use, these fascial treatments may expedite secondary wound closure or skin grafting.}, number={4}, journal={American Journal of Veterinary Research}, publisher={American Veterinary Medical Association (AVMA)}, author={Mitsui, Akiko and Mathews, Kyle G. and Linder, Keith E. and Kruse, Meghan A. and Roe, Simon C.}, year={2009}, month={Apr}, pages={532–538} }
 @article{wang_mathews_robertson_stebbins_trumpatori_2005, title={The effects of patient positioning and slice selection on canine acetabular angle assessment with computed tomography}, volume={46}, ISSN={1058-8183 1740-8261}, url={http://dx.doi.org/10.1111/j.1740-8261.2005.00007.x}, DOI={10.1111/j.1740-8261.2005.00007.x}, abstractNote={Acetabular angles (AAs) and dorsal acetabular rim angles acquired by computed tomographic (CT) imaging have been used to assess patient response to juvenile pubic symphysiodesis surgery. The purpose of this study was to evaluate the effects of patient positioning and slice selection on these angles, and an attempt was made to devise a repeatable method of measuring these angles that would eliminate positioning effects. We found significant variation in AAs with small differences in pelvic tilt and slice selection. Dorsal acetabular rim angles were not affected. As a result of positioning differences from one CT study to the next, every attempt should be made to standardize pelvic tilt, or eliminate its effect on AAs by standardizing gantry angle in relation to an anatomic landmark that will not change over time. The floor of the sacral vertebral canal may be a reasonable landmark for this purpose and deserves further study.}, number={1}, journal={Veterinary Radiology <html_ent glyph="@amp;" ascii="&"/> Ultrasound}, publisher={Wiley}, author={Wang, Sandy I. and Mathews, Kyle G. and Robertson, Ian D. and Stebbins, Marty and Trumpatori, Brian J.}, year={2005}, month={Jan}, pages={39–43} }
 @article{mathews_koblik_whitehair_kass_bradley_2001, title={Fragmented palmar metacarpophalangeal sesamoids in dogs: a long-term evaluation}, volume={14}, number={1}, journal={Veterinary and Comparative Orthopaedics and Traumatology}, author={Mathews, K. G. and Koblik, P. D. and Whitehair, J. G. and Kass, P. H. and Bradley, C.}, year={2001}, pages={7–14} }
 @article{mathews_2001, title={Surgery of the canine vagina and vulva}, volume={31}, ISSN={["0195-5616"]}, DOI={10.1016/S0195-5616(01)50205-3}, abstractNote={Accurate diagnosis of canine vaginal abnormalities often requires general anesthesia, vaginoscopy, and contrast radiography. Abdominal ultrasonography, thoracic radiography, computed tomography, and histopathology may also be advised for the workup of mass lesions prior to surgery. Many procedures such as episioplasty and resection of pedunculated vaginal masses or edematous tissue are easily performed with proper planning and equipment (e.g., electrocautery). Consideration should be given to referring more complicated procedures, such as resection of large vaginal masses or vaginal stenoses, to a board certified surgeon. Finally, preoperative placement of a fentanyl patch and preor postoperative epidural analgesia are highly recommended for any vulvo-vaginal surgical procedure.}, number={2}, journal={VETERINARY CLINICS OF NORTH AMERICA-SMALL ANIMAL PRACTICE}, author={Mathews, KG}, year={2001}, month={Mar}, pages={271-+} }
 @article{mathews_gregory_1997, title={Renal transplants in cats: 66 cases (1987-1996)}, volume={211}, number={11}, journal={Journal of the American Veterinary Medical Association}, author={Mathews, K. G. and Gregory, C. R.}, year={1997}, pages={1432–1436} }