Works (7)
Updated: July 5th, 2023 16:02
2004 journal article
The effect of substitution patterns on the release rates of opioid peptides DADLE and [Leu(5)]-enkephalin from coumarin prodrug moieties
BIOORGANIC CHEMISTRY, 32(2), 109–123.
author keywords: coumarin; cyclic prodrug; opioid peptide; esterase; structural effect
MeSH headings : Coumarins / chemistry; Coumarins / metabolism; Enkephalin, Leucine-2-Alanine / analogs & derivatives; Enkephalin, Leucine-2-Alanine / chemical synthesis; Enkephalin, Leucine-2-Alanine / chemistry; Enkephalin, Leucine-2-Alanine / metabolism; Enkephalins / chemical synthesis; Enkephalins / chemistry; Enkephalins / metabolism; Esterases / metabolism; Kinetics; Molecular Structure; Prodrugs / chemical synthesis; Prodrugs / chemistry; Prodrugs / metabolism
TL;DR:
Aimed at further understanding the structure-release rate relationship of the coumarin-based cyclic prodrugs, a series of substituted coumarinic acid derivatives of opioid peptides, DADLE, and [Leu(5)]-enkephalin are synthesized and examined.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2003 journal article
A neural network model with bounded-weights for pattern classification
Computers & Operations Research, 31(9), 1411–1426.
author keywords: pattern classification; neural networks; multi-layer perceptrons; radial basis function networks; support vector machines
TL;DR:
A new neural network model is proposed based on the concepts of multi-layer perceptrons, radial basis functions, and support vector machines, which does not require that kernel functions satisfy Mercer's condition, and it can be readily extended to multi-class classification.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018
2003 journal article
Relaxed conditions for radial-basis function networks to be universal approximators
NEURAL NETWORKS, 16(7), 1019–1028.
author keywords: universal approximation; radial-basis function networks
MeSH headings : Neural Networks, Computer
TL;DR:
It is shown that RBFs are not required to be integrable for the REF networks to be universal approximators, and can uniformly approximate any continuous function on a compact set provided that the radial basis activation function is continuous almost everywhere, locally essentially bounded, and not a polynomial.
(via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018
2000 journal article
The effect of phenyl substituents on the release rates of esterase-sensitive coumarin-based prodrugs
Chemical & Pharmaceutical Bulletin, 48(8), 1138–1147.
Source: NC State University Libraries
Added: August 6, 2018
1999 journal article
Building fluorescent sensors by template polymerization: The preparation of a fluorescent sensor for L-tryptophan
BIOORGANIC CHEMISTRY, 27(6), 463–476.
TL;DR:
A new way of making polymeric fluorescent sensors using template polymerization or molecular imprinting techniques is studied, which does not require the de novo design of the complementary binding site and does not rely on any specific structural features of the template molecule or prior knowledge of its three-dimensional structure.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Substituted coumarins as esterase-sensitive prodrug moieties with improved release rates
Bioorganic & Medicinal Chemistry Letters, 9(13), 1795–1800.
Source: NC State University Libraries
Added: August 6, 2018
1998 journal article
Enantioselective polymeric transporters for tryptophan, phenylalanine, and histidine prepared using molecular imprinting techniques
BIOORGANIC CHEMISTRY, 26(6), 309–322.
TL;DR:
Polymeric molecular transporters prepared using molecular imprinting techniques with D -tryptophan, D -phenylalanine, and D -histidine as the templates were found to be able to transport the template amino acids across a hydrophobic chloroform layer in a U-tube at rates that were 1.34- to 3.8-fold higher than the transport of their L -enantiomers.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
16. Peace, Justice and Strong Institutions
(OpenAlex)
Source: Web Of Science
Added: August 6, 2018
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