Connie S. Yarian

Works (5)

Updated: July 5th, 2023 16:02

2002 journal article

Accurate translation of the genetic code depends on tRNA modified nucleosides

JOURNAL OF BIOLOGICAL CHEMISTRY, 277(19), 16391–16395.

By: C. Yarian n, H. Townsend n, W. Czestkowski*, E. Sochacka *, A. Malkiewicz*, R. Guenther n, A. Miskiewicz*, P. Agris n

MeSH headings : Adenosine / analogs & derivatives; Adenosine / chemistry; Asparagine / chemistry; Base Pairing; Base Sequence; Codon; Genetic Code; Molecular Sequence Data; Nucleic Acid Conformation; Nucleosides / metabolism; Protein Biosynthesis; Protein Structure, Tertiary; RNA / metabolism; RNA, Messenger / metabolism; RNA, Ribosomal, 16S / metabolism; RNA, Transfer / metabolism; Ribosomes / metabolism; Thiouridine / analogs & derivatives; Thiouridine / chemistry; Uridine / analogs & derivatives; Uridine / chemistry
TL;DR: It is concluded that modified nucleosides evolved to modulate an anticodon domain structure necessary for many tRNA species to accurately translate the genetic code. (via Semantic Scholar)
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Added: August 6, 2018

2002 journal article

Highly conserved modified nucleosides influence Mg2+-dependent tRNA folding

NUCLEIC ACIDS RESEARCH, 30(21), 4751–4760.

By: K. Nobles n, C. Yarian, G. Liu, R. Guenther & P. Agris

MeSH headings : Base Sequence; Electrophoretic Mobility Shift Assay; Hydrogen Bonding; Lead / pharmacology; Magnesium / pharmacology; Models, Molecular; Nucleic Acid Conformation / drug effects; Nucleosides / chemistry; Nucleosides / metabolism; RNA Stability / drug effects; RNA, Fungal / chemistry; RNA, Fungal / genetics; RNA, Fungal / metabolism; RNA, Transfer, Phe / chemistry; RNA, Transfer, Phe / genetics; RNA, Transfer, Phe / metabolism; Ribonuclease T1 / metabolism; Thermodynamics
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Added: August 6, 2018

2000 journal article

Modified constructs of the tRNA T Psi C domain to probe substrate conformational requirements of m(1)A(58) and m(5)U(54) tRNA methyltransferases

NUCLEIC ACIDS RESEARCH, 28(6), 1374–1380.

By: R. Sengupta  n, S. Vainauskas, C. Yarian, E. Sochacka, A. Malkiewicz, R. Guenther, K. Koshlap, P. Agris

MeSH headings : Animals; Escherichia coli / enzymology; Kinetics; Magnetic Resonance Spectroscopy; Methylation; Nucleic Acid Conformation; Nucleosides / chemistry; Nucleosides / genetics; Nucleosides / metabolism; RNA Stability; RNA, Transfer, Phe / chemical synthesis; RNA, Transfer, Phe / chemistry; RNA, Transfer, Phe / genetics; RNA, Transfer, Phe / metabolism; Substrate Specificity; Temperature; Tetrahymena pyriformis / enzymology; Thermodynamics; Yeasts / genetics; tRNA Methyltransferases / metabolism
TL;DR: It is reported that RAMT can recognize and methylate a TSL heptadecamer, and local conformation around U(54) was found to be an important determinant for the activities of both RAMT and RUMT. (via Semantic Scholar)
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2000 journal article

Modified nucleoside dependent Watson-Crick and wobble codon binding by tRNA(UUU)(Lys) species

BIOCHEMISTRY, 39(44), 13390–13395.

By: C. Yarian n, M. Marszalek n, E. Sochacka  n, A. Malkiewicz n, R. Guenther n, A. Miskiewicz n, P. Agris n

MeSH headings : Adenosine / analogs & derivatives; Adenosine / chemistry; Anticodon / chemistry; Binding Sites; Humans; Nucleic Acid Conformation; Protein Binding; Pseudouridine / chemistry; RNA, Ribosomal, 16S / chemistry; RNA, Transfer, Lys / chemistry; Ribosomal Proteins / chemistry; Structure-Activity Relationship; Thermodynamics; Uridine / analogs & derivatives; Uridine / chemistry
TL;DR: The data suggest that tRNA(Lys)(UUU) species require anticodon domain modifications in the loop to impart an ordered structure to the anticodon for ribosomal binding to AAA and require a combination of modified nucleosides to bind AAG. (via Semantic Scholar)
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1999 journal article

Structural and functional roles of the N1-and N3-protons of Psi at tRNA's position 39

NUCLEIC ACIDS RESEARCH, 27(17), 3543–3549.

By: C. Yarian n, M. Basti*, R. Cain n, G. Ansari n, R. Guenther n, E. Sochacka *, G. Czerwinska*, A. Malkiewicz*, P. Agris*

MeSH headings : Anticodon / chemistry; Genes, Fungal / genetics; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Protons; Pseudouridine / chemistry; RNA, Ribosomal, 16S / chemistry; RNA, Transfer, Phe / chemistry; Ribosomes / chemistry; Structure-Activity Relationship; Temperature; Thermodynamics; Uridine / chemistry; Yeasts / genetics
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Source: Web Of Science
Added: August 6, 2018

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