Rebecca L. Kitchener

author keywords: vaccine; residual formaldehyde; formaldehyde assay; high-temperature assay

MeSH headings : Automation, Laboratory; Calibration; Carcinogens / analysis; Carcinogens / chemistry; Disinfectants / analysis; Disinfectants / chemistry; Drug Compounding; Drug Contamination / prevention & control; Drug Stability; Fluorescent Dyes / analysis; Fluorescent Dyes / chemistry; Formaldehyde / analysis; Formaldehyde / chemistry; High-Throughput Screening Assays; Hot Temperature; Hydralazine / chemistry; Hydrogen-Ion Concentration; Indicators and Reagents / chemistry; Influenza Vaccines / chemistry; Limit of Detection; Phthalazines / analysis; Phthalazines / chemistry; Quality Control; Reproducibility of Results; Spectrometry, Fluorescence; Triazoles / analysis; Triazoles / chemistry; Volatilization

TL;DR: An assay was developed that is capable of detecting levels of residual formaldehyde in influenza vaccine samples and has attained detection limits of 0.01 µg/mL residualformaldehyde, which is easily able to detect and quantify formaldehyde at levels used in many current vaccine formulations. (via Semantic Scholar)

author keywords: biotechnology; degradation; diagnosis; enzymes; peptides

MeSH headings : Animals; Archaea / enzymology; Bacteria / enzymology; Biodegradation, Environmental; Biotechnology; Collagen / metabolism; Dipeptidases / deficiency; Dipeptidases / metabolism; Dipeptidases / therapeutic use; Enzyme Replacement Therapy; Food Industry; Humans; Proline / metabolism; Protein Structure, Tertiary

TL;DR: The many in vivo functions of procaryotic and eucaryotic prolidases, as well as the most recent advances in therapeutic and biotechnological application of prolidase are discussed. (via Semantic Scholar)