Works (4)
Updated: July 5th, 2023 21:16
2018 journal article
The prevalent Boxer MHC class Ia allotype dog leukocyte antigen (DLA)-88*034:01 preferentially binds nonamer peptides with a defined motif
HLA, 92(6), 403–407.
author keywords: amino acids; binding motif; dogs; MHC class I; peptides; tandem mass spectrometry
MeSH headings : Amino Acid Motifs; Amino Acids / chemistry; Amino Acids / immunology; Animals; Antigens, Neoplasm / analysis; Antigens, Neoplasm / genetics; Antigens, Neoplasm / immunology; Dogs; Epitopes / chemistry; Epitopes / genetics; Epitopes / immunology; Gene Expression; Histocompatibility Antigens Class I / chemistry; Histocompatibility Antigens Class I / genetics; Histocompatibility Antigens Class I / immunology; Oligopeptides / chemistry; Oligopeptides / genetics; Oligopeptides / immunology; Protein Binding; T-Lymphocytes / chemistry; T-Lymphocytes / immunology; Tandem Mass Spectrometry
TL;DR:
Mass spectrometry of eluted peptides showed a preference for nonamers with conserved amino acid preferences that should expedite finding epitopes restricted by this DLA‐88 allotype, which is popular, inbred dogs with increased risks of relevant target cancers and restricted MHC diversity.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science; OpenAlex)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: January 14, 2019
2013 journal article
Characterization and allelic variation of the transporters associated with antigen processing (TAP) genes in the domestic dog (Canis lupus familiaris)
Developmental & Comparative Immunology, 41(4), 578–586.
author keywords: Alleles; Canine; Immunology; Splice variants; Transporter associated with antigen processing
MeSH headings : ATP-Binding Cassette Transporters / genetics; Alleles; Amino Acid Sequence; Animals; Antigen Presentation / genetics; Cell Line; Dogs; Genetic Variation; Histocompatibility Antigens Class I / genetics; Humans; Mice; Molecular Sequence Data; Phylogeny; Promoter Regions, Genetic; Protein Isoforms; Wolves / genetics
TL;DR:
The promoter and coding regions of the canine TAP1 and TAP2 genes, which encode the homologous subunits forming the TAP heterodimer, are reported, which should prove useful in investigating the association of specific TAP defects or alleles with immunity to intracellular pathogens and cancer in dogs.
(via Semantic Scholar)
europepmc.org (repository)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, Crossref, ORCID, NC State University Libraries
Added: August 6, 2018
2013 journal article
Polymorphisms and tissue expression of the feline leukocyte antigen class I loci FLAI-E, FLAI-H, and FLAI-K
Immunogenetics, 65(9), 675–689.
author keywords: Cat; Major histocompatibility complex; Polymorphism; Classical class I genes
MeSH headings : Amino Acid Sequence; Animals; CD8-Positive T-Lymphocytes / immunology; Cats / genetics; Cats / immunology; Cloning, Molecular; Complementarity Determining Regions / genetics; Genotype; Histocompatibility Antigens Class I / chemistry; Histocompatibility Antigens Class I / genetics; Models, Animal; Molecular Sequence Data; Polymorphism, Single Nucleotide; Sequence Alignment; Viruses / immunology
TL;DR:
Alleles could be assigned to a specific locus with reasonable confidence, although there was evidence of potentially confounding interlocus recombination between FLAI-E andFLAI-K, and hypervariable regions across these genes permitted the assignment of names to both novel and established alleles.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries, Crossref
Added: August 6, 2018
2012 journal article
A cell-based MHC stabilization assay for the detection of peptide binding to the canine classical class I molecule, DLA-88
VETERINARY IMMUNOLOGY AND IMMUNOPATHOLOGY, 150(3-4), 206–212.
author keywords: Canine; CD8(+) T lymphocytes; MHC; Peptides/epitopes
MeSH headings : Animals; Biological Assay / methods; Biological Assay / veterinary; CD8-Positive T-Lymphocytes / metabolism; Cell Line, Tumor; Cell Membrane; Dogs / metabolism; Epitopes; Gene Expression Regulation / physiology; Histocompatibility Antigens Class I / chemistry; Histocompatibility Antigens Class I / metabolism; Mice; Protein Binding; Protein Subunits
TL;DR:
The potential to use RMA-S cells transfected with canine alleles as a tool for CTL epitope discovery in this species is demonstrated, and the high false positive rate with this analysis ideally requires binding confirmation.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, ORCID, NC State University Libraries
Added: August 6, 2018
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