Yuan Liao

Works (7)

Updated: July 5th, 2023 16:02

2004 article

The effect of substitution patterns on the release rates of opioid peptides DADLE and [Leu5]-enkephalin from coumarin prodrug moieties

Zych, L. A., Yang, W., Liao, Y., Griffin, K. R., & Wang, B. (2004, January 16). Bioorganic Chemistry.

By: L. Zych n, W. Yang n, Y. Liao n, K. Griffin n & B. Wang n

author keywords: coumarin; cyclic prodrug; opioid peptide; esterase; structural effect
MeSH headings : Coumarins / chemistry; Coumarins / metabolism; Enkephalin, Leucine-2-Alanine / analogs & derivatives; Enkephalin, Leucine-2-Alanine / chemical synthesis; Enkephalin, Leucine-2-Alanine / chemistry; Enkephalin, Leucine-2-Alanine / metabolism; Enkephalins / chemical synthesis; Enkephalins / chemistry; Enkephalins / metabolism; Esterases / metabolism; Kinetics; Molecular Structure; Prodrugs / chemical synthesis; Prodrugs / chemistry; Prodrugs / metabolism
topics (OpenAlex): Neuropeptides and Animal Physiology; Receptor Mechanisms and Signaling; Chemical Synthesis and Analysis
TL;DR: Aimed at further understanding the structure-release rate relationship of the coumarin-based cyclic prodrugs, a series of substituted coumarinic acid derivatives of opioid peptides, DADLE, and [Leu(5)]-enkephalin are synthesized and examined. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2003 journal article

A neural network model with bounded-weights for pattern classification

Computers & Operations Research, 31(9), 1411–1426.

By: Y. Liao n, S. Fang n  & H. L.W. Nuttle n

author keywords: pattern classification; neural networks; multi-layer perceptrons; radial basis function networks; support vector machines
topics (OpenAlex): Neural Networks and Applications; Face and Expression Recognition; Advanced Algorithms and Applications
TL;DR: A new neural network model is proposed based on the concepts of multi-layer perceptrons, radial basis functions, and support vector machines, which does not require that kernel functions satisfy Mercer's condition, and it can be readily extended to multi-class classification. (via Semantic Scholar)
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Sources: Web Of Science, NC State University Libraries, Crossref
Added: August 6, 2018

2003 article

Relaxed conditions for radial-basis function networks to be universal approximators

Liao, Y., Fang, S.-C., & Nuttle, H. L. W. (2003, February 28). Neural Networks, Vol. 16, pp. 1019–1028.

By: Y. Liao n, S. Fang n  & H. Nuttle n

author keywords: universal approximation; radial-basis function networks
MeSH headings : Neural Networks, Computer
topics (OpenAlex): Neural Networks and Applications; Image and Signal Denoising Methods; Advanced Numerical Analysis Techniques
TL;DR: It is shown that RBFs are not required to be integrable for the REF networks to be universal approximators, and can uniformly approximate any continuous function on a compact set provided that the radial basis activation function is continuous almost everywhere, locally essentially bounded, and not a polynomial. (via Semantic Scholar)
Sources: Web Of Science, NC State University Libraries
Added: August 6, 2018

2000 journal article

The effect of phenyl substituents on the release rates of esterase-sensitive coumarin-based prodrugs

Chemical & Pharmaceutical Bulletin, 48(8), 1138–1147.

By: Y. Liao, S. Hendrata, S. Bae & B. Wang

Source: NC State University Libraries
Added: August 6, 2018

1999 article

Building Fluorescent Sensors by Template Polymerization: The Preparation of a Fluorescent Sensor for l-Tryptophan

Liao, Y., Wang, W., & Wang, B. (1999, December 1). Bioorganic Chemistry.

By: Y. Liao n, W. Wang n & B. Wang n

topics (OpenAlex): Analytical chemistry methods development; Molecular Sensors and Ion Detection; Analytical Chemistry and Chromatography
TL;DR: A new way of making polymeric fluorescent sensors using template polymerization or molecular imprinting techniques is studied, which does not require the de novo design of the complementary binding site and does not rely on any specific structural features of the template molecule or prior knowledge of its three-dimensional structure. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1999 journal article

Substituted coumarins as esterase-sensitive prodrug moieties with improved release rates

Bioorganic & Medicinal Chemistry Letters, 9(13), 1795–1800.

By: Y. Liao & B. Wang

Source: NC State University Libraries
Added: August 6, 2018

1998 article

Enantioselective Polymeric Transporters for Tryptophan, Phenylalanine, and Histidine Prepared Using Molecular Imprinting Techniques

Liao, Y., Wang, W., & Wang, B. (1998, December 1). Bioorganic Chemistry.

By: Y. Liao n, W. Wang n & B. Wang n

topics (OpenAlex): Analytical chemistry methods development; Mass Spectrometry Techniques and Applications; Analytical Chemistry and Chromatography
TL;DR: Polymeric molecular transporters prepared using molecular imprinting techniques with D -tryptophan, D -phenylalanine, and D -histidine as the templates were found to be able to transport the template amino acids across a hydrophobic chloroform layer in a U-tube at rates that were 1.34- to 3.8-fold higher than the transport of their L -enantiomers. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

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