Works (5)
Updated: July 5th, 2023 16:02
2002 journal article
Accurate translation of the genetic code depends on tRNA modified nucleosides
JOURNAL OF BIOLOGICAL CHEMISTRY, 277(19), 16391–16395.
MeSH headings : Adenosine / analogs & derivatives; Adenosine / chemistry; Asparagine / chemistry; Base Pairing; Base Sequence; Codon; Genetic Code; Molecular Sequence Data; Nucleic Acid Conformation; Nucleosides / metabolism; Protein Biosynthesis; Protein Structure, Tertiary; RNA / metabolism; RNA, Messenger / metabolism; RNA, Ribosomal, 16S / metabolism; RNA, Transfer / metabolism; Ribosomes / metabolism; Thiouridine / analogs & derivatives; Thiouridine / chemistry; Uridine / analogs & derivatives; Uridine / chemistry
TL;DR:
It is concluded that modified nucleosides evolved to modulate an anticodon domain structure necessary for many tRNA species to accurately translate the genetic code.
(via Semantic Scholar)
open access via www.jbc.org (publisher PDF)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2002 journal article
Highly conserved modified nucleosides influence Mg2+-dependent tRNA folding
NUCLEIC ACIDS RESEARCH, 30(21), 4751–4760.
MeSH headings : Base Sequence; Electrophoretic Mobility Shift Assay; Hydrogen Bonding; Lead / pharmacology; Magnesium / pharmacology; Models, Molecular; Nucleic Acid Conformation / drug effects; Nucleosides / chemistry; Nucleosides / metabolism; RNA Stability / drug effects; RNA, Fungal / chemistry; RNA, Fungal / genetics; RNA, Fungal / metabolism; RNA, Transfer, Phe / chemistry; RNA, Transfer, Phe / genetics; RNA, Transfer, Phe / metabolism; Ribonuclease T1 / metabolism; Thermodynamics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Modified constructs of the tRNA T Psi C domain to probe substrate conformational requirements of m(1)A(58) and m(5)U(54) tRNA methyltransferases
NUCLEIC ACIDS RESEARCH, 28(6), 1374–1380.
MeSH headings : Animals; Escherichia coli / enzymology; Kinetics; Magnetic Resonance Spectroscopy; Methylation; Nucleic Acid Conformation; Nucleosides / chemistry; Nucleosides / genetics; Nucleosides / metabolism; RNA Stability; RNA, Transfer, Phe / chemical synthesis; RNA, Transfer, Phe / chemistry; RNA, Transfer, Phe / genetics; RNA, Transfer, Phe / metabolism; Substrate Specificity; Temperature; Tetrahymena pyriformis / enzymology; Thermodynamics; Yeasts / genetics; tRNA Methyltransferases / metabolism
TL;DR:
It is reported that RAMT can recognize and methylate a TSL heptadecamer, and local conformation around U(54) was found to be an important determinant for the activities of both RAMT and RUMT.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
2000 journal article
Modified nucleoside dependent Watson-Crick and wobble codon binding by tRNA(UUU)(Lys) species
BIOCHEMISTRY, 39(44), 13390–13395.
MeSH headings : Adenosine / analogs & derivatives; Adenosine / chemistry; Anticodon / chemistry; Binding Sites; Humans; Nucleic Acid Conformation; Protein Binding; Pseudouridine / chemistry; RNA, Ribosomal, 16S / chemistry; RNA, Transfer, Lys / chemistry; Ribosomal Proteins / chemistry; Structure-Activity Relationship; Thermodynamics; Uridine / analogs & derivatives; Uridine / chemistry
TL;DR:
The data suggest that tRNA(Lys)(UUU) species require anticodon domain modifications in the loop to impart an ordered structure to the anticodon for ribosomal binding to AAA and require a combination of modified nucleosides to bind AAG.
(via Semantic Scholar)
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
1999 journal article
Structural and functional roles of the N1-and N3-protons of Psi at tRNA's position 39
NUCLEIC ACIDS RESEARCH, 27(17), 3543–3549.
MeSH headings : Anticodon / chemistry; Genes, Fungal / genetics; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Protons; Pseudouridine / chemistry; RNA, Ribosomal, 16S / chemistry; RNA, Transfer, Phe / chemistry; Ribosomes / chemistry; Structure-Activity Relationship; Temperature; Thermodynamics; Uridine / chemistry; Yeasts / genetics
UN Sustainable Development Goal Categories
3. Good Health and Well-being
(Web of Science)
Source: Web Of Science
Added: August 6, 2018
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