Timothy C. Elston

Works (9)

Updated: July 5th, 2023 16:02

2020 journal article

Mechanistic models of PLC/PKC signaling implicate phosphatidic acid as a key amplifier of chemotactic gradient sensing

PLOS COMPUTATIONAL BIOLOGY, 16(4).

By: J. Nosbisch n, A. Rahman n, K. Mohan n, T. Elston*, J. Bear * & J. Haugh n 

MeSH headings : Animals; Chemotaxis / physiology; Diglycerides / metabolism; Fibroblasts / metabolism; Humans; Intracellular Signaling Peptides and Proteins / metabolism; Membrane Proteins / metabolism; Models, Theoretical; Myristoylated Alanine-Rich C Kinase Substrate / metabolism; Phosphatidic Acids / metabolism; Phosphatidic Acids / physiology; Phospholipase D / metabolism; Phosphorylation; Platelet-Derived Growth Factor / metabolism; Protein Kinase C / metabolism; Protein Kinase C / physiology; Signal Transduction / physiology; Type C Phospholipases / metabolism; Type C Phospholipases / physiology
TL;DR: In simulations of wound invasion, efficient collective migration is achieved with thresholds for chemotaxis matching those of polarization in the reaction-diffusion models, and increasing DAG kinase activity can enhance the robustness of DAG/active PKC polarization with respect to chemoattractant concentration while decreasing their whole-cell levels. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Sources: Web Of Science, NC State University Libraries
Added: May 26, 2020

2003 journal article

Fluctuations in transcription factor binding can explain the graded and binary responses observed in inducible gene expression

JOURNAL OF THEORETICAL BIOLOGY, 226(1), 111–121.

By: . Pirone n & T. Elston*

author keywords: inducible gene expression; stochastic model; binary and graded response
MeSH headings : Animals; Cells / metabolism; DNA-Binding Proteins / metabolism; Gene Expression Regulation; Interleukin-2 / genetics; Models, Biological; NFATC Transcription Factors; Nuclear Proteins; Protein Binding; Signal Transduction / physiology; Transcription Factors / metabolism; Transcription, Genetic; beta-Galactosidase / genetics
TL;DR: The modeling results are in good qualitative agreement with the experimental data, and illustrate how the binary and graded responses can stem from the same underlying mechanism. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2002 journal article

The Brownian ratchet and power stroke models for posttranslational protein translocation into the endoplasmic reticulum

BIOPHYSICAL JOURNAL, 82(3), 1239–1253.

By: T. Elston n

MeSH headings : Algorithms; Binding Sites; Biophysical Phenomena; Biophysics; Dose-Response Relationship, Drug; Endoplasmic Reticulum / metabolism; Least-Squares Analysis; Likelihood Functions; Models, Statistical; Models, Theoretical; Monte Carlo Method; Protein Binding; Protein Transport; Time Factors
TL;DR: It is revealed that translocation involves a single rate-limiting step, which is postulated to be the release of the signal sequence from the translocation channel, and the data considered here cannot be used to reject this import mechanism. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2001 journal article

A linear two-state model with complex dynamics

PHYSICS LETTERS A, 280(4), 204–208.

By: T. Elston n & T. Kepler*

Source: Web Of Science
Added: August 6, 2018

2001 journal article

Stochasticity in transcriptional regulation: Origins, consequences, and mathematical representations

BIOPHYSICAL JOURNAL, 81(6), 3116–3136.

By: T. Kepler n & T. Elston n

MeSH headings : Feedback, Physiological; Gene Expression Regulation; Models, Theoretical; Monte Carlo Method; Promoter Regions, Genetic; Stochastic Processes; Time Factors; Transcription, Genetic
TL;DR: Stochastic bistability where the deterministic equations predict monostability and vice-versa is found; among them, bifurcations driven solely by changing the rate of operator fluctuations even as the underlying deterministic system remains unchanged are found. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

A macroscopic description of biomolecular transport

JOURNAL OF MATHEMATICAL BIOLOGY, 41(3), 189–206.

By: T. Elston n

author keywords: diffusion coefficient; processive enzyme; stochastic process
MeSH headings : Algorithms; Biological Transport, Active; Diffusion; Kinetics; Models, Biological; Monte Carlo Method; Proteins / metabolism
TL;DR: A general algorithm for computing the effective diffusion coefficient of a general class of biomolecular transport processes and takes into account the effects of thermal diffusion and chemical kinetics is presented. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Models of post-translational protein translocation

BIOPHYSICAL JOURNAL, 79(5), 2235–2251.

By: T. Elston n

MeSH headings : Animals; Biological Transport, Active; Biophysical Phenomena; Biophysics; Endoplasmic Reticulum / metabolism; HSP70 Heat-Shock Proteins / chemistry; HSP70 Heat-Shock Proteins / metabolism; Kinetics; Mitochondria / metabolism; Models, Biological; Protein Conformation; Protein Processing, Post-Translational; Proteins / chemistry; Proteins / metabolism
TL;DR: Qualitative differences between the models occur in the behavior of the mean velocity and effective diffusion coefficient as a function of Hsp-70 concentration, and an experimental method is proposed for measuring these two quantities. (via Semantic Scholar)
UN Sustainable Development Goals Color Wheel
UN Sustainable Development Goal Categories
Source: Web Of Science
Added: August 6, 2018

2000 journal article

Protein flexibility and the correlation ratchet

SIAM Journal on Applied Mathematics, 61(3), 842–867.

By: T. Elston & C. Peskin

Source: NC State University Libraries
Added: August 6, 2018

2000 journal article

The role of protein flexibility in molecular motor function: Coupled diffusion in a tilted periodic potential

SIAM JOURNAL ON APPLIED MATHEMATICS, 60(3), 842–867.

By: T. Elston n & C. Peskin *

author keywords: biomolecular motors; Brownian ratchet; protein flexibility; stochastic processes; diffusion equation
TL;DR: This paper evaluates the influence of the elasticity of the tether on the speed of an imperfect Brownian ratchet in two limiting cases: (1) large diffusion coefficient of the motor and (2) large potential barrier against reverse motion at each r... (via Semantic Scholar)
Source: Web Of Science
Added: August 6, 2018

Citation Index includes data from a number of different sources. If you have questions about the sources of data in the Citation Index or need a set of data which is free to re-distribute, please contact us.

Certain data included herein are derived from the Web of Science© and InCites© (2025) of Clarivate Analytics. All rights reserved. You may not copy or re-distribute this material in whole or in part without the prior written consent of Clarivate Analytics.