Connie S. Yarian

Works (5)

Updated: July 5th, 2023 16:02

2002 article

Accurate Translation of the Genetic Code Depends on tRNA Modified Nucleosides

Yarian, C., Townsend, H., Czestkowski, W., Sochacka, E., Malkiewicz, A. J., Guenther, R., … Agris, P. F. (2002, May 1). Journal of Biological Chemistry.

By: C. Yarian n, H. Townsend n, W. Czestkowski*, E. Sochacka *, A. Malkiewicz*, R. Guenther n, A. Miskiewicz*, P. Agris n

MeSH headings : Adenosine / analogs & derivatives; Adenosine / chemistry; Asparagine / chemistry; Base Pairing; Base Sequence; Codon; Genetic Code; Molecular Sequence Data; Nucleic Acid Conformation; Nucleosides / metabolism; Protein Biosynthesis; Protein Structure, Tertiary; RNA / metabolism; RNA, Messenger / metabolism; RNA, Ribosomal, 16S / metabolism; RNA, Transfer / metabolism; Ribosomes / metabolism; Thiouridine / analogs & derivatives; Thiouridine / chemistry; Uridine / analogs & derivatives; Uridine / chemistry
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; RNA Research and Splicing
TL;DR: It is concluded that modified nucleosides evolved to modulate an anticodon domain structure necessary for many tRNA species to accurately translate the genetic code. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2002 article

Highly conserved modified nucleosides influence Mg2+-dependent tRNA folding

Nobles, K. N. (2002, October 30). Nucleic Acids Research.

By: K. Nobles n

MeSH headings : Base Sequence; Electrophoretic Mobility Shift Assay; Hydrogen Bonding; Lead / pharmacology; Magnesium / pharmacology; Models, Molecular; Nucleic Acid Conformation / drug effects; Nucleosides / chemistry; Nucleosides / metabolism; RNA Stability / drug effects; RNA, Fungal / chemistry; RNA, Fungal / genetics; RNA, Fungal / metabolism; RNA, Transfer, Phe / chemistry; RNA, Transfer, Phe / genetics; RNA, Transfer, Phe / metabolism; Ribonuclease T1 / metabolism; Thermodynamics
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; RNA Research and Splicing
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Source: Web Of Science
Added: August 6, 2018

2000 article

Modified Nucleoside Dependent Watson−Crick and Wobble Codon Binding by tRNALysUUU Species

Yarian, C., Marszalek, M., Sochacka, E., Malkiewicz, A., Guenther, R., Miskiewicz, A., & Agris, P. F. (2000, October 10). Biochemistry.

By: C. Yarian n, M. Marszalek n, E. Sochacka  n, A. Malkiewicz n, R. Guenther n, A. Miskiewicz n, P. Agris n

MeSH headings : Adenosine / analogs & derivatives; Adenosine / chemistry; Anticodon / chemistry; Binding Sites; Humans; Nucleic Acid Conformation; Protein Binding; Pseudouridine / chemistry; RNA, Ribosomal, 16S / chemistry; RNA, Transfer, Lys / chemistry; Ribosomal Proteins / chemistry; Structure-Activity Relationship; Thermodynamics; Uridine / analogs & derivatives; Uridine / chemistry
topics (OpenAlex): RNA modifications and cancer; RNA and protein synthesis mechanisms; Peptidase Inhibition and Analysis
TL;DR: The data suggest that tRNA(Lys)(UUU) species require anticodon domain modifications in the loop to impart an ordered structure to the anticodon for ribosomal binding to AAA and require a combination of modified nucleosides to bind AAG. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

2000 article

Modified constructs of the tRNA TPsiC domain to probe substrate conformational requirements of m1A58 and m5U54 tRNA methyltransferases

Sengupta, R. (2000, March 15). Nucleic Acids Research.

By: R. Sengupta  n

MeSH headings : Animals; Escherichia coli / enzymology; Kinetics; Magnetic Resonance Spectroscopy; Methylation; Nucleic Acid Conformation; Nucleosides / chemistry; Nucleosides / genetics; Nucleosides / metabolism; RNA Stability; RNA, Transfer, Phe / chemical synthesis; RNA, Transfer, Phe / chemistry; RNA, Transfer, Phe / genetics; RNA, Transfer, Phe / metabolism; Substrate Specificity; Temperature; Tetrahymena pyriformis / enzymology; Thermodynamics; Yeasts / genetics; tRNA Methyltransferases / metabolism
topics (OpenAlex): RNA modifications and cancer; RNA and protein synthesis mechanisms; Genomics and Phylogenetic Studies
TL;DR: It is reported that RAMT can recognize and methylate a TSL heptadecamer, and local conformation around U(54) was found to be an important determinant for the activities of both RAMT and RUMT. (via Semantic Scholar)
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Source: Web Of Science
Added: August 6, 2018

1999 article

Structural and functional roles of the N1- and N3-protons of   at tRNA's position 39

Yarian, C. S., Basti, M. M., Cain, R. J., Ansari, G., Guenther, R. H., Sochacka, E., … Agris, P. F. (1999, September 1). Nucleic Acids Research.

By: C. Yarian n, M. Basti*, R. Cain n, G. Ansari n, R. Guenther n, E. Sochacka *, G. Czerwinska*, A. Malkiewicz*, P. Agris*

MeSH headings : Anticodon / chemistry; Genes, Fungal / genetics; Magnetic Resonance Spectroscopy; Nucleic Acid Conformation; Protons; Pseudouridine / chemistry; RNA, Ribosomal, 16S / chemistry; RNA, Transfer, Phe / chemistry; Ribosomes / chemistry; Structure-Activity Relationship; Temperature; Thermodynamics; Uridine / chemistry; Yeasts / genetics
topics (OpenAlex): RNA and protein synthesis mechanisms; RNA modifications and cancer; Mass Spectrometry Techniques and Applications
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Source: Web Of Science
Added: August 6, 2018

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